{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:15:45Z","timestamp":1778818545086,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["ARIS J3\\u20132525"],"award-info":[{"award-number":["ARIS J3\\u20132525"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["J5-50176"],"award-info":[{"award-number":["J5-50176"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jpain.2026.106247","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:58:16Z","timestamp":1772096296000},"page":"106247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Neurophysiological potentials mediating the influence of social support on pain"],"prefix":"10.1016","volume":"42","author":[{"given":"Marina","family":"Horvat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Verdnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5111-0259","authenticated-orcid":false,"given":"Sa\u0161a","family":"Zorjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satja","family":"Mulej Bratec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2026.106247_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fnhum.2013.00386","article-title":"The social modulation of pain: others as predictive signals of salience - a systematic review","volume":"7","author":"Krah\u00e9","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.jpain.2026.106247_bib2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neubiorev.2018.07.005","article-title":"Investigating the influence of social support on experimental pain and related physiological arousal: a systematic review and meta-analysis","volume":"92","author":"Che","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jpain.2026.106247_bib3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/AJP.0000000000000624","article-title":"A systematic review of the processes underlying the main and the buffering effect of social support on the experience of pain","volume":"34","author":"Che","year":"2018","journal-title":"Clin J Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib4","doi-asserted-by":"crossref","first-page":"11721","DOI":"10.1073\/pnas.1108239108","article-title":"Attachment figures activate a safety signal-related neural region and reduce pain experience","volume":"108","author":"Eisenberger","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jpain.2026.106247_bib5","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1467-9280.2009.02444.x","article-title":"A picture\u2019s worth: partner photographs reduce experimentally induced pain","volume":"20","author":"Master","year":"2009","journal-title":"Psychol Sci"},{"key":"10.1016\/j.jpain.2026.106247_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013309","article-title":"Viewing pictures of a romantic partner reduces experimental pain: involvement of neural reward systems","volume":"5","author":"Younger","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jpain.2026.106247_bib7","doi-asserted-by":"crossref","first-page":"E2528","DOI":"10.1073\/pnas.1703643115","article-title":"Brain-to-brain coupling during handholding is associated with pain reduction","volume":"115","author":"Goldstein","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jpain.2026.106247_bib8","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jpain.2016.06.007","article-title":"Empathy predicts an experimental pain reduction during touch","volume":"17","author":"Goldstein","year":"2016","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib9","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1467-9280.2006.01832.x","article-title":"Lending a hand: social regulation of the neural response to threat","volume":"17","author":"Coan","year":"2006","journal-title":"Psychol Sci"},{"key":"10.1016\/j.jpain.2026.106247_bib10","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/scan\/nsaa048","article-title":"Touch and social support influence interpersonal synchrony and pain","volume":"15","author":"Reddan","year":"2020","journal-title":"Soc Cogn Affect Neurosci"},{"key":"10.1016\/j.jpain.2026.106247_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/psyp.14299","article-title":"Pain perception and physiological responses are modulated by active support from a romantic partner","volume":"60","author":"Mazza","year":"2023","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jpain.2026.106247_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1515\/sjpain-2019-0025","article-title":"Dispositional empathy is associated with experimental pain reduction during provision of social support by romantic partners","volume":"20","author":"Duschek","year":"2019","journal-title":"Scand J Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib13","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1097\/j.pain.0000000000001599","article-title":"Brain mechanisms of social touch-induced analgesia in females","volume":"160","author":"L\u00f3pez-Sol\u00e0","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib14","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hbm.24368","article-title":"Oxytocin enhances the pain-relieving effects of social support in romantic couples","volume":"40","author":"Kreuder","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jpain.2026.106247_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116053","article-title":"The dorsomedial prefrontal cortex as a flexible hub mediating behavioral as well as local and distributed neural effects of social support context on pain: a Theta Burst Stimulation and TMS-EEG study","volume":"201","author":"Che","year":"2019","journal-title":"NeuroImage"},{"key":"10.1016\/j.jpain.2026.106247_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1155\/2014\/195286","article-title":"The influence of communicative relations on facial responses to pain: does it matter who is watching?","volume":"19","author":"Karmann","year":"2014","journal-title":"Pain Res Manag"},{"key":"10.1016\/j.jpain.2026.106247_bib17","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/scan\/nsu156","article-title":"Attachment style moderates partner presence effects on pain: a laser-evoked potentials study","volume":"10","author":"Krah\u00e9","year":"2015","journal-title":"Soc Cogn Affect Neurosci"},{"key":"10.1016\/j.jpain.2026.106247_bib18","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/j.pain.0000000000000840","article-title":"Observer influences on pain: an experimental series examining same-sex and opposite-sex friends, strangers, and romantic partners","volume":"158","author":"Edwards","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.856874","article-title":"The influence of social signals on the self-experience of pain: a neuroimaging review","volume":"13","author":"Sharvit","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.jpain.2026.106247_bib20","first-page":"1121","article-title":"The social buffering of pain by affective touch: a laser-evoked potential study in romantic couples","volume":"13","author":"Mohr","year":"2018","journal-title":"Soc Cogn Affect Neurosci"},{"key":"10.1016\/j.jpain.2026.106247_bib21","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jpain.2017.12.007","article-title":"The social regulation of pain: autonomic and neurophysiological changes associated with perceived threat","volume":"19","author":"Che","year":"2018","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib22","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/hbm.22661","article-title":"Uncertainty during pain anticipation: the adaptive value of preparatory processes","volume":"36","author":"Seidel","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jpain.2026.106247_bib23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ajem.2018.01.008","article-title":"A systematic review of the pain scales in adults: which to use?","volume":"36","author":"Karcioglu","year":"2018","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jpain.2026.106247_bib24","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.pain.2011.07.005","article-title":"Validity of four pain intensity rating scales","volume":"152","author":"FerreiraValente","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","article-title":"Core outcome measures for chronic pain clinical trials: IMMPACT recommendations","volume":"113","author":"Dworkin","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1515\/sjpain-2018-0012","article-title":"The validity of pain intensity measures: what do the NRS, VAS, VRS, and FPS-R measure?","volume":"18","author":"Thong","year":"2018","journal-title":"Scand J Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2026.106247_bib28","unstructured":"Kothe C., Miyakoshi M., Delorme A. clean_rawdata: EEGLAB plugin for EEG artifact cleaning: version 2.7. 2019."},{"key":"10.1016\/j.jpain.2026.106247_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jneumeth.2014.08.002","article-title":"Digital filter design for electrophysiological data \u2013 a practical approach","volume":"250","author":"Widmann","year":"2015","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2026.106247_bib30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1469-8986.2005.00310.x","article-title":"Affective modulation of brain potentials to painful and nonpainful stimuli","volume":"42","author":"Kenntner-Mabiala","year":"2005","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jpain.2026.106247_bib31","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1038\/s41467-018-06875-x","article-title":"Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli","volume":"9","author":"Tiemann","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jpain.2026.106247_bib32","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3390\/brainsci11091192","article-title":"ERP indicators of self-pain and other pain reductions due to Placebo analgesia responding: the moderating role of the fight-flight-freeze system","volume":"11","author":"Vecchio","year":"2021","journal-title":"Brain Sci"},{"key":"10.1016\/j.jpain.2026.106247_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/17588928.2013.797388","article-title":"Self-construal priming modulates pain perception: event-related potential evidence","volume":"5","author":"Wang","year":"2014","journal-title":"Cogn Neurosci"},{"key":"10.1016\/j.jpain.2026.106247_bib34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00004691-200005000-00007","article-title":"Pain-related somatosensory evoked potentials","volume":"17","author":"Kakigi","year":"2000","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.jpain.2026.106247_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0168-0102(02)00198-0","article-title":"Effects of sleep on pain-related somatosensory evoked potentials in humans","volume":"45","author":"Wang","year":"2003","journal-title":"Neurosci Res"},{"key":"10.1016\/j.jpain.2026.106247_bib36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biopsycho.2008.01.007","article-title":"Distinct effects of attention and affect on pain perception and somatosensory evoked potentials","volume":"78","author":"Kenntner-Mabiala","year":"2008","journal-title":"Biol Psychol"},{"key":"10.1016\/j.jpain.2026.106247_bib37","unstructured":"IBM SPSS Statistics for Windows: version 29.0. IBM Corp; 2023."},{"key":"10.1016\/j.jpain.2026.106247_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B Method"},{"key":"10.1016\/j.jpain.2026.106247_bib39","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.neuron.2008.09.006","article-title":"Prefrontal-subcortical pathways mediating successful emotion regulation","volume":"59","author":"Wager","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2026.106247_bib40","unstructured":"MATLAB: version 24.1. Natick, Massachusetts: The MathWorks Inc.; 2024."},{"key":"10.1016\/j.jpain.2026.106247_bib41","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuroimage.2009.05.043","article-title":"Brain mediators of cardiovascular responses to social threat Part I: reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity","volume":"47","author":"Wager","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.jpain.2026.106247_bib42","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/cercor\/bhac090","article-title":"Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience","volume":"33","author":"Wang","year":"2022","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jpain.2026.106247_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/156869","article-title":"FieldTrip: open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data","volume":"2011","author":"Oostenveld","year":"2011","journal-title":"Comput Intell Neurosci"},{"key":"10.1016\/j.jpain.2026.106247_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijpsycho.2022.03.008","article-title":"Event-related potential studies of emotion regulation: a review of recent progress and future directions","volume":"176","author":"MacNamara","year":"2022","journal-title":"Int J Psychophysiol"},{"key":"10.1016\/j.jpain.2026.106247_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/01.j.pain.0000460309.94442.44","article-title":"Differential neurophysiological correlates of bottom-up and top-down modulations of pain","volume":"156","author":"Tiemann","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106247_bib46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbi.2006.01.007","article-title":"Placebo effects in laser-evoked pain potentials","volume":"20","author":"Wager","year":"2006","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpain.2026.106247_bib47","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1751-9004.2011.00400.x","article-title":"Social baseline theory: the role of social proximity in emotion and economy of action","volume":"5","author":"Beckes","year":"2011","journal-title":"Soc Personal Psychol Compass"},{"key":"10.1016\/j.jpain.2026.106247_bib48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.copsyc.2014.12.021","article-title":"Social baseline theory: the social regulation of risk and effort","volume":"1","author":"Coan","year":"2015","journal-title":"Curr Opin Psychol"},{"key":"10.1016\/j.jpain.2026.106247_bib49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3959(02)00007-6","article-title":"Cognitive modulation of pain: how do attention and emotion influence pain processing","volume":"95","author":"Villemure","year":"2002","journal-title":"Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026000659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026000659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:52:18Z","timestamp":1778817138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590026000659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":49,"alternative-id":["S1526590026000659"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106247","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurophysiological potentials mediating the influence of social support on pain","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc","name":"copyright","label":"Copyright"}],"article-number":"106247"}}