{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:24:37Z","timestamp":1787156677282,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC0735"],"award-info":[{"award-number":["2025ZNSFSC0735"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20690"],"award-info":[{"award-number":["U24A20690"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023ZD0504900"],"award-info":[{"award-number":["2023ZD0504900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071320"],"award-info":[{"award-number":["82071320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371322"],"award-info":[{"award-number":["82371322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2024HXBH023"],"award-info":[{"award-number":["2024HXBH023"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2023ZD0504900"],"award-info":[{"award-number":["2023ZD0504900"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506603"],"award-info":[{"award-number":["2023YFC2506603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jpain.2026.106341","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:13:20Z","timestamp":1780445600000},"page":"106341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structural network dysfunction and aberrant SC-FC coupling correlate with central post-stroke pain of thalamic origin"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-5486","authenticated-orcid":false,"given":"Chen","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-687X","authenticated-orcid":false,"given":"Biqiu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9950-9955","authenticated-orcid":false,"given":"Wendan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-4694","authenticated-orcid":false,"given":"William Robert","family":"Kwapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1857-2604","authenticated-orcid":false,"given":"Ruosu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-312X","authenticated-orcid":false,"given":"Tang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-6597","authenticated-orcid":false,"given":"Yuying","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9716-1569","authenticated-orcid":false,"given":"Youjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2140-1535","authenticated-orcid":false,"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-2965","authenticated-orcid":false,"given":"Xiaocheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-0969","authenticated-orcid":false,"given":"Na","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jpain.2026.106341_bib1","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/brain\/aws153","article-title":"Assessing the risk of central post-stroke pain of thalamic origin by lesion mapping","volume":"135","author":"Sprenger","year":"2012","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.jpain.2026.106341_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/jnnp-2011-301936","article-title":"Thalamic sensory strokes with and without pain: differences in lesion patterns in the ventral posterior thalamus","volume":"83","author":"Krause","year":"2012","journal-title":"J Neurol Neurosurg & Psychiatry"},{"issue":"8","key":"10.1016\/j.jpain.2026.106341_bib3","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/j.1532-2149.2012.00123.x","article-title":"Pain following stroke: a prospective study","volume":"16","author":"Hansen","year":"2012","journal-title":"Eur J Pain"},{"issue":"9","key":"10.1016\/j.jpain.2026.106341_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11916-020-00887-3","article-title":"Diagnosis, treatment, and management of dejerine-roussy syndrome: a comprehensive review","volume":"24","author":"Urits","year":"2020","journal-title":"Curr Pain Headache Rep"},{"issue":"7","key":"10.1016\/j.jpain.2026.106341_bib5","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1007\/s12325-020-01388-w","article-title":"Prevalence and Management Challenges in Central Post-Stroke Neuropathic Pain: A Systematic Review and Meta-analysis","volume":"37","author":"Liampas","year":"2020","journal-title":"Adv Ther"},{"issue":"9","key":"10.1016\/j.jpain.2026.106341_bib6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S1474-4422(09)70176-0","article-title":"Central post-stroke pain: clinical characteristics, pathophysiology, and management","volume":"8","author":"Klit","year":"2009","journal-title":"Lancet Neurol"},{"issue":"12","key":"10.1016\/j.jpain.2026.106341_bib7","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1097\/j.pain.0000000000001998","article-title":"Mapping the network underpinnings of central poststroke pain and analgesic neuromodulation","volume":"161","author":"Elias","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106341_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00787","article-title":"Diffusion Tensor Tractography Studies of Central Post-stroke Pain Due to the Spinothalamic Tract Injury: A Mini-Review","volume":"10","author":"Jang","year":"2019","journal-title":"Front Neurol"},{"issue":"5","key":"10.1016\/j.jpain.2026.106341_bib9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nrneurol.2015.58","article-title":"Modulating the pain network--neurostimulation for central poststroke pain","volume":"11","author":"Hosomi","year":"2015","journal-title":"Nat Rev Neurol"},{"issue":"7","key":"10.1016\/j.jpain.2026.106341_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann","year":"2008","journal-title":"PLoS Biol"},{"issue":"9","key":"10.1016\/j.jpain.2026.106341_bib11","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1007\/s00330-019-06068-0","article-title":"Effects of thalamic infarction on the structural and functional connectivity of the ipsilesional primary somatosensory cortex","volume":"29","author":"Chen","year":"2019","journal-title":"Eur Radiol"},{"issue":"9","key":"10.1016\/j.jpain.2026.106341_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106133","article-title":"Functional reorganization of the default mode network across chronic pain conditions","volume":"9","author":"Baliki","year":"2014","journal-title":"PLoS One"},{"issue":"Pt 4","key":"10.1016\/j.jpain.2026.106341_bib13","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/brain\/awl016","article-title":"Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia","volume":"129","author":"Ducreux","year":"2006","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.jpain.2026.106341_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jpain.2004.11.004","article-title":"Functional magnetic resonance imaging and diffusion tensor imaging in a case of central poststroke pain","volume":"6","author":"Seghier","year":"2005","journal-title":"J Pain"},{"issue":"8","key":"10.1016\/j.jpain.2026.106341_bib15","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41593-018-0188-z","article-title":"Fragility and volatility of structural hubs in the human connectome","volume":"21","author":"Gollo","year":"2018","journal-title":"Nat Neurosci"},{"issue":"Pt 8","key":"10.1016\/j.jpain.2026.106341_bib16","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awu132","article-title":"The hubs of the human connectome are generally implicated in the anatomy of brain disorders","volume":"137","author":"Crossley","year":"2014","journal-title":"Brain"},{"issue":"1-2","key":"10.1016\/j.jpain.2026.106341_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jns.2009.03.012","article-title":"Thalamic infarction disrupts spinothalamocortical projection to the mid-cingulate cortex and supplementary motor area","volume":"281","author":"Kishi","year":"2009","journal-title":"J Neurol Sci"},{"issue":"3","key":"10.1016\/j.jpain.2026.106341_bib18","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00062-020-00966-3","article-title":"Alteration of Resting-state Functional Connectivity in the Sensorimotor Network in Patients with Thalamic Infarction","volume":"31","author":"He","year":"2021","journal-title":"Clin Neuroradiol"},{"issue":"4","key":"10.1016\/j.jpain.2026.106341_bib19","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.neuroimage.2008.03.036","article-title":"Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers","volume":"41","author":"Wedeen","year":"2008","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.jpain.2026.106341_bib20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuroimage.2007.05.012","article-title":"Parametric spherical deconvolution: inferring anatomical connectivity using diffusion MR imaging","volume":"37","author":"Kaden","year":"2007","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.jpain.2026.106341_bib21","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1073858414537560","article-title":"Understanding structural-functional relationships in the human brain: a large-scale network perspective","volume":"21","author":"Wang","year":"2015","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jpain.2026.106341_bib22","series-title":"StatPearls [Internet]","article-title":"Lacunar Syndromes.[Updated 2022 Jul 4]","author":"Venkataraman","year":"2022"},{"issue":"1-2","key":"10.1016\/j.jpain.2026.106341_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)","volume":"114","author":"Bouhassira","year":"2005","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.jpain.2026.106341_bib24","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.ejpain.2007.12.013","article-title":"The Short-Form McGill Pain Questionnaire as an outcome measure: test-retest reliability and responsiveness to change","volume":"12","author":"Strand","year":"2008","journal-title":"Eur J Pain"},{"issue":"11","key":"10.1016\/j.jpain.2026.106341_bib25","first-page":"S240","volume":"63","author":"Hawker","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.jpain.2026.106341_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41592-021-01185-5","article-title":"QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data","author":"Cieslak","year":"2021","journal-title":"Nat Methods"},{"issue":"9","key":"10.1016\/j.jpain.2026.106341_bib27","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1109\/TMI.2010.2045126","article-title":"Generalized q-sampling imaging","volume":"29","author":"Yeh","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.jpain.2026.106341_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116189","article-title":"Automated anatomical labelling atlas 3","volume":"206","author":"Rolls","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpain.2026.106341_bib29","first-page":"386","article-title":"GRETNA: a graph theoretical network analysis toolbox for imaging connectomics","volume":"9","author":"Wang","year":"2015","journal-title":"Front Hum Neurosci"},{"issue":"4","key":"10.1016\/j.jpain.2026.106341_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005226","article-title":"Uncovering intrinsic modular organization of spontaneous brain activity in humans","volume":"4","author":"He","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2026.106341_bib31","doi-asserted-by":"crossref","unstructured":"Hearne L.J., Lin H.Y., Sanz-Leon P., et al. ADHD symptoms map onto noise-driven structure-function decoupling between hub and peripheral brain regions. Mol Psychiatry. 12019;doi:10.1038\/s41380-019-0554-6.","DOI":"10.1038\/s41380-019-0554-6"},{"issue":"1","key":"10.1016\/j.jpain.2026.106341_bib32","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1073\/pnas.1912034117","article-title":"Development of structure-function coupling in human brain networks during youth","volume":"117","author":"Baum","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.jpain.2026.106341_bib33","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/j.pain.0000000000002427","article-title":"Dissecting neuropathic from poststroke pain: the white matter within","volume":"163","author":"Delboni Lemos","year":"2022","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.jpain.2026.106341_bib34","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1111\/ene.14794","article-title":"Alterations of brain network topology and structural connectivity-functional connectivity coupling in capsular versus pontine stroke","volume":"28","author":"Chen","year":"2021","journal-title":"Eur J Neurol"},{"issue":"3","key":"10.1016\/j.jpain.2026.106341_bib35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s11481-012-9386-8","article-title":"Central mechanisms of pain revealed through functional and structural MRI","volume":"8","author":"Davis","year":"2013","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.jpain.2026.106341_bib36","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.120.031520","article-title":"Structural Connectivity Remote From Lesions Correlates With Somatosensory Outcome Poststroke","author":"Koh","year":"2021","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.jpain.2026.106341_bib37","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"issue":"10","key":"10.1016\/j.jpain.2026.106341_bib38","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/j.celrep.2019.07.100","article-title":"Structural Disconnections Explain Brain Network Dysfunction after Stroke","volume":"28","author":"Griffis","year":"2019","journal-title":"Cell Rep"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026001598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026001598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:28:47Z","timestamp":1787153327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590026001598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":38,"alternative-id":["S1526590026001598"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106341","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural network dysfunction and aberrant SC-FC coupling correlate with central post-stroke pain of thalamic origin","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106341","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 \u00a9 Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106341"}}