{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:38:07Z","timestamp":1792856287618,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jpain.2026.106367","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:15:14Z","timestamp":1781936114000},"page":"106367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Spontaneously hypertensive rats exhibit reduced facial pain sensitivity with altered electrophysiology and transcriptomics in the trigeminal ganglia"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-3296","authenticated-orcid":false,"given":"Basak","family":"Donertas-Ayaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-0993","authenticated-orcid":false,"given":"Niall P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9617-9249","authenticated-orcid":false,"given":"Airam N.","family":"Vivanco-Estela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-5419","authenticated-orcid":false,"given":"Matthew R.","family":"Sapio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-3355","authenticated-orcid":false,"given":"Bruna Balbino","family":"De Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Malphurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-5302","authenticated-orcid":false,"given":"Qianqian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-3093","authenticated-orcid":false,"given":"John K.","family":"Neubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-4114","authenticated-orcid":false,"given":"Robert M.","family":"Caudle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2026.106367_bib1","first-page":"S113","article-title":"Comparison of sensory and pain threshold in tooth pulp stimulation in normotensive man and essential hypertension","volume":"3","author":"Ghione","year":"1985","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/j.jpain.2026.106367_bib2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0006-8993(80)91055-0","article-title":"Altered pain perception in hypertensive humans","volume":"201","author":"Zamir","year":"1980","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2026.106367_bib3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pain.2008.12.010","article-title":"Maternal family history of hypertension attenuates neonatal pain response","volume":"142","author":"France","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3959(01)00477-8","article-title":"Altered central nervous system processing of noxious stimuli contributes to decreased nociceptive responding in individuals at risk for hypertension","volume":"98","author":"France","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/1469-8986.3810107","article-title":"Assessing supraspinal modulation of pain perception in individuals at risk for hypertension","volume":"38","author":"France","year":"2001","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jpain.2026.106367_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3959(97)00111-5","article-title":"Objective evidence of decreased pain perception in normotensives at risk for hypertension","volume":"73","author":"Page","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0304-3959(96)03184-3","article-title":"Resting systolic blood pressure, parental history of hypertension, and sensitivity to noxious stimuli","volume":"68","author":"Stewart","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0304-3940(93)90773-E","article-title":"Centrally administered neuropeptide Y fails to increase food intake but enhances hypoalgesia in spontaneously hypertensive rats","volume":"149","author":"Pich","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2026.106367_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(81)91189-6","article-title":"Naloxone reversible decrease in pain sensitivity in young and adult spontaneously hypertensive rats","volume":"209","author":"Saavedra","year":"1981","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2026.106367_bib10","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1007\/BF01971804","article-title":"Spontaneously (genetic) hypertensive rats: naloxone-reversible and propranolol-reversible decrease in pain sensitivity","volume":"37","author":"Saavedra","year":"1981","journal-title":"Experientia"},{"key":"10.1016\/j.jpain.2026.106367_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.5.2.185","article-title":"Hypoalgesia in genetically hypertensive rats (SHR) is absent in rats with experimental hypertension","volume":"5","author":"Sitsen","year":"1983","journal-title":"Hypertension"},{"key":"10.1016\/j.jpain.2026.106367_bib12","first-page":"R910","article-title":"Pain sensitivity, thermal capability, and brain monoamine turnover in hypertensive rats","volume":"253","author":"Tsai","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpain.2026.106367_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0006-8993(80)90800-8","article-title":"Pain sensitivity and opioid activity in genetically and experimentally hypertensive rats","volume":"184","author":"Zamir","year":"1980","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2026.106367_bib14","series-title":"Neuroanatomy, spinothalamic tract","author":"Al-Chalabi","year":"2025"},{"key":"10.1016\/j.jpain.2026.106367_bib15","series-title":"Encyclopedia of Pain","first-page":"4084","article-title":"Trigeminothalamic tract projections","author":"Ren","year":"2013"},{"key":"10.1016\/j.jpain.2026.106367_bib16","doi-asserted-by":"crossref","first-page":"R223","DOI":"10.1152\/ajpregu.00390.2018","article-title":"Sex differences and the role of ovarian hormones in site-specific nociception of SHR","volume":"317","author":"Santos","year":"2019","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jpain.2026.106367_bib17","doi-asserted-by":"crossref","DOI":"10.3791\/50336","article-title":"Use of the operant orofacial pain assessment device (OPAD) to measure changes in nociceptive behavior","author":"Anderson","year":"2013","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jpain.2026.106367_bib18","doi-asserted-by":"crossref","DOI":"10.3791\/64221","article-title":"Assessment of nerve injury-induced mechanical hypersensitivity in rats using an orofacial operant pain assay","author":"Donertas-Ayaz","year":"2022","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jpain.2026.106367_bib19","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1152\/jn.1997.77.4.2049","article-title":"Responses of cutaneous A-fiber nociceptors to noxious cold","volume":"77","author":"Simone","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2026.106367_bib20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","article-title":"Methods used to evaluate pain behaviors in rodents","volume":"10","author":"Deuis","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jpain.2026.106367_bib21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/978-3-540-34891-7_29","article-title":"Nociception and TRP channels","author":"Tominaga","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jpain.2026.106367_bib22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pain.2005.05.011","article-title":"Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity","volume":"116","author":"Neubert","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib23","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jpain.2026.106367_bib24","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/papr.12811","article-title":"The acute effect of skin preheating on capsaicin-induced central sensitization in humans","volume":"19","author":"Linde","year":"2019","journal-title":"Pain Pract"},{"key":"10.1016\/j.jpain.2026.106367_bib25","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jpain.2009.10.005","article-title":"Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans","volume":"11","author":"Srbely","year":"2010","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib26","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00213-024-06600-1","article-title":"Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number","volume":"241","author":"D\u2019Aquila","year":"2024","journal-title":"Psychopharmacol (Berl)"},{"key":"10.1016\/j.jpain.2026.106367_bib27","article-title":"Within-session decrement of the emission of licking bursts following reward devaluation in rats licking for sucrose","volume":"12","author":"D\u2019Aquila","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2026.106367_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00213-013-3110-0","article-title":"Dopamine on D2-like receptors \u201creboosts\u201d dopamine D1-like receptor-mediated behavioural activation in rats licking for isotonic NaCl solution","volume":"229","author":"Galistu","year":"2013","journal-title":"Psychopharmacol (Berl)"},{"key":"10.1016\/j.jpain.2026.106367_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/chemse\/bjt038","article-title":"The fine temporal structure of the rat licking pattern: what causes the variability in the interlick intervals and how is it affected by the drinking solution?","volume":"38","author":"Lin","year":"2013","journal-title":"Chem Senses"},{"key":"10.1016\/j.jpain.2026.106367_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00455-006-9027-6","article-title":"Generation of the central masticatory pattern and its modification by sensory feedback","volume":"21","author":"Lund","year":"2006","journal-title":"Dysphagia"},{"key":"10.1016\/j.jpain.2026.106367_bib31","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0149-7634(98)00003-7","article-title":"Licking behavior in the rat: measurement and situational control of licking frequency","volume":"22","author":"Weijnen","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jpain.2026.106367_bib32","article-title":"Effects of oxaliplatin on facial sensitivity to cool temperatures and TRPM8 expressing trigeminal ganglion neurons in mice","volume":"3","author":"Caudle","year":"2022","journal-title":"Front Pain Res (Lausanne)"},{"key":"10.1016\/j.jpain.2026.106367_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0306-4522(02)00409-8","article-title":"Chemical responsiveness and histochemical phenotype of electrophysiologically classified cells of the adult rat dorsal root ganglion","volume":"115","author":"Petruska","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2026.106367_bib34","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1152\/jn.2000.84.5.2365","article-title":"Subclassified acutely dissociated cells of rat DRG","volume":"84","author":"Petruska","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2026.106367_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176753","article-title":"Sex differences in mouse TRPM8 expressing trigeminal ganglion neurons","volume":"12","author":"Caudle","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2026.106367_bib36","doi-asserted-by":"crossref","unstructured":"Galaxy C. The Galaxy platform for accessible, reproducible, and collaborative data analyses: 2024 update. Nucleic Acids Res. 2024;52:W83-W94. doi:10.1093\/nar\/gkae410.","DOI":"10.1093\/nar\/gkae410"},{"key":"10.1016\/j.jpain.2026.106367_bib37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12859-015-0670-5","article-title":"QoRTs: a comprehensive toolset for RNA-Seq QC","volume":"16","author":"Hartley","year":"2015","journal-title":"BMC Bioinforma"},{"key":"10.1016\/j.jpain.2026.106367_bib38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuron.2020.07.026","article-title":"Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury","volume":"108","author":"Ren","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2026.106367_bib39","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1038\/s41467-019-10802-z","article-title":"Accurate estimation of cell-type composition from gene expression data","volume":"10","author":"Tsoucas","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jpain.2026.106367_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj9173","article-title":"Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia","volume":"10","author":"Bhuiyan","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.jpain.2026.106367_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuron.2021.10.030","article-title":"Beyond t test and ANOVA: applications of mixed-effects models in neuroscience","volume":"110","author":"Yu","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2026.106367_bib42","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1001\/archpsyc.61.3.310","article-title":"Move over ANOVA: progress in repeated-measures analysis","volume":"61","author":"Gueorguieva","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jpain.2026.106367_bib43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2202-11-5","article-title":"The problem of pseudoreplication in neuroscientific studies","volume":"11","author":"Lazic","year":"2010","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.jpain.2026.106367_bib44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0891-0618(00)00080-6","article-title":"Distribution of P2X receptor subunits in rat primary afferents","volume":"20","author":"Petruska","year":"2000","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.jpain.2026.106367_bib45","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.2174\/138161209788489122","article-title":"HCN pacemaker channels and pain","volume":"15","author":"Wickenden","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jpain.2026.106367_bib46","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1113\/jphysiol.2008.165738","article-title":"Hyperpolarization-activated currents in cold thermoreceptors","volume":"587","author":"Orio","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.jpain.2026.106367_bib47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3959(94)90197-X","article-title":"Spinal nociceptive transmission in hypertensive rats","volume":"58","author":"Randich","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib48","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1152\/jn.1996.75.6.2629","article-title":"+ currents in sensory neurons","volume":"75","author":"Gold","year":"1996","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2026.106367_bib49","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fnmol.2018.00253","article-title":"channels in DRG neurons","volume":"11","author":"Zemel","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jpain.2026.106367_bib50","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-neuro-060909-153234","article-title":"Sodium channels in pain","volume":"33","author":"Dib-Hajj","year":"2010","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.jpain.2026.106367_bib51","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-cellbio-101011-155833","article-title":"TRP channels and pain","volume":"29","author":"Julius","year":"2013","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jpain.2026.106367_bib52","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.4081\/ejh.2021.3276","article-title":"2D vs 3D morphological analysis of dorsal root ganglia","volume":"65","author":"Carozzi","year":"2021","journal-title":"Eur J Histochem"},{"key":"10.1016\/j.jpain.2026.106367_bib53","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.cell.2011.11.027","article-title":"Functional organization of mechanosensory neurons","volume":"147","author":"Li","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jpain.2026.106367_bib54","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.neuron.2022.03.003","article-title":"Trigeminal ganglia cell atlas and migraine","volume":"110","author":"Yang","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2026.106367_bib55","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0006-8993(82)90562-5","article-title":"Altered pain perception in SHR","volume":"237","author":"Maixner","year":"1982","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2026.106367_bib56","first-page":"1345","article-title":"Pain perception in SHR","volume":"6","author":"Sitsen","year":"1984","journal-title":"Clin Exp Hypertens A"},{"key":"10.1016\/j.jpain.2026.106367_bib57","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.2001.280.2.R345","article-title":"AI. Hypoalgesia in hypertensive rat","volume":"280","author":"Taylor","year":"2001","journal-title":"S Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jpain.2026.106367_bib58","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pharep.2018.12.002","article-title":"inhibition and pain in hypertensive rats","volume":"71","author":"Aykan","year":"2019","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jpain.2026.106367_bib59","first-page":"387","article-title":"Salt-loading hypertension and nociception","volume":"6","author":"Afolabi","year":"2013","journal-title":"J Pain Res"},{"key":"10.1016\/j.jpain.2026.106367_bib60","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0024-3205(95)00043-6","article-title":"Renin-angiotensin system and nociception","volume":"56","author":"Irvine","year":"1995","journal-title":"Life Sci"},{"key":"10.1016\/j.jpain.2026.106367_bib61","first-page":"325","article-title":"Brain catecholamines in hypertensive rats","volume":"38","author":"Fujino","year":"1984","journal-title":"Acta Med Okayama"},{"key":"10.1016\/j.jpain.2026.106367_bib62","first-page":"399","article-title":"Cutaneous microvascular properties in SHR. Comp Biochem Physiol A","volume":"122","author":"Rendell","year":"1999"},{"key":"10.1016\/j.jpain.2026.106367_bib63","first-page":"349","article-title":"Skin blood flow in SHR and WKY rats. Comp Biochem Physiol A Physiol","volume":"106","author":"Rendell","year":"1993"},{"key":"10.1016\/j.jpain.2026.106367_bib64","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/00004872-199605000-00010","article-title":"Chronic hypertension and skin blood flow","volume":"14","author":"Rendell","year":"1996","journal-title":"J Hypertens"},{"key":"10.1016\/j.jpain.2026.106367_bib65","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/brain\/112.5.1317","article-title":"Capsaicin-induced hyperalgesia","volume":"112","author":"Culp","year":"1989","journal-title":"Brain"},{"key":"10.1016\/j.jpain.2026.106367_bib66","article-title":"Menthol and capsaicin effects in operant pain assay","volume":"9","author":"Anderson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2026.106367_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2015.03.022","article-title":"Mechanical allodynia assay in rats","volume":"248","author":"Rohrs","year":"2015","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2026.106367_bib68","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.archoralbio.2018.04.013","article-title":"Capsaicin-mediated orofacial nociception","volume":"92","author":"Rohrs","year":"2018","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jpain.2026.106367_bib69","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/7854_2014_332","article-title":"Operant pain assays","volume":"20","author":"Murphy","year":"2014","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.jpain.2026.106367_bib70","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pbb.2011.12.005","article-title":"Opioid-mediated antinociception","volume":"101","author":"de Freitas","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jpain.2026.106367_bib71","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1590\/S0100-879X1997000800011","article-title":"Sucrose-induced analgesia","volume":"30","author":"Segato","year":"1997","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jpain.2026.106367_bib72","article-title":"Palatability in SHR","volume":"48","author":"Pereira","year":"2023","journal-title":"Chem Senses"},{"key":"10.1016\/j.jpain.2026.106367_bib73","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbr.2012.10.025","article-title":"Sucrose responding in SHR model","volume":"238","author":"Dommett","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpain.2026.106367_bib74","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/HYPERTENSIONAHA.123.22329","article-title":"Blood pressure measurement methods","volume":"81","author":"Harrison","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.jpain.2026.106367_bib75","first-page":"61","article-title":"Blood pressure and pain perception","volume":"88","author":"al\u2019Absi","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106367_bib76","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0167-8760(98)00057-9","article-title":"Hypertension risk and pain sensitivity","volume":"31","author":"D\u2019Antono","year":"1999","journal-title":"Int J Psychophysiol"},{"key":"10.1016\/j.jpain.2026.106367_bib77","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1440-1681.2005.04156.x","article-title":"Gender differences in SHR","volume":"32","author":"Maris","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jpain.2026.106367_bib78","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0301-0511(99)00006-X","article-title":"Hypertension and pain sensitivity","volume":"50","author":"Nyklicek","year":"1999","journal-title":"Biol Psychol"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026001859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026001859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:13:33Z","timestamp":1792854813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590026001859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":78,"alternative-id":["S1526590026001859"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106367","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spontaneously hypertensive rats exhibit reduced facial pain sensitivity with altered electrophysiology and transcriptomics in the trigeminal ganglia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106367","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc","name":"copyright","label":"Copyright"}],"article-number":"106367"}}