{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:40:37Z","timestamp":1777286437024,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":2356,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Manitoba Institute of Child Health"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpsmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pain and Symptom Management"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.jpainsymman.2012.07.009","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T23:53:09Z","timestamp":1348530789000},"page":"265-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Intranasal Fentanyl in the Palliative Care of Newborns and Infants"],"prefix":"10.1016","volume":"46","author":[{"given":"Michael S.","family":"Harlos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Stenekes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey Max","family":"Chochinov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpainsymman.2012.07.009_bib1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.pcl.2004.01.006","article-title":"Palliative care of the infant with lethal anomalies","volume":"51","author":"Leuthner","year":"2004","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/clpt.1990.2","article-title":"Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide","volume":"47","author":"Osborne","year":"1990","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/clpt.1988.159","article-title":"Sublingual absorption of selected opioid analgesics","volume":"44","author":"Weinberg","year":"1988","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0031-6989(82)80107-0","article-title":"Control of chronic pain in very advanced cancer patients with morphine hydrochloride administered by oral, rectal and sublingual route. Clinical report and preliminary results on morphine pharmacokinetics","volume":"14","author":"Pannuti","year":"1982","journal-title":"Pharmacol Res Commun"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/jpm.2006.0150","article-title":"Rational use of sublingual opioids in palliative medicine","volume":"10","author":"Reisfield","year":"2007","journal-title":"J\u00a0Palliat Med"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jppr200333159","article-title":"Pharmacokinetics of nasal fentanyl","volume":"33","author":"Lim","year":"2003","journal-title":"J\u00a0Pharm Pract Res"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/BF02527870","volume":"7","author":"Striebel","year":"1993","journal-title":"Schmerz"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5055\/jom.2010.0001","article-title":"Pharmacokinetics of intranasal fentanyl spray in patients with cancer and breakthrough pain","volume":"6","author":"Kaasa","year":"2010","journal-title":"J\u00a0Opioid Manag"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib9","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1345\/aph.1L168","article-title":"Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery","volume":"42","author":"Foster","year":"2008","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1742-6723.2010.01257.x","article-title":"Does the standard intravenous solution of fentanyl (50 microg\/mL) administered intranasally have analgesic efficacy?","volume":"22","author":"Crellin","year":"2010","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib11","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/emj.2008.070474","article-title":"Intranasal fentanyl for analgesia in the paediatric emergency department","volume":"27","author":"Finn","year":"2010","journal-title":"Emerg Med J"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib12","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s00247-009-1521-1","article-title":"Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography","volume":"40","author":"Chung","year":"2010","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib13","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF02530425","volume":"7","author":"Striebel","year":"1993","journal-title":"Schmerz"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0885-3924(00)00180-9","article-title":"An assessment of the safety, efficacy, and acceptability of intranasal fentanyl citrate in the management of cancer-related breakthrough pain: a pilot study","volume":"20","author":"Zeppetella","year":"2000","journal-title":"J\u00a0Pain Symptom Manage"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib15","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.jpainsymman.2008.08.002","article-title":"Intranasal fentanyl for episodic breathlessness","volume":"36","author":"Sitte","year":"2008","journal-title":"J\u00a0Pain Symptom Manage"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.clinthera.2008.03.001","article-title":"Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study","volume":"30","author":"Christrup","year":"2008","journal-title":"Clin Ther"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.burns.2003.10.017","article-title":"A\u00a0randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns","volume":"30","author":"Finn","year":"2004","journal-title":"Burns"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/emj.2009.078717","article-title":"Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service","volume":"28","author":"Johnston","year":"2011","journal-title":"Emerg Med J"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib19","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.clinthera.2009.05.022","volume":"31","author":"Kress","year":"2009","journal-title":"Clin Ther"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib20","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1185\/03007990903336135","article-title":"A\u00a0comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial","volume":"25","author":"Mercadante","year":"2009","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib21","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1359-6349(09)70871-7","article-title":"Efficacy and patient preference for intranasal fentanyl spray (INFS) versus oral transmucosal fentanyl citrate (OTFC) for breakthrough cancer pain\u2014an open-label crossover trial. [Abstract]","volume":"7","author":"Mercadante","year":"2009","journal-title":"Eur J Cancer Suppl"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib22","first-page":"S198","article-title":"Ease of use and preference for intranasal fentanyl spray (INFS) versus oral transmucosal fentanyl citrate (OTFC) for breakthrough cancer pain. [Abstract]","volume":"13","author":"Mercadante","year":"2009","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib23","first-page":"S198","article-title":"685 Efficacy of intranasal fentanyl spray (INFS) versus oral transmucosal fentanyl citrate (OTFC) for breakthrough cancer pain: open-label crossover trial. [Abstract]","volume":"13","author":"Mercadante","year":"2009","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib24","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ajem.2007.02.027","article-title":"A\u00a0randomized controlled trial of intranasal fentanyl vs. intravenous morphine for analgesia in the prehospital setting","volume":"25","author":"Rickard","year":"2007","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s001010050257","volume":"45","author":"Schwagmeier","year":"1996","journal-title":"Anaesthesist"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1365-2044.1993.tb07583.x","article-title":"Intranasal fentanyl titration for postoperative pain management in an unselected population","volume":"48","author":"Striebel","year":"1993","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00000542-199208000-00010","article-title":"Postoperative pain management by intranasal demand-adapted fentanyl titration","volume":"77","author":"Striebel","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0952-8180(95)00167-0","article-title":"Patient-controlled intranasal analgesia (PCINA) for the management of postoperative pain: a pilot study","volume":"8","author":"Striebel","year":"1996","journal-title":"J\u00a0Clin Anesth"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF03020941","article-title":"Patient-controlled intranasal analgesia: effective alternative to intravenous PCA for postoperative pain relief","volume":"47","author":"Toussaint","year":"2000","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib30","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1185\/03007991003694340","article-title":"Efficacy of intranasal fentanyl spray versus other opioids for breakthrough pain in cancer","volume":"26","author":"Vissers","year":"2010","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1742-6723.2009.01216.x","article-title":"Intranasal fentanyl in 1-3-year-olds: a prospective study of the effectiveness of intranasal fentanyl as acute analgesia","volume":"21","author":"Cole","year":"2009","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib32","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1542\/peds.2010-0616","article-title":"Intranasal medication delivery for children: a brief review and update","volume":"126","author":"Wolfe","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3109\/10903127.2010.541980","article-title":"Effectiveness of prehospital morphine, fentanyl, and methoxyflurane in pediatric patients","volume":"15","author":"Bendall","year":"2011","journal-title":"Prehosp Emerg Care"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.annemergmed.2006.06.016","article-title":"A\u00a0randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department","volume":"49","author":"Borland","year":"2007","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1442-2026.2002.00344.x","article-title":"Intranasal fentanyl reduces acute pain in children in the emergency department: a safety and efficacy study","volume":"14","author":"Borland","year":"2002","journal-title":"Emerg Med (Fremantle)"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1742-6723.2008.01138.x","article-title":"Comparative review of the clinical use of intranasal fentanyl versus morphine in a paediatric emergency department","volume":"20","author":"Borland","year":"2008","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib37","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1553-2712.2009.00636.x","article-title":"The implementation of intranasal fentanyl for children in a mixed adult and pediatric emergency department reduces time to analgesic administration","volume":"17","author":"Holdgate","year":"2010","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib38","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1553-2712.2010.00905.x","article-title":"Use of intranasal fentanyl for the relief of pediatric orthopedic trauma pain","volume":"17","author":"Saunders","year":"2010","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib39","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1097\/00000542-200012000-00006","article-title":"Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia","volume":"93","author":"Galinkin","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF03020494","article-title":"Intranasal fentanyl provides adequate postoperative analgesia in pediatric patients","volume":"49","author":"Manjushree","year":"2002","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib41","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/j.1460-9592.2008.02789.x","article-title":"Postoperative pain relief in infants undergoing myringotomy and tube placement: comparison of a novel regional anesthetic block to intranasal fentanyl\u2014a pilot analysis","volume":"18","author":"Voronov","year":"2008","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib42","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.burns.2005.05.001","article-title":"Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study","volume":"31","author":"Borland","year":"2005","journal-title":"Burns"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib43","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.pedhc.2010.04.011","article-title":"Intranasal fentanyl for pain management in children: a systematic review of the literature","volume":"25","author":"Mudd","year":"2011","journal-title":"J\u00a0Pediatr Health Care"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/archpedi.155.2.173","article-title":"Consensus statement for the prevention and management of pain in the newborn","volume":"155","author":"Anand","year":"2001","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib45","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.annemergmed.2006.11.031","article-title":"Intranasal fentanyl for acute pain: techniques to enhance efficacy","volume":"49","author":"Wolfe","year":"2007","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jpainsymman.2012.07.009_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1542\/peds.100.1.143","article-title":"Alternative routes of drug administration\u2014advantages and disadvantages (subject review). American Academy of Pediatrics. Committee on Drugs","volume":"100","year":"1997","journal-title":"Pediatrics"}],"container-title":["Journal of Pain and Symptom Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0885392412003740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0885392412003740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:11:01Z","timestamp":1760130661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0885392412003740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0885392412003740"],"URL":"https:\/\/doi.org\/10.1016\/j.jpainsymman.2012.07.009","relation":{},"ISSN":["0885-3924"],"issn-type":[{"value":"0885-3924","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal Fentanyl in the Palliative Care of Newborns and Infants","name":"articletitle","label":"Article Title"},{"value":"Journal of Pain and Symptom Management","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpainsymman.2012.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}