{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:31:16Z","timestamp":1783488676148,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":1096,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005565","name":"Janssen Biotech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpsmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pain and Symptom Management"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jpainsymman.2017.09.017","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T14:00:39Z","timestamp":1506002439000},"page":"307-317.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of Androgen Deprivation Therapy on Pain Perception, Quality of Life, and Depression in Men With Prostate Cancer"],"prefix":"10.1016","volume":"55","author":[{"given":"Thiago","family":"Gagliano-Juc\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Travison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Kantoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Ellen","family":"Taplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Kibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Manley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Hally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richelle","family":"Bearup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusnie M.","family":"Beleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehzad","family":"Basaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpainsymman.2017.09.017_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0304-3959(95)00214-6","article-title":"Gender variations in clinical pain experience","volume":"65","author":"Unruh","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0304-3959(86)90224-1","article-title":"Pain and \u2018hassles\u2019 in the United States: findings of the Nuprin pain report","volume":"27","author":"Sternbach","year":"1986","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1196\/annals.1286.022","article-title":"Gonadectomy affects hormonal and behavioral responses to repetitive nociceptive stimulation in male rats","volume":"1007","author":"Aloisi","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroscience.2016.05.007","article-title":"Insights into the mechanisms and the emergence of sex-differences in pain","volume":"338","author":"Melchior","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1155\/2015\/490610","article-title":"Associations between gender, coping patterns and functioning for individuals with chronic pain: a systematic review","volume":"20","author":"El-Shormilisy","year":"2015","journal-title":"Pain Res Manag"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1526-4637.2008.00558.x","article-title":"Sex-based differences in pain perception and treatment","volume":"10","author":"Paller","year":"2009","journal-title":"Pain Med"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0304-3959(99)00128-1","article-title":"The relationship of sex and clinical pain to experimental pain responses","volume":"83","author":"Fillingim","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib8","doi-asserted-by":"crossref","first-page":"R241","DOI":"10.1152\/ajpregu.00287.2006","article-title":"Sex and gender differences in pain and inflammation: a rapidly maturing field","volume":"291","author":"Berkley","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib9","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.pain.2011.11.025","article-title":"A\u00a0systematic literature review of 10 years of research on sex\/gender and experimental pain perception - part 1: are there really differences between women and men?","volume":"153","author":"Racine","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib10","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1523\/JNEUROSCI.22-12-05100.2002","article-title":"mu-opioid receptor-mediated antinociceptive responses differ in men and women","volume":"22","author":"Zubieta","year":"2002","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.pain.2012.11.016","article-title":"Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosterone","volume":"154","author":"Vincent","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/01.j.pain.0000460308.86819.aa","article-title":"Effects of testosterone replacement in men with opioid-induced androgen deficiency: a randomized controlled trial","volume":"156","author":"Basaria","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib13","doi-asserted-by":"crossref","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017;67:7-30.","DOI":"10.3322\/caac.21387"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.eururo.2016.10.008","article-title":"Global Burden of Urologic cancers, 1990-2013","volume":"71","author":"Dy","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib15","first-page":"232","article-title":"Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate","volume":"22","author":"Huggins","year":"1972","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1012348","article-title":"Radiotherapy and short-term androgen deprivation for localized prostate cancer","volume":"365","author":"Jones","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(02)09408-4","article-title":"Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial","volume":"360","author":"Bolla","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib18","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1200\/JCO.1999.17.11.3461","article-title":"Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group","volume":"17","author":"Bubley","year":"1999","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0302-2838(03)00208-2","article-title":"The impact of androgen deprivation therapy on health related quality of life in asymptomatic men with lymph node positive prostate cancer","volume":"44","author":"van Andel","year":"2003","journal-title":"Eur Urol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib20","first-page":"534","article-title":"Androgen deprivation therapy, insulin resistance, and cardiovascular mortality: an inconvenient truth","volume":"29","author":"Basaria","year":"2008","journal-title":"J\u00a0Androl"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib21","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1210\/jc.2007-2595","article-title":"Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosis","volume":"93","author":"Shahani","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib22","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdm056","article-title":"Prevalence of pain in patients with cancer: a systematic review of the past 40 years","volume":"18","author":"van den Beuken-van Everdingen","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejpain.2007.07.006","article-title":"Prevalence, severity, and chronicity of pain and general health-related quality of life in patients with localized prostate cancer","volume":"12","author":"Gerbershagen","year":"2008","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib24","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/sj.bjc.6601654","article-title":"A\u00a0population-based study of pain and quality of life during the year before death in men with prostate cancer","volume":"90","author":"Sandblom","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib25","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib26","first-page":"133","article-title":"Validation of the brief pain inventory for chronic nonmalignant pain","volume":"5","author":"Tan","year":"2004","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib27","first-page":"129","article-title":"Pain assessment: global use of the brief pain inventory","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib28","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1097\/j.pain.0000000000000890","article-title":"Determination of mild, moderate, and severe pain interference in patients with cancer","volume":"158","author":"Shi","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib29","first-page":"556","article-title":"Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera","volume":"10","author":"Arendt-Nielsen","year":"2009","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrrheum.2010.107","article-title":"Assessment of mechanisms in localized and widespread musculoskeletal pain","volume":"6","author":"Graven-Nielsen","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib31","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/ALN.0000000000000465","article-title":"Distraction analgesia in chronic pain patients: the impact of catastrophizing","volume":"121","author":"Schreiber","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib32","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1093\/pm\/pnw010","article-title":"Changes in pain sensitivity and pain modulation during oral opioid treatment: the impact of negative affect","volume":"17","author":"Edwards","year":"2016","journal-title":"Pain Med"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1586\/ern.09.34","article-title":"Pain catastrophizing: a critical review","volume":"9","author":"Quartana","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib35","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nrrheum.2011.2","article-title":"Pain, catastrophizing, and depression in the rheumatic diseases","volume":"7","author":"Edwards","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib36","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1023\/A:1025570508954","article-title":"Factor structure, reliability, and validity of the pain catastrophizing scale","volume":"20","author":"Osman","year":"1997","journal-title":"J\u00a0Behav Med"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib37","series-title":"State-Trait Anxiety Inventory: A Comprehensive Bibliography","author":"Spielberger","year":"1989"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib38","first-page":"200","article-title":"Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency","volume":"7","author":"Daniell","year":"2006","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib39","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1097\/00000542-200306000-00018","article-title":"Postcesarean section pain prediction by preoperative experimental pain assessment","volume":"98","author":"Granot","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib40","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00000542-200509000-00026","article-title":"Predicting postoperative pain by preoperative pressure pain assessment","volume":"103","author":"Hsu","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pain.2007.10.033","article-title":"Prediction of chronic post-operative pain: pre-operative DNIC testing identifies patients at risk","volume":"138","author":"Yarnitsky","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib42","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1200\/JCO.2015.64.1969","article-title":"Association of androgen deprivation therapy with depression in localized prostate cancer","volume":"34","author":"Dinh","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib43","doi-asserted-by":"crossref","first-page":"e0173266","DOI":"10.1371\/journal.pone.0173266","article-title":"Patients receiving androgen deprivation therapy for prostate cancer have an increased risk of depressive disorder","volume":"12","author":"Chung","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/01.pra.0000358315.88931.fc","article-title":"Testosterone and depression: systematic review and meta-analysis","volume":"15","author":"Zarrouf","year":"2009","journal-title":"J\u00a0Psychiatr Pract"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib45","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.psyneuen.2011.03.004","article-title":"Hypogonadism predisposes males to the development of behavioural and neuroplastic depressive phenotypes","volume":"36","author":"Wainwright","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib46","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1506119","article-title":"Effects of testosterone treatment in older men","volume":"374","author":"Snyder","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.eururo.2014.07.010","article-title":"Adverse effects of androgen deprivation therapy and strategies to mitigate them","volume":"67","author":"Nguyen","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib48","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.urology.2008.03.032","article-title":"Falls and physical performance deficits in older patients with prostate cancer undergoing androgen deprivation therapy","volume":"72","author":"Bylow","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.biopsych.2014.12.024","article-title":"The anxiolytic and Antidepressant-like effects of testosterone and estrogen in Gonadectomized male rats","volume":"78","author":"Carrier","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib50","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1006\/hbeh.2002.1838","article-title":"Testosterone rapidly reduces anxiety in male house mice (Mus musculus)","volume":"42","author":"Aikey","year":"2002","journal-title":"Horm Behav"},{"key":"10.1016\/j.jpainsymman.2017.09.017_bib51","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1507\/endocrj.EJ12-0134","article-title":"Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions","volume":"59","author":"Aydogan","year":"2012","journal-title":"Endocr J"}],"container-title":["Journal of Pain and Symptom Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0885392417304967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0885392417304967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:22:25Z","timestamp":1760131345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0885392417304967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0885392417304967"],"URL":"https:\/\/doi.org\/10.1016\/j.jpainsymman.2017.09.017","relation":{},"ISSN":["0885-3924"],"issn-type":[{"value":"0885-3924","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Androgen Deprivation Therapy on Pain Perception, Quality of Life, and Depression in Men With Prostate Cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Pain and Symptom Management","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpainsymman.2017.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc. on behalf of American Academy of Hospice and Palliative Medicine.","name":"copyright","label":"Copyright"}]}}