{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:42:58Z","timestamp":1770410578510,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.jpba.2006.07.018","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T18:15:54Z","timestamp":1156529754000},"page":"586-600","source":"Crossref","is-referenced-by-count":34,"title":["Simultaneous determination of dextromethorphan, dextrorphan, and guaifenesin in human plasma using semi-automated liquid\/liquid extraction and gradient liquid chromatography tandem mass spectrometry"],"prefix":"10.1016","volume":"43","author":[{"given":"Thomas H.","family":"Eichhold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"McCauley-Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa A.","family":"Khambe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Steven H.","family":"Hoke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2006.07.018_bib1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1056\/NEJM195307232490402","volume":"249","author":"Cass","year":"1953","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jpba.2006.07.018_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/jappl.1999.86.3.1017","volume":"86","author":"Bolser","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jpba.2006.07.018_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2125.1995.tb04446.x","volume":"39","author":"Grattan","year":"1995","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2006.07.018_bib4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1046\/j.1365-2125.1999.00029.x","volume":"48","author":"Manap","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2006.07.018_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/030006058301100206","volume":"11","author":"Matthys","year":"1983","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.jpba.2006.07.018_bib6","unstructured":"Expectorant Drug Products for Over-the-Counter Human Use; Final Monograph. U.S. Department of Health and Human Services. Federal Register 54, 1989, pp. 8494\u20138509."},{"key":"10.1016\/j.jpba.2006.07.018_bib7","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1378\/chest.124.6.2178","volume":"124","author":"Dicpinigaitis","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.jpba.2006.07.018_bib8","first-page":"284","volume":"22","author":"Robinson","year":"1977","journal-title":"Curr. Ther. Res."},{"key":"10.1016\/j.jpba.2006.07.018_bib9","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.2042-7158.1998.tb06914.x","volume":"50","author":"von Moltke","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jpba.2006.07.018_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jchromb.2004.09.040","volume":"813","author":"Lutz","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2006.07.018_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0009-9236(96)90056-9","volume":"60","author":"Capon","year":"1996","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2006.07.018_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00008571-199308000-00004","volume":"3","author":"Jacqz-Afgrain","year":"1993","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.jpba.2006.07.018_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/(SICI)1099-081X(199704)18:3<227::AID-BDD18>3.0.CO;2-L","volume":"18","author":"Schmider","year":"1997","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.jpba.2006.07.018_bib14","first-page":"1188","volume":"45","author":"Fossati","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.jpba.2006.07.018_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2125.2003.01853.x","volume":"56","author":"Moghadamnia","year":"2003","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2006.07.018_bib16","first-page":"199","volume":"5","author":"Braga","year":"1994","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.jpba.2006.07.018_bib17","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0731-7085(93)80072-9","volume":"11","author":"Aluri","year":"1993","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2006.07.018_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0378-4347(00)80149-8","volume":"224","author":"Ketelaars","year":"1981","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2006.07.018_bib19","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/jps.2600611226","volume":"61","author":"Vandenheuvel","year":"1972","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2006.07.018_bib20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0731-7085(00)00346-0","volume":"23","author":"McCauley-Myers","year":"2000","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2006.07.018_bib21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00007691-199606000-00014","volume":"18","author":"Hartter","year":"1996","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.jpba.2006.07.018_bib22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1080\/10826079608006317","volume":"19","author":"Kimiskidis","year":"1996","journal-title":"J. Liq. Chromatogr. Rel. Technol."},{"key":"10.1016\/j.jpba.2006.07.018_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0378-4347(85)80074-8","volume":"338","author":"East","year":"1985","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2006.07.018_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00007691-199001000-00018","volume":"12","author":"Chen","year":"1990","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.jpba.2006.07.018_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jps.2600730107","volume":"73","author":"Park","year":"1984","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2006.07.018_bib26","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0731-7085(98)00273-8","volume":"18","author":"Kristensen","year":"1998","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2006.07.018_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5173(83)90092-3","volume":"14","author":"Pfaff","year":"1983","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2006.07.018_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/j.1552-4604.1987.tb02174.x","volume":"27","author":"Woodworth","year":"1987","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2006.07.018_bib29","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/(SICI)1096-9888(199711)32:11<1205::AID-JMS579>3.0.CO;2-C","volume":"32","author":"Eichhold","year":"1997","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2006.07.018_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4347(01)00555-2","volume":"772","author":"Bolden","year":"2002","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2006.07.018_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-4347(97)00308-3","volume":"698","author":"Eichhold","year":"1997","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2006.07.018_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0021-9673(03)00773-8","volume":"1020","author":"Ynddal","year":"2003","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2006.07.018_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0378-4347(00)81585-6","volume":"183","author":"Singhawangcha","year":"1980","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2006.07.018_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jchromb.2004.12.011","volume":"817","author":"Chen","year":"2005","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2006.07.018_bib35","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0731-7085(95)01506-G","volume":"13","author":"Stavchansky","year":"1995","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2006.07.018_bib36","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1255\/ejms.737","volume":"11","author":"Kuhlenbeck","year":"2005","journal-title":"Eur. J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2006.07.018_bib37","unstructured":"Guidance for Industry, Bioanalytical Method Validation, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine, Rockville, MD, 2001. Available at http:\/\/www.fda.gov\/cder\/guidance\/index.htm."},{"key":"10.1016\/j.jpba.2006.07.018_bib38","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1021\/ac0014820","volume":"73","author":"Hoke","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2006.07.018_bib39","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1021\/ac000068x","volume":"72","author":"Hoke","year":"2000","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2006.07.018_bib40","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1021\/ac0006876","volume":"73","author":"van Pelt","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2006.07.018_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/rcm.539","volume":"16","author":"King","year":"2002","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2006.07.018_bib42","first-page":"64","volume":"4","author":"Rudewicz","year":"2001","journal-title":"Am. Pharm. Rev."},{"key":"10.1016\/j.jpba.2006.07.018_bib43","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/rcm.688","volume":"16","author":"Deng","year":"2002","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2006.07.018_bib44","first-page":"270","volume":"12","author":"Hull","year":"2002","journal-title":"Eur. Respir. Rev."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708506004663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708506004663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T17:00:30Z","timestamp":1555779630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708506004663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0731708506004663"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2006.07.018","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}