{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:13:18Z","timestamp":1791526398440,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.jpba.2010.02.032","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T14:44:25Z","timestamp":1267713865000},"page":"151-157","source":"Crossref","is-referenced-by-count":16,"title":["Comparative study on the analytical performance of different detectors for the liquid chromatographic analysis of tobramycin"],"prefix":"10.1016","volume":"53","author":[{"given":"Shruti","family":"Chopra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Vanderheyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Hoogmartens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Van Schepdael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2010.02.032_bib1","unstructured":"European Pharmacopoeia, 6th ed., EDQM, Strasbourg, 2009, pp. 3854\u20133855."},{"key":"10.1016\/j.jpba.2010.02.032_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1570-0232(02)00544-5","article-title":"Trace analysis of tobramycin in human plasma by derivatization and high performance liquid chromatography with ultraviolet detection","volume":"780","author":"Feng","year":"2002","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2010.02.032_bib3","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/1522-2683(200206)23:11<1695::AID-ELPS1695>3.0.CO;2-6","article-title":"Development and validation of a capillary electrophoresis method for tobramycin with pre-capillary derivatization and UV detection","volume":"23","author":"Kaale","year":"2002","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jpba.2010.02.032_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jchromb.2008.05.012","article-title":"Development and validation of HPLC method for the determination of tobramycin in urine samples post-inhalation using pre-column derivatization with fluorescein isothiocyanate","volume":"869","author":"Mashat","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2010.02.032_bib5","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/0731-7085(89)80185-2","article-title":"Determination of aminoglycosides in pharmaceutical formulations\u2013II. High performance liquid chromatography","volume":"7","author":"Fabre","year":"1989","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2010.02.032_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jchromb.2008.12.011","article-title":"Detemination of kanamycin A, amikacin and tobramycin in milk residues by capillary zone electrophoresis with post-column derivatization and laser induced fluorescence detection","volume":"877","author":"Chang-Zhu","year":"2009","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2010.02.032_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0021-9673(01)81339-X","article-title":"Liquid chromatographic separation of aminoglycosides with pulsed amperometric detection","volume":"324","author":"Polta","year":"1985","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2010.02.032_bib8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0378-4347(00)82108-8","article-title":"Determination of tobramycin using high performance liquid chromatography with pulsed amperometric detection","volume":"527","author":"Statler","year":"1990","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2010.02.032_bib9","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0731-7085(00)00357-5","article-title":"Analysis of tobramycin by liquid chromatography with pulsed electrochemical detection","volume":"23","author":"Szunyog","year":"2000","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2010.02.032_bib10","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jpba.2005.08.009","article-title":"Determination of tobramycin and impurities using high performance anion exchange chromatography with integrated pulsed amperometric detection","volume":"40","author":"Hanko","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2010.02.032_bib11","doi-asserted-by":"crossref","unstructured":"V.P. Hanko, J.S. Rohrer, H.H. Liu, C. Zheng, S. Zhang, X. Liu, 421 X. Tang, Identification of tobramycin impurities for quality control process monitoring using high performance anion exchange chromatography with integrated pulsed amperometric detection, J. Pharm. Biomed. Anal. 47 (2008) 828\u2013823.","DOI":"10.1016\/j.jpba.2008.04.002"},{"key":"10.1016\/j.jpba.2010.02.032_bib12","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF02493134","article-title":"The rapid determination of tobramycin in microlitre quantities of human tear fluid using LC\u2013MS-MS","volume":"52","author":"Rees","year":"2000","journal-title":"Chromatographia"},{"key":"10.1016\/j.jpba.2010.02.032_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.aca.2006.04.038","article-title":"Measurement of tobramycin by reversed phase high-performance liquid chromatography with mass spectrometry detection","volume":"571","author":"Guo","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2010.02.032_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jchromb.2007.12.008","article-title":"Simple and sensitive method for quantification of low tobramycin concentrations in human plasma using HPLC\u2013MS\/MS","volume":"862","author":"Attema-de-Jonge","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2010.02.032_bib15","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1016\/j.chroma.2009.03.023","article-title":"Characterization of impurities in tobramycin by liquid chromatography\u2013mass spectrometry","volume":"1216","author":"Li","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2010.02.032_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jpba.2009.09.002","article-title":"Development and validation of a RP-HPLC method for the determination of gentamicin sulfate and its related substances in a pharmaceutical cream using a short pentafluorophenyl column and a charged aerosol detector","volume":"51","author":"Joseph","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2010.02.032_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.chroma.2008.07.080","article-title":"Comparison between charged aerosol detection and light scattering detection for analysis of Leishmania membrane phospholipids","volume":"1209","author":"Ramos","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2010.02.032_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00216-004-2948-8","article-title":"Development and validation of a novel HPLC\/ELSD method for the indirect determination of tobramycin in pharmaceuticals, plasma and urine","volume":"382","author":"Megoulas","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2010.02.032_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jpba.2009.03.013","article-title":"Simultaneous quantitation of tobramycin and colistin sulphate by HPLC with evaporative light scattering detection","volume":"50","author":"Clarot","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2010.02.032_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.chroma.2004.08.158","article-title":"Hydrophilic interaction chromatography combined with tandem-mass spectrometry to determine six aminoglycosides in serum","volume":"1058","author":"Oertel","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2010.02.032_bib21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jpba.2006.06.043","article-title":"Improved reversed-phase liquid chromatographic method combined with pulsed electrochemical detection for the analysis of amikacin","volume":"43","author":"Zawilla","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2010.02.032_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.chroma.2007.12.041","article-title":"Improved liquid chromatographic method with pulsed electrochemical detection for the analysis of gentamicin","volume":"1189","author":"Manyanga","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2010.02.032_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jchromb.2008.03.016","article-title":"Determination of amikacin in cerebrospinal fluid by high-performance liquid chromatography with pulsed electrochemical detection","author":"Brajanoski","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2010.02.032_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chroma.2003.12.051","article-title":"Optimizing the quadruple potential waveform for the pulsed amperometric detection of neomycin","volume":"1039","author":"Ding","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2010.02.032_bib25","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1021\/ac9811524","article-title":"An integrated amperometry waveform for direct, sensitive detection of amino acids and amino sugars following anion-exchange chromatography","volume":"71","author":"Clarke","year":"1999","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2010.02.032_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chroma.2005.01.086","article-title":"Comparative study on the analytical performance of three waveforms for the determination of several aminoglycoside antibiotics with high performance liquid chromatography with amperometric detection","volume":"1085","author":"Cai","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2010.02.032_bib27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.chroma.2007.10.111","article-title":"Performance evaluation of evaporative light scattering detection and charged aerosol detection in reversed phase liquid chromatography","volume":"1189","author":"Vervoort","year":"2008","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708510001184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708510001184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T16:35:29Z","timestamp":1558888529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708510001184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0731708510001184"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2010.02.032","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}