{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:00:11Z","timestamp":1786993211822,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.jpba.2011.03.034","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T19:23:56Z","timestamp":1302809036000},"page":"964-971","source":"Crossref","is-referenced-by-count":6,"title":["Liquid chromatography\u2013tandem mass spectrometry method for measurement of nicotine N-glucuronide: A marker for human UGT2B10 inhibition"],"prefix":"10.1016","volume":"55","author":[{"given":"Jian","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diansong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 1","key":"10.1016\/j.jpba.2011.03.034_bib0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj3030233","article-title":"Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation","volume":"303","author":"Senafi","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.jpba.2011.03.034_bib0010","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1128\/AAC.42.7.1592","article-title":"Glucuronidation of 3\u2032-azido-3\u2032-deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid","volume":"42","author":"Trapnell","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jpba.2011.03.034_bib0015","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1021\/tx050317i","article-title":"Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity","volume":"19","author":"Mutlib","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jpba.2011.03.034_bib0020","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/01.fpc.0000173483.13689.56","article-title":"Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily","volume":"15","author":"Mackenzie","year":"2005","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.jpba.2011.03.034_bib0025","doi-asserted-by":"crossref","first-page":"36164","DOI":"10.1074\/jbc.M002180200","article-title":"Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine","volume":"275","author":"Strassburg","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpba.2011.03.034_bib0030","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/sj.onc.1209375","article-title":"Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer","volume":"25","author":"Nagar","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jpba.2011.03.034_bib0035","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1124\/dmd.30.12.1484","article-title":"Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes","volume":"30","author":"Nakajima","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2011.03.034_bib0040","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1124\/dmd.105.007369","article-title":"Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) \u201cprobes\u201d for human udp-glucuronosyltransferases","volume":"34","author":"Uchaipichat","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2011.03.034_bib0045","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1124\/dmd.109.030981","article-title":"Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine","volume":"38","author":"Zhou","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2011.03.034_bib0050","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1124\/mol.107.037093","article-title":"Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10","volume":"72","author":"Kaivosaari","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jpba.2011.03.034_bib0055","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1124\/dmd.107.019406","article-title":"Glucuronidation of tobacco-specific nitrosamines by UGT2B10","volume":"36","author":"Chen","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2011.03.034_bib0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0076-6879(05)00007-8","article-title":"Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases","volume":"400","author":"Court","year":"2005","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jpba.2011.03.034_bib0065","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ddtec.2006.03.007","article-title":"New technologies for assessing UDP-glucuronosyltransferases (UGT) metabolism in drug discovery and development","volume":"3","author":"Patten","year":"2006","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.jpba.2011.03.034_bib0070","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.bcp.2007.11.008","article-title":"Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation","volume":"75","author":"Hashizume","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jpba.2011.03.034_bib0075","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/dmd.107.017962","article-title":"Characterization of 1\u2032-hydroxymidazolam glucuronidation in human liver microsomes","volume":"36","author":"Zhu","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2011.03.034_bib0080","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF02269897","article-title":"Evaluation of capillary electrophoresis of the analysis of nicotine and selective minor alkaloids from tobacco","volume":"40","author":"Yang","year":"1995","journal-title":"Chromatographia"},{"key":"10.1016\/j.jpba.2011.03.034_bib0085","first-page":"1525","article-title":"Formation of the quaternary ammonium-linked glucuronide of nicotine in human liver microsomes: identification and stereoselectivity in the kinetics","volume":"29","author":"Ghosheh","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2011.03.034_bib0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0021-9673(01)01328-0","article-title":"Studies of signal suppression in liquid chromatography\u2013electrospray ionization mass spectrometry using volatile ion-pairing reagents","volume":"937","author":"Gustavsson","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2011.03.034_bib0095","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1124\/dmd.31.11.1361","article-title":"N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases","volume":"31","author":"Kuehl","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2011.03.034_bib0100","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jchromb.2009.12.018","article-title":"A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography\u2013electrospray ionization-tandem mass spectrometry","volume":"878","author":"Miller","year":"2010","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708511001865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708511001865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T04:07:54Z","timestamp":1592453274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708511001865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0731708511001865"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2011.03.034","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}