{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:17:47Z","timestamp":1777436267320,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.jpba.2011.10.024","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T17:35:03Z","timestamp":1319823303000},"page":"51-58","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation"],"prefix":"10.1016","volume":"60","author":[{"given":"Jochen","family":"Pauwels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ward","family":"D\u2019Autry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Van den Bossche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9dric","family":"Dewever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Forier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Vandenwaeyenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Wolfs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos","family":"Hoogmartens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Van Schepdael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2011.10.024_bib0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0306-4522(81)90136-6","article-title":"Immunoreactive substance-P in sympathetic-ganglia - distribution and sensitivity towards capsaicin","volume":"6","author":"Gamse","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpba.2011.10.024_bib0010","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0731-7085(96)01858-4","article-title":"Evaluation of the quality of Nigerian chillies for pharmaceutical formulations","volume":"15","author":"Gbolade","year":"1997","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2011.10.024_bib0015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrd2757","article-title":"Transient receptor potential channels: targeting pain at the source","volume":"8","author":"Patapoutian","year":"2009","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.jpba.2011.10.024_bib0020","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1086\/317510","article-title":"Brief history of antipyretic therapy","volume":"31","author":"Mackowiak","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jpba.2011.10.024_bib0025","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/bmj.38040.607141.EE","article-title":"Systematic review of topical rubefacients containing salicylates for the treatment of acute and chronic pain","volume":"328","author":"Mason","year":"2004","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jpba.2011.10.024_bib0030","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1523\/JNEUROSCI.2574-05.2005","article-title":"Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism","volume":"25","author":"Xu","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jpba.2011.10.024_bib0035","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal action of menthol on the transient receptor potential channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jpba.2011.10.024_bib0040","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.chroma.2008.10.053","article-title":"Analysis of capsaicin and dihydrocapsaicin in peppers and pepper sauces by solid phase microextraction\u2013gas chromatography\u2013mass spectrometry","volume":"1216","author":"Pena-Alvarez","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2011.10.024_bib0045","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1021\/jf0620261","article-title":"Determination of capsaicin and dihydrocapsaicin in Capsicum fruits by liquid chromatography-electrospray\/time-of-flight mass spectrometry","volume":"54","author":"Garces-Claver","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpba.2011.10.024_bib0050","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9673(98)00969-8","article-title":"Determination of capsaicin and dihydrocapsaicin my micellar electrokinetic capillary chromatography and its application to various species of Capsicum, Solanaceae","volume":"838","author":"Laskaridou-Monnerville","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2011.10.024_bib0055","first-page":"1515","article-title":"Comparison of extraction procedures for the determination of capsaicinoids in peppers","volume":"18","author":"Jeon","year":"2009","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.jpba.2011.10.024_bib0060","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0731-7085(02)00476-4","article-title":"Determination of capsaicinoids in topical cream by liquid\u2013liquid extraction and liquid chromatography","volume":"30","author":"Kaale","year":"2002","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2011.10.024_bib0065","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0731-7085(01)00564-7","article-title":"Simultaneous analysis of dehydroacetic acid, benzoic acid, sorbic acid and salicylic acid in cosmetic products by solid-phase extraction and high performance liquid chromatography","volume":"28","author":"Mikami","year":"2002","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2011.10.024_bib0070","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jpba.2009.05.015","article-title":"Development and validation of a stability-indicating HPLC method for simultaneous determination of salicylic acid, betamethasone dipropionate in their related compounds in Diprosalic lotion (R)","volume":"50","author":"Shou","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2011.10.024_bib0075","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejps.2006.11.009","article-title":"Influence of particle size on the quantitative determination of salicylic acid in a pharmaceutical ointment using FT-Raman spectroscopy","volume":"30","author":"De Beer","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2011.10.024_bib0080","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/jps.2600830532","article-title":"Comparison of 3 new spectrophotometric methods for simultaneous determination of aspirin and salicylic acid in tablets without separation of pharmaceutical excipients","volume":"83","author":"Glombitza","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2011.10.024_bib0085","first-page":"541","article-title":"Simultaneous determination of acetyl salicylic acid and acetaminophen in acetaminophen-caffeine-aspirin (ACA) tablets by FT-IR\/ATR spectrometry with multivariate calibration data treatment","volume":"17","author":"Sohrabi","year":"2005","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.jpba.2011.10.024_bib0090","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0021-9673(00)82732-6","article-title":"Gas\u2013liquid-chromatographic assay of mixtures of camphor, menthol, and methyl salicylate in ointments","volume":"238","author":"Tan","year":"1982","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2011.10.024_bib0095","first-page":"322","article-title":"Simultaneous determination of camphor, menthol, methyl salicylate, and thymol in analgesic ointments by gas\u2013liquid-chromatography","volume":"8","author":"Pant","year":"1990","journal-title":"LC\u2013GC"},{"key":"10.1016\/j.jpba.2011.10.024_bib0100","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jps.2600680431","article-title":"Simultaneous GLC-determination of methyl salicylate and menthol in a topical analgesic formulation","volume":"68","author":"Sapio","year":"1979","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2011.10.024_bib0105","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jpba.2008.04.006","article-title":"Static headspace gas chromatography of (semi-)volatile drugs in pharmaceuticals for topical use","volume":"47","author":"Sitaramaraju","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2011.10.024_bib0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jchromb.2003.10.022","article-title":"Determination of menthol in plasma and urine of rats and humans by headspace solid phase microextraction and gas chromatography-mass spectrometry","volume":"799","author":"Spichiger","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2011.10.024_bib0115","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.aca.2009.05.010","volume":"646","author":"Schulz","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2011.10.024_bib0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0021-9673(99)00139-9","article-title":"Determination of menthol and menthone in food and pharmaceutical products by solid-phase microextraction-gas chromatography","volume":"847","author":"Ligor","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2011.10.024_bib0125","series-title":"Static Headspace - Gas Chromatography: Theory and Practice","author":"Kolb","year":"1997"},{"key":"10.1016\/j.jpba.2011.10.024_bib0130","unstructured":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use: Q2(R1): Validation of Analytical Procedures: Text and Methodology, Geneva, 1994."},{"key":"10.1016\/j.jpba.2011.10.024_bib0135","series-title":"Quantitative Chemical Analysis","author":"Harris","year":"2007"},{"key":"10.1016\/j.jpba.2011.10.024_bib0140","unstructured":"Monograph 2336: capsicum oleoresin, in: European Pharmacopoeia, 6th ed., European Department for the Quality of Medicines, Strasbourg, 2010, pp. 1405\u20131406."},{"key":"10.1016\/j.jpba.2011.10.024_bib0145","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.aca.2005.10.032","article-title":"Characterization of major and minor capsaicinoids and related compounds in chili pods (Capsicum frutescens L.) by high-performance liquid chromatography\/atmospheric pressure chemical ionization mass spectrometry","volume":"557","author":"Schweiggert","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2011.10.024_bib0150","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/bmc.1107","article-title":"Quantitative determination of capsaicin, a transient receptor potential channel vanilloid 1 agonist, by liquid chromatography quadrupole ion trap mass spectrometry: evaluation of in vitro metabolic stability","volume":"23","author":"Beaudry","year":"2009","journal-title":"Biomed. Chromatogr."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708511006169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708511006169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T03:53:56Z","timestamp":1543463636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708511006169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":30,"alternative-id":["S0731708511006169"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2011.10.024","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}