{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:52:26Z","timestamp":1778651546506,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jpba.2012.11.029","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T22:09:48Z","timestamp":1353967788000},"page":"94-104","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Impurity profiling of micronomicin sulfate injection by liquid chromatography\u2013ion trap mass spectrometry"],"prefix":"10.1016","volume":"75","author":[{"given":"Yao-zuo","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia-Lei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-qin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-hong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Van Schepdael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos","family":"Hoogmartens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2012.11.029_bib0005","doi-asserted-by":"crossref","first-page":"793","DOI":"10.7164\/antibiotics.27.793","article-title":"A new antibiotic XK-62-2 (sagamicin) I. Isolation, physicochemical and antibacterial properties","volume":"27","author":"Okachi","year":"1974","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7164\/antibiotics.28.35","article-title":"The gentamicin antibiotics: gentamicin C2b, an aminoglycoside antibiotic produced by Micromonospora purpurea mutant JI-33","volume":"28","author":"Daniels","year":"1975","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0015","first-page":"94","article-title":"Studies on sagamicin produced by M. echinospora mutant strain III. Isolation, physicochemical and biological properties of antibiotics 401-B","volume":"9","author":"Zhao","year":"1984","journal-title":"Chin. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7164\/antibiotics.28.21","article-title":"New antibiotic XK-62-2 (sagamicin) II. Taxonomy of the producing organism, fermentative production and characterization of sagamicin","volume":"28","author":"Nara","year":"1975","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0025","first-page":"285","article-title":"Studies on sagamicin produced by Micromonospora echinospora mutant strain I. Taxonomical identification of M. echinospora. JIM-401","volume":"8","author":"Zhao","year":"1983","journal-title":"Chin. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0030","first-page":"90","article-title":"Studies on sagamicin produced by Micromonospora echinospora mutant strain II. Selection and fermentation of M. echinospora. JIM-401","volume":"9","author":"Zhao","year":"1984","journal-title":"Chin. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7164\/antibiotics.35.1","article-title":"Sagamicin and the related aminoglycosides: fermentation and biosynthesis I. Biosynthetic studies with the blocked mutants of Micromonospora sagamiensis","volume":"35","author":"Kase","year":"1981","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0040","series-title":"Pharmacopoeia of the People's Republic of China","year":"2010"},{"key":"10.1016\/j.jpba.2012.11.029_bib0045","first-page":"260","article-title":"Separation of micronomycin and related components by high performance liquid chromatography","volume":"15","author":"Mi","year":"1990","journal-title":"Chin. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0050","first-page":"264","article-title":"Analysis of home-made micronomicin by reversed-phase high-performance liquid chromatography","volume":"15","author":"Huang","year":"1990","journal-title":"Chin. J. Antibiot."},{"key":"10.1016\/j.jpba.2012.11.029_bib0055","first-page":"205","article-title":"Analysis of micronomycin (sagamicin) and its related substances by HPLC\u2013ELSD","volume":"22","author":"Wang","year":"2002","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.jpba.2012.11.029_bib0060","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/rcm.3936","article-title":"Analysis of impurities in streptomycin and dihydrostreptomycin by hydrophilic interaction chromatography\/electrospray ionization quadrupole ion trap\/time-of-flight mass spectrometry","volume":"23","author":"Kawano","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2012.11.029_bib0065","first-page":"31","article-title":"Rapid characterization of the related substances in micronomicin sulfate by HPLC\u2013ESI\u2013IT\u2013MSn","volume":"18","author":"Yuan","year":"2010","journal-title":"Pharm. Clin. Res."},{"key":"10.1016\/j.jpba.2012.11.029_bib0070","first-page":"1050","article-title":"Analyse the aminoglycoside antibiotics by MSn","volume":"26","author":"Yang","year":"2006","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.jpba.2012.11.029_bib0075","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/rcm.2317","article-title":"Analysis of unknown compounds in gentamicin bulk samples with liquid chromatography coupled with ion trap mass spectrometry","volume":"20","author":"Li","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2012.11.029_bib0080","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1002\/rcm.3748","article-title":"Characterization of impurities in sisomicin and netilmicin by liquid chromatography\/mass spectrometry","volume":"22","author":"Li","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2012.11.029_bib0085","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1016\/j.chroma.2009.03.023","article-title":"Characterization of impurities in tobramycin by liquid chromatography\u2013mass spectrometry","volume":"1216","author":"Li","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2012.11.029_bib0090","first-page":"817","article-title":"Characterization of related substances in etimicin sulfate sample by high performance liquid chromatography\u2013electrospray ionization\u2013ion trap\u2013mass spectrometry","volume":"38","author":"Yuan","year":"2010","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.jpba.2012.11.029_bib0095","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jpba.2009.06.004","article-title":"Identification of gentamicin impurities by liquid chromatography tandem mass spectrometry","volume":"50","author":"Grahek","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2012.11.029_bib0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jpba.2011.01.017","article-title":"Mass spectrometric characterization of gentamicin components separated by the new European Pharmacopoeia method","volume":"55","author":"Li","year":"2011","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708512006449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708512006449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T00:28:30Z","timestamp":1540081710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708512006449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":20,"alternative-id":["S0731708512006449"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2012.11.029","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}