{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:17:25Z","timestamp":1773281845804,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jpba.2014.08.023","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T00:35:36Z","timestamp":1412382936000},"page":"346-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Development of a method to quantify clindamycin in vitreous humor of rabbits\u2019 eyes by UPLC\u2013MS\/MS: Application to a comparative pharmacokinetic study and in vivo ocular biocompatibility evaluation"],"prefix":"10.1016","volume":"102","author":[{"given":"Gabriella M.","family":"Fernandes-Cunha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayana Rubio","family":"Gouvea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo de Oliveira","family":"Fulg\u00eancio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00edntia M.F.","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Rodrigues","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana M.","family":"Bretas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia Lig\u00f3rio","family":"Fialho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto Peporine","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Silva-Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2014.08.023_bib0005","series-title":"Focal Points: Clinical Modules for Ophthalmologists","first-page":"1","article-title":"Ocular toxoplasmosis: clinical presentations, diagnosis and therapy","author":"Dodds","year":"1999"},{"key":"10.1016\/j.jpba.2014.08.023_bib0010","first-page":"1","article-title":"Ocular toxoplasmosis: a global reassessment. Part II: disease manifestation and management","volume":"137","author":"Holland","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.jpba.2014.08.023_bib0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/092739490500174","article-title":"Patterns of uveitis in a tertiary eye care center in Iran","volume":"12","author":"Soheilian","year":"2004","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.jpba.2014.08.023_bib0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1006129422690","article-title":"Successful management of ocular toxoplasmosis during pregnancy using combined intraocular clindamycin and dexamethasone with systemic sulfadiazine","volume":"22","author":"Martinez","year":"1998","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.jpba.2014.08.023_bib0025","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3928\/1542-8877-20010501-03","article-title":"Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis","volume":"32","author":"Kishore","year":"2001","journal-title":"Ophthal. Surg. Lasers"},{"key":"10.1016\/j.jpba.2014.08.023_bib0030","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1097\/IAE.0b013e31804b3f0d","article-title":"Intravitreal clindamycin for toxoplasmosis retinochoroiditis","volume":"27","author":"Sobrin","year":"2007","journal-title":"Retina"},{"key":"10.1016\/j.jpba.2014.08.023_bib0035","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ophtha.2010.04.020","article-title":"Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis","volume":"118","author":"Soheilian","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jpba.2014.08.023_bib0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0896-1549(02)00030-5","article-title":"Ocular toxoplasmosis","volume":"15","author":"Hovakimyan","year":"2002","journal-title":"Ophthalmol. Clin North Am."},{"key":"10.1016\/j.jpba.2014.08.023_bib0045","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0161-6420(03)00083-6","article-title":"Antibiotics for toxoplasmic retinochoroiditis: an evidence-based systematic review","volume":"110","author":"Stanford","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jpba.2014.08.023_bib0050","first-page":"586","article-title":"Implant as drug delivery devices for the treatment of eye diseases","volume":"46","author":"da Silva","year":"2010","journal-title":"Braz. J. Pharmaceut. Sci."},{"key":"10.1016\/j.jpba.2014.08.023_bib0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0168-3659(95)00074-I","article-title":"Controlled intra-ocular delivery of ganciclovir with use of biodegradable scleral implant in rabbits","volume":"37","author":"Kunou","year":"1995","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpba.2014.08.023_bib0060","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00006982-200602000-00015","article-title":"Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal drug deliver system of all-trans retinoic acid","volume":"26","author":"Dong","year":"2006","journal-title":"Retina"},{"key":"10.1016\/j.jpba.2014.08.023_bib0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.drudis.2007.11.002","article-title":"Current and future ophthalmic drug delivery systems: a shift to the posterior segment","volume":"13","author":"Amo","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jpba.2014.08.023_bib0070","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1016\/j.chroma.2009.08.061","article-title":"Characterization and classification of matrix effects in biological samples analyses","volume":"1217","author":"Marchi","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2014.08.023_bib0075","series-title":"Validation of Analytical Procedures: Definitions and Terminology","author":"ICH","year":"1996"},{"key":"10.1016\/j.jpba.2014.08.023_bib0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpba.2013.10.025","article-title":"Determination of triamcinolone acetonide in silicone oil and aqueous humor of vitrectomized rabbits\u2019eyes: Application for a pharmacokinetic study with intravitreal triamcinolone acetonide injections (Kenalog\u00ae40)","volume":"89","author":"Fernandes-Cunha","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2014.08.023_bib0085","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/bmc.517","article-title":"Simple method for the assay of clindamycin in human plasma by reversed-phase high-performance liquid chromatography with UV detector","volume":"19","author":"Cho","year":"2005","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2014.08.023_bib0090","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1055\/s-0031-1296241","article-title":"Comparative pharmacokinetics study of two different clindamycin capsule formulations: a randomized, two-period, two-sequence, two-way crossover clinical trial in healthy volunteers","volume":"61","author":"Sanki","year":"2011","journal-title":"Arzneimittel-Forsch."},{"key":"10.1016\/j.jpba.2014.08.023_bib0095","first-page":"358","article-title":"Pharmacokinetics and bioequivalence study of clindamycin hydrochloride formulations after single-dose administration in healthy Chinese male volunteers","volume":"58","author":"Li","year":"2008","journal-title":"Arzneimittel-Forsch."},{"key":"10.1016\/j.jpba.2014.08.023_bib0100","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jpba.2009.02.005","article-title":"A fast reverse-phase high performance liquid chromatographic tandem mass spectrometry assay for the quantification of clindamycin in plasma and saliva using a rapid resolution package","volume":"50","author":"Catena","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2014.08.023_bib0105","first-page":"1","article-title":"In vitro anti-Toxoplasma gondii activity of root extract\/fractions of Eurycoma longifolia jack","volume":"91","author":"Kavitha","year":"2012","journal-title":"BMC Complement. Alter. Med."},{"key":"10.1016\/j.jpba.2014.08.023_bib0110","article-title":"Study in vivo intraocular biocompatiblity of in situ gelation hydrogels: poly(2-ethyl oxazoline)-block-poly(e-caprolactone)-block-poly(2-ethyloxazoline) copolymer, matrigel and pluronic F127","volume":"8","author":"Hwang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2014.08.023_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028720","article-title":"Intraocular pressure changes: an important determinant of the biocompatibility of intravitreal implants","volume":"6","author":"Zou","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2014.08.023_bib0120","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2147\/DDDT.S53759","article-title":"Biodegradable in situ gelling delivery systems containing pilocarpine as new antiglaucoma formulations: effect of a mercaptoacetic acid\/N-isopropylacrylamide molar ratio","volume":"7","author":"Lai","year":"2013","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jpba.2014.08.023_bib0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12348-012-0064-z","article-title":"Long-term follow-up patients treated with multiple fluocinolone acetonide implants for noninfectious uveitis","volume":"2","author":"Allen","year":"2012","journal-title":"J. Ophthal. Inflamm. Infect."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708514004075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708514004075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T22:59:47Z","timestamp":1650322787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708514004075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":25,"alternative-id":["S0731708514004075"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2014.08.023","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a method to quantify clindamycin in vitreous humor of rabbits\u2019 eyes by UPLC\u2013MS\/MS: Application to a comparative pharmacokinetic study and in vivo ocular biocompatibility evaluation","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2014.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}