{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:24:37Z","timestamp":1777613077909,"version":"3.51.4"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173405"],"award-info":[{"award-number":["81173405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International S&T Cooperation Program of China","award":["2014DFA31440"],"award-info":[{"award-number":["2014DFA31440"]}]},{"name":"National Science and Technology Major Project","award":["2014ZX10005001"],"award-info":[{"award-number":["2014ZX10005001"]}]},{"name":"National Science and Technology Major Project","award":["2012ZX10004301-004"],"award-info":[{"award-number":["2012ZX10004301-004"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2012M520921"],"award-info":[{"award-number":["2012M520921"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Postdoctoral Sustentation Fund","award":["12R21415400"],"award-info":[{"award-number":["12R21415400"]}]},{"name":"Program for Outstanding Medical Academic Leader of Shanghai Municipality","award":["LJ10005"],"award-info":[{"award-number":["LJ10005"]}]},{"name":"E-Institute","award":["E03008"],"award-info":[{"award-number":["E03008"]}]},{"name":"Innovative Research Team in Universities of Shanghai Municipal Education Commission and Key Disciplines of Liver and Gall Bladder Diseases of State Administration of TCM China"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jpba.2015.05.014","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T08:08:52Z","timestamp":1432714132000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe"],"prefix":"10.1016","volume":"114","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Yan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2015.05.014_bib0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1749-8546-4-12","article-title":"Effect of Fuzheng Huayu formula and its actions against liver fibrosis","volume":"4","author":"Liu","year":"2009","journal-title":"Chin. Med."},{"key":"10.1016\/j.jpba.2015.05.014_bib0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1749-8546-4-12","article-title":"Effect of Fuzheng Huayu formula and its actions against liver fibrosis","volume":"4","author":"Liu","year":"2009","journal-title":"Chin. Med."},{"key":"10.1016\/j.jpba.2015.05.014_bib0080","first-page":"854","article-title":"Identification of the lignans components after oral administration of Fuzheng Huayu decoction in rat serum by HPLC\u2013MSn","volume":"36","author":"Shen","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jpba.2015.05.014_bib0085","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jep.2013.05.031","article-title":"Investigation of the absorbed and metabolized components of Danshen from Fuzheng Huayu recipe and study on the anti-hepatic fibrosis effects of these components","volume":"148","author":"Yang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2015.05.014_bib0090","doi-asserted-by":"crossref","first-page":"160726","DOI":"10.1155\/2012\/160726","article-title":"Salvianolic acid B attenuates rat hepatic fibrosis via downregulating angiotensin II signaling","volume":"2012","author":"Li","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jpba.2015.05.014_bib0095","first-page":"58","article-title":"Uniform designed research on the active ingredients assembling of Chinese medicine prescription for anti-liver fibrosis","volume":"30","author":"Li","year":"2010","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.jpba.2015.05.014_bib0100","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jpba.2015.05.014_bib0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jpba.2013.08.043","article-title":"Comparative tissue distribution profiles of five major bio-active components in normal and blood deficiency rats after oral administration of Danggui Buxue Decoction by UPLC-TQ\/MS","volume":"88","author":"Shi","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.05.014_bib0110","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.fitote.2012.08.007","article-title":"Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract","volume":"83","author":"Deng","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jpba.2015.05.014_bib0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jpba.2013.01.011","article-title":"Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography\/electrospray ionization mass spectrometry","volume":"77","author":"Yang","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.05.014_bib0120","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jep.2012.06.005","article-title":"A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation","volume":"142","author":"Chen","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2015.05.014_bib0125","first-page":"214","article-title":"Simultaneous determination of 12 major components in Fuzheng Huayu Capsules by UPLC\u2013MS\/MS","volume":"45","author":"Liu","year":"2014","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jpba.2015.05.014_bib0130","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1386-6346(99)00068-6","article-title":"Hepatic fibrosis and cytochrome P450: experimental models of fibrosis compared to AHR knockout mice","volume":"17","author":"Peterson","year":"2000","journal-title":"Hepatol. Res."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515003003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515003003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T16:36:51Z","timestamp":1566751011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708515003003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":13,"alternative-id":["S0731708515003003"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2015.05.014","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2015.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}