{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:21:41Z","timestamp":1787170901851,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jpba.2015.06.018","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T05:45:32Z","timestamp":1434260732000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Development and validation of an UPLC\u2013MS\/MS method for the quantification of tamoxifen and its main metabolites in human scalp hair"],"prefix":"10.1016","volume":"114","author":[{"given":"Jan C.","family":"Drooger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Jager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ho","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilda D.","family":"den Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sleijfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron H.J.","family":"Mathijssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"de Bruijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2015.06.018_bib0005","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0140-6736(97)11423-4","article-title":"Tamoxifen for early breast cancer: an overview of the randomised trial","volume":"351","author":"EBCTCG","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2015.06.018_bib0010","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0140-6736(05)66544-0","article-title":"Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials","volume":"365","author":"EBCTCG","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2015.06.018_bib0015","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1200\/JCO.2005.03.0783","article-title":"Tamoxifen after adjuvant chemotherapy for premenopausal women with lymph node-positive breast cancer: International Breast Cancer Study Group Trial 13\u201393","volume":"24","author":"Colleoni","year":"2006","journal-title":"J. Clin.Oncol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0020","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1200\/JCO.2001.19.2.343","article-title":"Combined tamoxifen and luteinizing hormone-releasing hormone (LHRH) agonist versus LHRH agonist alone in premenopausal advanced breast cancer: a meta-analysis of four randomized trials","volume":"19","author":"Klijn","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/B:BREA.0000025420.78346.f9","volume":"85","author":"Th\u00fcrlimann","year":"2004","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jpba.2015.06.018_bib0030","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/S0140-6736(13)60140-3","article-title":"Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data","volume":"381","author":"Cuzick","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2015.06.018_bib0035","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/djg108","article-title":"Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine","volume":"95","author":"Stearns","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jpba.2015.06.018_bib0040","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1200\/JCO.2005.03.3266","article-title":"Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes","volume":"23","author":"Goetz","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0045","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/clpt.2012.94","article-title":"Individualization of tamoxifen treatment for breast carcinoma","volume":"92","author":"Binkhorst","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2015.06.018_bib0050","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10549-012-2114-5","article-title":"Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: a systematic review","volume":"134","author":"Murphy","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jpba.2015.06.018_bib0055","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrclinonc.2014.40","article-title":"Determining the optimal dose in the development of anticancer agents","volume":"11","author":"Mathijssen","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0060","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ctrv.2015.01.002","article-title":"Individualization of tamoxifen therapy: much more than just CYP2D6 genotyping","volume":"41","author":"Binkhorst","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.jpba.2015.06.018_bib0065","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1023\/B:BREA.0000025406.31193.e8","article-title":"Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen","volume":"85","author":"Johson","year":"2004","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jpba.2015.06.018_bib0070","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00280-004-0926-7","article-title":"Endoxifen (4-hdyroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen","volume":"55","author":"Lim","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0075","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1200\/JCO.2010.32.9839","article-title":"Dextromorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment","volume":"29","author":"De Graan","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0080","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jpba.2011.08.002","article-title":"Quantification of tamoxifen and three of its phase-I metabolites in human plasma by liquid chromatography\/triple-quadrupole mass spectrometry","volume":"56","author":"Binkhorst","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.06.018_bib0085","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/j.jchromb.2010.10.027","article-title":"An ultra performance liquid chromatography-tandem MS assay for tamoxifen metabolites profiling in plasma: first evidence of 4\u2032hydroxylated metabolites in breast cancer patients","volume":"878","author":"Dahmane","year":"2010","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2015.06.018_bib0090","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.jchromb.2011.04.011","article-title":"Development and validation of a quantitative assay for the determination of tamoxifen and its main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry","volume":"879","author":"Teunissen","year":"2011","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2015.06.018_bib0095","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jpba.2014.07.033","article-title":"An UPLC\u2013MS\/MS method for separation and accurate quantification of tamoxifen and its main metabolites isomers","volume":"100","author":"Arellano","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.06.018_bib0100","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1200\/JCO.2011.38.2572","article-title":"Determining the best dose for the individual patient","volume":"29","author":"Mathijssen","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0379-0738(93)90255-9","article-title":"Anatomy and physiology of hair","volume":"63","author":"Harkey","year":"1993","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.jpba.2015.06.018_bib0110","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1515\/CCLM.2004.247","article-title":"Hair analysis in toxicology","volume":"42","author":"Villain","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.jpba.2015.06.018_bib0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jpba.2013.08.050","article-title":"Validation of a method for the targeted analysis of 96 drugs in hair by UPLC\u2013MS\/MS","volume":"88","author":"Montesano","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.06.018_bib0120","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/cid\/cir131","article-title":"Atazanavir concentration in hair is the strongest predictor of ouctomes on antiretroviral therapy","volume":"52","author":"Gandhi","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jpba.2015.06.018_bib0125","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.steroids.2011.04.005","article-title":"Evaluation of a method to measure long term cortisol levels","volume":"76","author":"Manenschijn","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.jpba.2015.06.018_bib0130","doi-asserted-by":"crossref","first-page":"E1836","DOI":"10.1210\/jc.2012-1852","article-title":"A novel tool in the diagnosis and follow-up of (cyclic) cushing\u2019s syndrome: measurement of long-term cortisol in scalp hair","volume":"97","author":"Manenschijn","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jpba.2015.06.018_bib0135","unstructured":"www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM070107.pdf\/."},{"key":"10.1016\/j.jpba.2015.06.018_bib0140","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1081\/JLC-100101455","article-title":"Bioanalytical liquid chromatographic method validation. A review of current practices and procedures","volume":"23","author":"Rosing","year":"2000","journal-title":"J. Liquid Chromatogr. Relat. Technol."},{"key":"10.1016\/j.jpba.2015.06.018_bib0145","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.chroma.2005.01.004","article-title":"Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry","volume":"1082","author":"Gjerde","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2015.06.018_bib0150","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/jaoac\/89.4.1168","article-title":"Quantification of tamoxifen and metabolites and soy isoflavones in human plasma using liquid chromatography with electrospray ionization tandem mass spectrometry","volume":"89","author":"Williams","year":"2006","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.jpba.2015.06.018_bib0155","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/j.jchromb.2009.06.029","article-title":"Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry","volume":"877","author":"Teunissen","year":"2009","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2015.06.018_bib0160","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.aca.2010.10.009","article-title":"Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review","volume":"683","author":"Teunissen","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2015.06.018_bib0165","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/j.jchromb.2010.10.027","article-title":"An ultra performance liquid chromatography-tandem MS assay for tamoxifen metabolites profiling in plasma: first evidence of 4\u2032-hydroxylated metabolites in breast cancer patients","volume":"878","author":"Dahmane","year":"2010","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2015.06.018_bib0170","unstructured":"www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM070107.pdf \/."},{"key":"10.1016\/j.jpba.2015.06.018_bib0175","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/clinchem\/46.11.1846","article-title":"Stability of cannabinoids in hair samples exposed to sunlight","volume":"46","author":"Skopp","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jpba.2015.06.018_bib0180","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/dta.1607","article-title":"A study on photodegradation of methadone, EDDP, and other drugs of abuse in hair exposed to controlled UVB radiation","volume":"6","author":"Favretto","year":"2014","journal-title":"Drug Test Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515300340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515300340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T07:44:21Z","timestamp":1599119061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708515300340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":36,"alternative-id":["S0731708515300340"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2015.06.018","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of an UPLC\u2013MS\/MS method for the quantification of tamoxifen and its main metabolites in human scalp hair","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2015.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}