{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:25:22Z","timestamp":1783002322140,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jpba.2015.08.021","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T04:52:12Z","timestamp":1440478332000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["A chemometric optimization of method for determination of nitrosamines in gastric juices by GC\u2013MS"],"prefix":"10.1016","volume":"117","author":[{"given":"Mehmet","family":"Aky\u00fcz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eevket","family":"Ata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Din\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2015.08.021_bib0005","first-page":"321","article-title":"Formation and metabolism of N-nitrosamines","volume":"7","author":"Rostkowska","year":"1998","journal-title":"Pol. J. Environ. Stud."},{"key":"10.1016\/j.jpba.2015.08.021_bib0010","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.3748\/wjg.v12.i27.4296","article-title":"Nitrosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence","volume":"12","author":"Jakszyn","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jpba.2015.08.021_bib0015","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3945\/ajcn.111.012377","article-title":"K. T. Khaw N-nitroso compounds and cancer incidence: the European prospective investigation into cancer and nutrition (EPIC)\u2014Norfolk Study","volume":"93","author":"Loh","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jpba.2015.08.021_bib0020","unstructured":"Environmental Protection Agency Unregulated Contaminant Monitoring Rule. (2011) http:\/\/water.epa.gov\/lawsregs\/rulesregs\/sdwa\/ucmr\/ucmr2\/basicinformation.cfm."},{"key":"10.1016\/j.jpba.2015.08.021_bib0025","unstructured":"IARC Some N-nitroso compounds. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 17 (1987) Lyon, France."},{"key":"10.1016\/j.jpba.2015.08.021_bib0030","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF00525883","article-title":"Carcinogenicity of nitrosothiomorpholine and 1-nitrosopiperazine in rats","volume":"74","author":"Garcia","year":"1970","journal-title":"Zeitschrift f\u00fcr Krebsforschung"},{"key":"10.1016\/j.jpba.2015.08.021_bib0035","doi-asserted-by":"publisher","first-page":"7398","DOI":"10.1007\/s11356-013-1758-y","article-title":"Seasonal variations of particle-associated nitrosamines by gas chromatography-mass spectrometry in the atmospheric environment of Zonguldak, Turkey","volume":"20","author":"Aky\u00fcz","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jpba.2015.08.021_bib0040","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1136\/oem.57.3.180","article-title":"Exposure to high concentrations of nitrosamines and cancer mortality among a cohort of rubber workers","volume":"57","author":"Straif","year":"2000","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.jpba.2015.08.021_bib0045","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.chroma.2014.01.009","article-title":"Simultaneous determination of volatile and non-volatile nitrosamines in processed meat products by liquid chromatography tandem mass-spectrometry using atmospheric pressure chemical ionization and electrospray ionization","volume":"1330","author":"Herrmann","year":"2014","journal-title":"J. Chrom. A"},{"key":"10.1016\/j.jpba.2015.08.021_bib0050","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.aca.2011.06.024","article-title":"Determination of eight nitrosamines in water at the ng L\u22121 levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry","volume":"702","author":"Ripolles","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2015.08.021_bib0055","first-page":"283","article-title":"Volatile N-nitrosamines in mainstream cigarette smoke: occurrence and formation","volume":"70","author":"Tricker","year":"1992","journal-title":"Clin. Investig."},{"key":"10.1016\/j.jpba.2015.08.021_bib0060","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3390\/ma6020517","article-title":"A review of aspects of oxidative hair dye chemistry with special reference to N-nitrosamine formation","volume":"6","author":"Lewis","year":"2013","journal-title":"Materials"},{"key":"10.1016\/j.jpba.2015.08.021_bib0065","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0304-3835(97)00467-9","article-title":"Volatile N-nitrosamines in gastric juice of patients with various conditions of the gastrointestinal tract determined by gas chromatography\u2013mass spectrometry and related to intragastric pH and nitrate and nitrite levels","volume":"124","author":"Dallinga","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jpba.2015.08.021_bib0070","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S1383-5718(01)00331-X","article-title":"Mutagenic and clastogenic activity of gastric juice in human gastric diseases","volume":"514","author":"Hrelia","year":"2002","journal-title":"Mut. Res"},{"key":"10.1016\/j.jpba.2015.08.021_bib0075","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0278-6915(99)00017-4","article-title":"Exposure to N-nitroso compounds in a population of high liver cancer regions in thailand: volatile nitrosamine (VNA) levels in Thai food","volume":"37","author":"Mitacek","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jpba.2015.08.021_bib0080","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.foodchem.2012.07.002","article-title":"Determination of volatile nitrosamines in grilled lamb and vegetables using comprehensive gas chromatography-Nitrogen chemiluminescence detection","volume":"135","author":"Kocak","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2015.08.021_bib0085","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0731-7085(01)00509-X","article-title":"LC determination of dinitrosopiperazine in simulated gastric juice","volume":"26","author":"Walash","year":"2001","journal-title":"J. Pharmaceut. Biomed"},{"key":"10.1016\/j.jpba.2015.08.021_bib0090","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1023\/A:1016652213062","article-title":"Determination of volatile N-nitrosamines in food by high-performance liquid chromatography with fluorescence detection","volume":"56","author":"Komarova","year":"2001","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.jpba.2015.08.021_bib0095","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.chroma.2007.03.051","article-title":"Statistical designs and response surface techniques for the optimization of chromatographic systems","volume":"1158","author":"Ferreira","year":"2007","journal-title":"J. Chrom. A"},{"key":"10.1016\/j.jpba.2015.08.021_bib0100","series-title":"Comprehensive Chemometrics, Chemical and Biochemical Data Analysis, 3","author":"Brown","year":"2009"},{"key":"10.1016\/j.jpba.2015.08.021_bib0105","series-title":"Applied multivariate statistical analysis","author":"Johnson","year":"2002"},{"key":"10.1016\/j.jpba.2015.08.021_bib0110","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3758\/BRM.41.1.85","article-title":"A comparison of linear and mixture models for discriminant analysis under nonnormality","volume":"41","author":"Rausch","year":"2009","journal-title":"Behav Res. Methods"},{"key":"10.1016\/j.jpba.2015.08.021_bib0115","series-title":"Statistical design and analysis of experiments with applications to engineering and science","first-page":"728","author":"Mason","year":"2003"},{"key":"10.1016\/j.jpba.2015.08.021_bib0120","first-page":"322","article-title":"N-nitrosamines in gastric juice of subjects from high incidence area of esophageal cancer","volume":"10","author":"Yang","year":"1998","journal-title":"Chin. J. Oncol."},{"key":"10.1016\/j.jpba.2015.08.021_bib0125","unstructured":"HSDB, Hazardous Substances Data Bank. National Library of Medicine. http:\/\/toxnet.nlm.nih.gov\/cgi-bin\/sis\/htmlgen? HSDB and search on CAS number. (2009) Last accessed: 10\/7\/09."},{"key":"10.1016\/j.jpba.2015.08.021_bib0130","first-page":"2201","article-title":"The in vivo effect of N-Nitrosomorpholine on the activity of enzymes in rat blood serums and liver","volume":"15","author":"Maras","year":"2010","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.jpba.2015.08.021_bib0135","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/carcin\/24.2.291","article-title":"Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P450 2A3","volume":"24","author":"Wong","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jpba.2015.08.021_bib0140","first-page":"125","article-title":"Profile of telomerase and telomerase RNA expression in nasopharyngeal carcinogenesis of rats induced by N, N\u2032dinitrosopiperazine (DNP)","volume":"30","author":"Tang","year":"2001","journal-title":"Chin. J. Pathol."},{"key":"10.1016\/j.jpba.2015.08.021_bib0145","doi-asserted-by":"crossref","unstructured":"P. Morales, A. Haza, Use of a Human-Derived Liver Cell Line for the Detection of Protective Effect of Dietary Antioxidants against Food Mutagens, Hepatocellular Carcinoma - Basic Research, Dr. Joseph W.Y. Lau (Ed.), (2012) ISBN: 978-953-51-0023-2, InTech.","DOI":"10.5772\/27921"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515301205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515301205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T16:22:40Z","timestamp":1567095760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708515301205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":29,"alternative-id":["S0731708515301205"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2015.08.021","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A chemometric optimization of method for determination of nitrosamines in gastric juices by GC\u2013MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2015.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}