{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:20:31Z","timestamp":1790230831854,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jpba.2015.09.023","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T04:24:53Z","timestamp":1443241493000},"page":"405-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Preclinical pharmacokinetic evaluation of praziquantel loaded in poly (methyl methacrylate) nanoparticle using a HPLC\u2013MS\/MS"],"prefix":"10.1016","volume":"117","author":[{"given":"Mayara","family":"Malhado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline C.A.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel P.E.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heliana M.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Jorge G.F.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla V.V.","family":"Guilarducci-Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra L.","family":"Vi\u00e7osa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio","family":"Nele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds B.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos C.S.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Calil-Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2015.09.023_bib0005","author":"WHO","year":"2013","journal-title":"Schistosomiais"},{"key":"10.1016\/j.jpba.2015.09.023_bib0010","doi-asserted-by":"publisher","first-page":"e357","DOI":"10.1371\/journal.pntd.0000357","article-title":"Taste, a new incentive to switch to (R)-praziquantel in schistosomiasis treatment","volume":"3","author":"Meyer","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jpba.2015.09.023_bib0015","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/pola.23786","article-title":"From polymeric particles to multifunctional nanocapsules for biomedical applications using the miniemulsion process","volume":"48","author":"Landfester","year":"2010","journal-title":"J. Polym. Sci., Part A"},{"issue":"4","key":"10.1016\/j.jpba.2015.09.023_bib0020","first-page":"85","article-title":"Development of a brazilian nanoencapsulated drug for schistosomiasis treatment","volume":"1","author":"Fonseca","year":"2013","journal-title":"Vig. Sanit. Debate"},{"key":"10.1016\/j.jpba.2015.09.023_bib0025","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(00)00118-6","article-title":"Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future","volume":"47","author":"Muller","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"19","key":"10.1016\/j.jpba.2015.09.023_bib0030","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.2174\/138161209788682451","article-title":"Drug metabolism and pharmacokinetics in support of drug design","volume":"15","author":"Tang","year":"2009","journal-title":"Curr. Pharm. Des."},{"issue":"6","key":"10.1016\/j.jpba.2015.09.023_bib0035","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2165\/00003088-200342060-00002","article-title":"Metabolic stability for drug discovery and development. Pharmacokinetic and biochemical challenges","volume":"42","author":"Masimirembwa","year":"2003","journal-title":"Clin. Pharmacokinet."},{"issue":"2","key":"10.1016\/j.jpba.2015.09.023_bib0040","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0378-5173(00)00344-6","article-title":"Biopharmaceutics and pharmacokinetics in drug research","volume":"201","author":"Panghagnula","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2015.09.023_bib0045","author":"FDA","year":"2013","journal-title":"Guidance Ind. (Draft Guidance)"},{"key":"10.1016\/j.jpba.2015.09.023_bib0050","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jpba.2006.11.020","article-title":"Simultaneous determination of albendazole metabolites, praziquantel and its metabolite in plasma by high-performance liquid chromatography-electrospray mass spectrometry","volume":"44","author":"Bonato","year":"2007","journal-title":"J. Pharm. Biomed."},{"key":"10.1016\/j.jpba.2015.09.023_bib0055","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.jpba.2004.07.043","article-title":"A high-performance liquid chormatografic method for determination of praziquantel in plasma","volume":"36","author":"Hanpitakpong","year":"2014","journal-title":"J. Pharm. Biomed."},{"issue":"2","key":"10.1016\/j.jpba.2015.09.023_bib0060","first-page":"170","article-title":"A short review of some pharmacological, therapeutic and toxicological properties of praziquantel in man and animals","volume":"19","author":"Ali","year":"2006","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2015.09.023_bib0065","first-page":"2367","article-title":"Solid lipid nanoparticle suspension enhanced the therapeutic efficacy of praziquantel against tapeworm","volume":"6","author":"Xie","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpba.2015.09.023_bib0070","first-page":"86","article-title":"Enhancement the oral bioavailability of Praziquantel by incorporation into solid lipid nanoparticles","volume":"4","author":"Yang","year":"2009","journal-title":"Pharmazie"},{"key":"10.1016\/j.jpba.2015.09.023_bib0075","article-title":"Theoretical and computational investigations of nanoparticle-biomembrane interactions in cellular delivery","author":"Ding","year":"2014","journal-title":"Small"},{"key":"10.1016\/j.jpba.2015.09.023_bib0080","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.3762\/bjnano.5.248","article-title":"Nanoparticle interaction with live cell: quantitative fluorescence microscopy of nanoparticle size effects","volume":"5","author":"Shang","year":"2014","journal-title":"Beilstein J. Nanotechnol."},{"key":"10.1016\/j.jpba.2015.09.023_bib0085","first-page":"3255","article-title":"Engineered nanomaterial uptake and tissue distribuition: from cell to organism","volume":"8","author":"Kettiger","year":"2013","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.jpba.2015.09.023_bib0090","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S1773-2247(13)50055-4","article-title":"Mucosal drug delivery: barriers, in vitro models and formulation strategies","volume":"23","author":"Boegh","year":"2013","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2015.09.023_bib0095","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.jconrel.2013.05.043","article-title":"Can bioadhesive nanoparticle allow for more effective particle uptake from the small intestine?","volume":"170","author":"Reineke","year":"2013","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.jpba.2015.09.023_bib0100","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1002\/pat.1691","article-title":"Mechanical and thermal properties of attapulgite clay reinforced polymethylmethacrylate nanocomposites","volume":"22","author":"Chen","year":"2010","journal-title":"Polym. Adv. Technol."},{"issue":"7","key":"10.1016\/j.jpba.2015.09.023_bib0105","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1590\/S0074-02762011000700006","article-title":"Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni","volume":"106","author":"El-Lakkany","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.jpba.2015.09.023_bib0110","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1590\/S0100-879X2009000900007","article-title":"Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet","volume":"42","author":"Barros","year":"2009","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2","key":"10.1016\/j.jpba.2015.09.023_bib0115","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1645\/GE-1270.1","article-title":"Schistosoma haematobium (egyptian strain): rate of development and effect of praziquantel treatment","volume":"94","author":"Botros","year":"2008","journal-title":"J. Parasitol."},{"issue":"2","key":"10.1016\/j.jpba.2015.09.023_bib0120","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.bcp.2014.05.001","article-title":"Metabolic profiling of praziquantel enantiomers","volume":"90","author":"Wang","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jpba.2015.09.023_bib0125","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.actatropica.2010.08.020","article-title":"From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis","volume":"120","author":"Utzinger","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/j.jpba.2015.09.023_bib0130","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1016\/j.jchromb.2009.07.036","article-title":"Enantioselective analysis of praziquantel and trans-4-hydroxypraziquantel in human plasma by chiral LC\u2013MS\/MS: application to pharmacokinetics","volume":"877","author":"Lima","year":"2009","journal-title":"J. Chromatogr. B"},{"issue":"7","key":"10.1016\/j.jpba.2015.09.023_bib0135","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1124\/dmd.112.044925","article-title":"Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance","volume":"40","author":"Kadam","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2015.09.023_bib0140","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jconrel.2007.02.004","article-title":"PLGA nanoparticles for oral delivery of cyclosporine: Nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral\u00ae","volume":"119","author":"Italia","year":"2007","journal-title":"J. Control Release"},{"key":"10.1016\/j.jpba.2015.09.023_bib0145","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.2147\/IJN.S59338","article-title":"Preclinical studies of N3-O-toluyl-fluorouracil-loaded lipid-based nanosuspensions in H22\u2014bearing mice","volume":"9","author":"Zhang","year":"2014","journal-title":"Int. J. Nanomed."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515301643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515301643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T05:56:42Z","timestamp":1537336602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708515301643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":29,"alternative-id":["S0731708515301643"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2015.09.023","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical pharmacokinetic evaluation of praziquantel loaded in poly (methyl methacrylate) nanoparticle using a HPLC\u2013MS\/MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2015.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}