{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:20:08Z","timestamp":1790432408251,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Research Council"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jpba.2015.10.011","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T13:12:22Z","timestamp":1445778742000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Development and validation of an enantioselective LC\u2013MS\/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots"],"prefix":"10.1016","volume":"118","author":[{"given":"Isabel","family":"Meister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Leonidova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kova\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Duthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Huwyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2015.10.011_bib0005","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00228-003-0636-9","article-title":"Identification of human cytochrome P450s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data","volume":"59","author":"Li","year":"2003","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2015.10.011_bib0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-4347(97)00638-5","article-title":"Investigation of the stereoselective metabolism of praziquantel after incubation with rat liver microsomes by capillary electrophoresis and liquid chromatography-mass spectrometry","volume":"708","author":"Lerch","year":"1998","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.jpba.2015.10.011_bib0015","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0731-7085(01)00417-4","article-title":"Investigation of praziquantel metabolism in isolated rat hepatocytes","volume":"26","author":"Meier","year":"2001","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.10.011_bib0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molcata.2004.09.015","article-title":"Biomimetic oxidation of praziquantel catalysed by metalloporphyrins","volume":"226","author":"Melo","year":"2005","journal-title":"J. Mol. Catal."},{"key":"10.1016\/j.jpba.2015.10.011_bib0025","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1128\/AAC.44.10.2903-2904.2000","article-title":"Bioavailability of praziquantel increases with concomitant administration of food","volume":"44","author":"Castro","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jpba.2015.10.011_bib0030","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1590\/S0074-02762011000200016","article-title":"Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis","volume":"106","author":"Gotardo","year":"2011","journal-title":"Mem. I. Oswaldo Cruz"},{"key":"10.1016\/j.jpba.2015.10.011_bib0035","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1021\/ac8022839","article-title":"Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method","volume":"81","author":"Spooner","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2015.10.011_bib0040","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.4155\/bio.10.159","article-title":"Pharmacokinetic considerations as to when to use dried blood spot sampling","volume":"2","author":"Emmons","year":"2010","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2015.10.011_bib0045","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4155\/bio.12.321","article-title":"Merck\u2019s perspective on the implementation of dried blood spot technology in clinical drug development - why, when and how","volume":"5","author":"Xu","year":"2013","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2015.10.011_bib0050","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0731-7085(93)80095-I","article-title":"Liquid chromatographic separation of praziquantel enantiomers in serum using a cellulose-based chiral stationary phase","volume":"11","author":"Kelly","year":"1993","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.10.011_bib0055","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1016\/j.jchromb.2009.07.036","article-title":"Enantioselective analysis of praziquantel and trans-4-hydroxypraziquantel in human plasma by chiral LC\u2013-MS\/MS: application to pharmacokinetics","volume":"877","author":"Lima","year":"2009","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2015.10.011_bib0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-4347(96)00461-6","article-title":"High-performance liquid chromatography determination of praziquantel enantiomers in human serum using a reversed-phase cellulose-based chiral stationary phase and disc solid-phase extraction","volume":"692","author":"Liu","year":"1997","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.jpba.2015.10.011_bib0065","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0378-4347(97)00252-1","article-title":"Enantioselective analysis of praziquantel in plasma samples","volume":"696","author":"Polisel Jabor","year":"1997","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.jpba.2015.10.011_bib0070","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0378-4347(92)80425-P","article-title":"High-performance liquid chromatographic determination of the stereoselective biotransformation of the chiral drug praziquantel","volume":"578","author":"Westhoff","year":"1992","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2015.10.011_bib0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4155\/bio.14.298","article-title":"What is the right blood hematocrit preparation procedure for standards and quality control samples for dried blood spot analysis?","volume":"7","author":"Koster","year":"2015","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2015.10.011_bib0080","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration (FDA), Guidance for Industry, Bioanalytical Method Validation (2001), http:\/\/www.fda.gov (last accessed 23.4.2015)."},{"key":"10.1016\/j.jpba.2015.10.011_bib0085","unstructured":"Agilent, Bond Elut Dried Matrix Spotting. http:\/\/www.chem.agilent.com (last accessed 23.4.2015)."},{"key":"10.1016\/j.jpba.2015.10.011_bib0090","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.4155\/bio.13.171","article-title":"In-depth study of homogeneity in DBS using two different techniques: results from the EBF DBS-microsampling consortium","volume":"5","author":"Cobb","year":"2013","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2015.10.011_bib0095","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jpba.2006.11.020","article-title":"Simultaneous determination of albendazole metabolites, praziquantel and its metabolite in plasma by high-performance liquid chromatography-electrospray mass spectrometry","volume":"44","author":"Bonato","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.10.011_bib0100","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jpba.2004.07.043","article-title":"A high-performance liquid chromatographic method for determination of praziquantel in plasma","volume":"36","author":"Hanpitakpong","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.10.011_bib0105","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2125.2010.03874.x","article-title":"Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity","volume":"71","author":"Lima","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2015.10.011_bib0110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0731-7085(01)00605-7","article-title":"LC determination of praziquantel in human plasma","volume":"28","author":"Ridtitid","year":"2002","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515301849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515301849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T01:12:21Z","timestamp":1589591541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708515301849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":22,"alternative-id":["S0731708515301849"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2015.10.011","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of an enantioselective LC\u2013MS\/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2015.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}