{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:04:01Z","timestamp":1791047041076,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jpba.2015.11.027","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T01:52:37Z","timestamp":1449021157000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Pre-clinical investigation of the modulation of quetiapine plasma pharmacokinetics and tissues biodistribution by lipid-core nanocapsules"],"prefix":"10.1016","volume":"119","author":[{"given":"Fernando","family":"Carre\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Paese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Miranda","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia S.","family":"Guterres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Dalla Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2015.11.027_bib0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5507\/bp.2004.029","article-title":"Pharmacokinetics and biodistribution studies of Doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles synthesized by two different techniques","volume":"148","author":"Reddy","year":"2004","journal-title":"Biomed. Pap. Med. Fac. Univ. Palack\u00fd Olomouc Czechoslov."},{"key":"10.1016\/j.jpba.2015.11.027_bib0010","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nano.2011.05.013","article-title":"A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems","volume":"8","author":"Kaminskas","year":"2012","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.jpba.2015.11.027_bib0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.colsurfa.2010.12.011","article-title":"Formulation of lipid core nanocapsules","volume":"375","author":"Venturini","year":"2011","journal-title":"Colloids Surf. Physicochem. Eng. Aspects"},{"key":"10.1016\/j.jpba.2015.11.027_bib0020","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/mp300272a","article-title":"Enhanced brain delivery of the opioid peptide DAMGO in glutathione pegylated liposomes: a microdialysis study","volume":"10","author":"Lindqvist","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpba.2015.11.027_bib0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nano.2011.05.016","article-title":"Nanoparticle boon to drug delivery, therapeutics, diagnostics and imaging","volume":"8","author":"Parveen","year":"2012","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.jpba.2015.11.027_bib0030","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0169-409X(02)00228-4","article-title":"Biodegradable nanoparticles for drug and gene delivery to cells and tissue","volume":"55","author":"Panyam","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpba.2015.11.027_bib0035","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1166\/jbn.2009.1004","article-title":"Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area","volume":"5","author":"J\u00e4ger","year":"2009","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jpba.2015.11.027_bib0040","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0378-5173(89)90281-0","article-title":"Nanocapsule formation by interfacial polymer deposition following solvent displacement","volume":"55","author":"Fessi","year":"1989","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2015.11.027_bib0045","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1166\/jnn.2010.1920","article-title":"Nanocapsules prepared from amorphous polyesters: effect on the physicochemical characteristics, drug release, and photostability","volume":"10","author":"Fontana","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.jpba.2015.11.027_bib0050","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1039\/C2SM26959G","article-title":"An algorithm to determine the mechanism of drug distribution in lipid-core nanocapsule formulations","volume":"9","author":"Oliveira","year":"2012","journal-title":"Soft Matter"},{"key":"10.1016\/j.jpba.2015.11.027_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2009.09.001","article-title":"Biodegradable polymeric nanoparticles based drug delivery systems","volume":"75","author":"Kumari","year":"2010","journal-title":"Colloids Surf. B. Biointerfaces"},{"key":"10.1016\/j.jpba.2015.11.027_bib0060","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1080\/10826070802019681","article-title":"Stability-indicating HPLC method for the determination of quetiapine: application to tablets and human plasma","volume":"31","author":"Belal","year":"2008","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.jpba.2015.11.027_bib0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2125.2005.02507.x","article-title":"Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics","volume":"61","author":"Grimm","year":"2006","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2015.11.027_bib0070","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1124\/dmd.108.023291","article-title":"Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5","volume":"37","author":"Bakken","year":"2009","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"10.1016\/j.jpba.2015.11.027_bib0075","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jad.2008.12.016","article-title":"Efficacy, safety and tolerability of quetiapine augmentation in treatment resistant depression: an open-label, pilot study","volume":"117","author":"Anderson","year":"2009","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.jpba.2015.11.027_bib0080","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1166\/jbn.2014.1817","article-title":"Nanoencapsulation of olanzapine increases its efficacy in antipsychotic treatment and reduces adverse effects","volume":"10","author":"Dimer","year":"2014","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jpba.2015.11.027_bib0085","doi-asserted-by":"crossref","DOI":"10.5935\/0100-4042.20150137","article-title":"Acessing the mechanism of quetiapine distribution in lipid-core nanocapsules pseudo-phases using a validated LC\/UV method","author":"Carre\u00f1o","year":"2015","journal-title":"Qu\u00edm. Nova"},{"key":"10.1016\/j.jpba.2015.11.027_bib0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0731-7085(99)00036-9","article-title":"Analysis and pharmacokinetics of quetiapine and two metabolites in human plasma using reversed-phase HPLC with ultraviolet and electrochemical detection","volume":"20","author":"Davis","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.11.027_bib0095","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0731-7085(02)00395-3","article-title":"HPLC analysis of the novel antipsychotic drug quetiapine in human plasma","volume":"30","author":"Mandrioli","year":"2002","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.11.027_bib0100","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/bmc.2672","article-title":"Measurement of quetiapine and four quetiapine metabolites in human plasma by LC-MS\/MS","volume":"26","author":"Fisher","year":"2012","journal-title":"Biomed. Chromatogr. BMC"},{"key":"10.1016\/j.jpba.2015.11.027_bib0105","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/bmc.1012","article-title":"Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Quetiapine in plasma","volume":"22","author":"Ramakrishna Nirogi","year":"2008","journal-title":"Biomed. Chromatogr. BMC"},{"key":"10.1016\/j.jpba.2015.11.027_bib0110","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jpba.2007.03.034","article-title":"Validated HPLC-MS\/MS method for determination of quetiapine in human plasma","volume":"44","author":"Barrett","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.11.027_bib0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1570-0232(03)00592-0","article-title":"Fully automated on-line quantification of quetiapine in human serum by solid phase extraction and liquid chromatography","volume":"798","author":"Hasselstr\u00f8m","year":"2003","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"1","key":"10.1016\/j.jpba.2015.11.027_bib0120","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/FTD.0b013e3181c324c8","article-title":"A novel HPLC method for quantification of 10 antiepileptic drugs or metabolites in serum\/plasma using a monolithic column","volume":"32","author":"Heideloff","year":"2010","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.jpba.2015.11.027_bib0125","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jpba.2014.03.006","article-title":"Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD","volume":"95","author":"Zuluaga-Id\u00e1rraga","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.11.027_bib0130","unstructured":"International Conference on Harmonization (ICH); Technical Requirements for the Registration of Pharmaceutical for Human Use Validation of Analytical Procedures: Text and Methodology Q2 (R1), 2005."},{"key":"10.1016\/j.jpba.2015.11.027_bib0135","unstructured":"Food and Drug Administration (FDA); Guidance for Industry: Bioanalytical Method Validation, 2001."},{"key":"10.1016\/j.jpba.2015.11.027_bib0140","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1570-0232(02)00244-1","article-title":"Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods","volume":"774","author":"Almeida","year":"2002","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2015.11.027_bib0145","unstructured":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals [Internet]. 8th ed. Washington (DC): National Academies Press (US); 2011. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK54050\/ (accessed 08.07.13.)."},{"key":"10.1016\/j.jpba.2015.11.027_bib0150","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/1556-276X-9-233","article-title":"Labeling the oily core of nanocapsules and lipid-core nanocapsules with a triglyceride conjugated to a fluorescent dye as a strategy to particle tracking in biological studies","volume":"9","author":"Fiel","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.jpba.2015.11.027_bib0155","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijpharm.2006.01.035","article-title":"Diffusion and mathematical modeling of release profiles from nanocarriers","volume":"313","author":"Cruz","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2015.11.027_bib0160","first-page":"99","article-title":"Interactions between the cytochrome P450 system and the second-generation antipsychotics","volume":"28","author":"Prior","year":"2003","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jpba.2015.11.027_bib0165","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1166\/jbn.2015.2082","article-title":"Nanoencapsulation improves relative bioavailability and antipsychotic effect of olanzapine in rats","volume":"11","author":"Dimer","year":"2015","journal-title":"J. Biomed. Nanotechnol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515302454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515302454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T03:51:54Z","timestamp":1537156314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708515302454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":33,"alternative-id":["S0731708515302454"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2015.11.027","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-clinical investigation of the modulation of quetiapine plasma pharmacokinetics and tissues biodistribution by lipid-core nanocapsules","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2015.11.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}