{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:11:38Z","timestamp":1771042298075,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jpba.2015.11.043","type":"journal-article","created":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T19:31:28Z","timestamp":1448739088000},"page":"84-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS\/MS method"],"prefix":"10.1016","volume":"119","author":[{"given":"Anargyros","family":"Foivas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u0111elija","family":"Malenovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na\u0111a","family":"Kosti\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Bo\u017ei\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Kne\u017eevi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannis L.","family":"Loukas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-8286","authenticated-orcid":false,"given":"Yannis","family":"Dotsikas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2015.11.043_bib0005","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/S0039-6257(99)00110-1","article-title":"Dose\u2013response evaluation of the ocular hypotensive effect of brinzolamide ophthalmic suspension (Azopt). Brinzolamide Dose\u2013Response Study Group","volume":"44","author":"Silver","year":"2000","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.jpba.2015.11.043_bib0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0002-9394(99)00343-8","article-title":"The long-term safety and efficacy of brinzolamide 1.0% (azopt) in patients with primary open-angle glaucoma or ocular hypertension. The Brinzolamide Long-Term Therapy Study Group","volume":"129","author":"March","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.jpba.2015.11.043_bib0015","unstructured":"Australian Public Assessment Report for Brinzolamide\/Timolol Maleate. https.\/\/www.tga.gov.au\/auspar\/auspar-timolol-maleate-brinzolamide, (accessed 03.08.15)."},{"key":"10.1016\/j.jpba.2015.11.043_bib0020","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1124\/dmd.111.040055","article-title":"Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: implications for effects on ocular blood flow","volume":"39","author":"Kadam","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2015.11.043_bib0025","first-page":"47","article-title":"Brinzolamide","volume":"vol. 26","author":"Hall","year":"1999"},{"key":"10.1016\/j.jpba.2015.11.043_bib0030","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1021\/ac8022839","article-title":"Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method","volume":"81","author":"Spooner","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2015.11.043_bib0035","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jpba.2015.02.023","article-title":"Quantitation of pregabalin in dried blood spots and dried plasma spots by validated LC\u2013MS\/MS methods","volume":"109","author":"Kosti\u0107","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2015.11.043_bib0040","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s40262-014-0177-7","article-title":"Therapeutic drug monitoring by dried blood spot: progress to date and future directions","volume":"53","author":"Wilhelm","year":"2014","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jpba.2015.11.043_bib0045","article-title":"A novel dried blood spot-LCMS method for the quantification of methotrexate polyglutamates as a potential marker for methotrexate use in children","volume":"25","author":"Hawwa","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2015.11.043_bib0050","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.4155\/bio.10.103","article-title":"The effect of hematocrit on assay bias when using DBS samples for the quantitative bioanalysis of drugs","volume":"2","author":"Denniff","year":"2010","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2015.11.043_bib0055","unstructured":"Guideline on validation of bioanalytical methods. European Medicines Agency (2009). http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2011\/08\/WC500109686.pdf, (accessed 03.08.15)."},{"key":"10.1016\/j.jpba.2015.11.043_bib0060","unstructured":"Guidance for industry. Bioanalytical Method Validation (Draft guidance). FDA (2013). http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM368107.pdf, (accessed 03.08.15)."},{"key":"10.1016\/j.jpba.2015.11.043_bib0065","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1570-0232(02)00244-1","article-title":"Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods","volume":"774","author":"Almeida","year":"2002","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2015.11.043_bib0070","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1021\/acs.analchem.5b00908","article-title":"Investigation of different approaches to incorporating internal standard in DBS quantitative bioanalytical workflows and their effect on nullifying hematocrit-based assay bias","volume":"87","author":"Abu-Rabie","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2015.11.043_bib0075","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jchromb.2011.03.017","article-title":"Determination of moxifloxacin in dried blood spots using LC\u2013MS\/MS and the impact of the hematocrit and blood volume","volume":"879","author":"Vu","year":"2011","journal-title":"J. Chromatogr. B"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515302594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708515302594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T05:58:54Z","timestamp":1537163934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708515302594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":15,"alternative-id":["S0731708515302594"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2015.11.043","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS\/MS method","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2015.11.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}