{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:54:29Z","timestamp":1776376469158,"version":"3.51.2"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2014\/50410-3"],"award-info":[{"award-number":["2014\/50410-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2011\/51023-5"],"award-info":[{"award-number":["2011\/51023-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jpba.2016.01.045","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T07:10:05Z","timestamp":1453965005000},"page":"195-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Physicochemical characterization by AFM, FT-IR and DSC and biological assays of a promising antileishmania delivery system loaded with a natural Brazilian product"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-8953","authenticated-orcid":false,"given":"Franciane","family":"Marquele-Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina Cassia","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hernane da Silva","family":"Barud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Furlani","family":"Zoccal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Helena","family":"Faccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana I.","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andresa Aparecida","family":"Berretta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2016.01.045_bib0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0939-6411(00)00087-4","article-title":"Solid lipid nanoparticles (SLN) for controlled drug delivery\u2014a review of the state of the art","volume":"50","author":"M\u00fcller","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jpba.2016.01.045_bib0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.colsurfb.2012.05.006","article-title":"Preparation and stability study of norfloxacin-loaded solid lipid nanoparticle suspensions","volume":"98","author":"Wang","year":"2012","journal-title":"Colloids Surf. B."},{"key":"10.1016\/j.jpba.2016.01.045_bib0015","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.nantod.2011.08.002","article-title":"Emerging nanomaterials for targeting subcellular organelles","volume":"6","author":"Huang","year":"2011","journal-title":"Nano Today"},{"key":"10.1016\/j.jpba.2016.01.045_bib0020","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3109\/10717544.2011.577109","article-title":"Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanoparticles for oral delivery","volume":"18","author":"Dong","year":"2011","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jpba.2016.01.045_bib0025","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ejps.2012.12.005","article-title":"Preparation and characterization of lipid based nanosystems for topical delivery of quercetin","volume":"48","author":"Bose","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2016.01.045_bib0030","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1166\/jbn.2014.1834","article-title":"Effect of iontophoresis on topical delivery of doxorubicin-loaded solid lipid nanoparticles","volume":"10","author":"Taveira","year":"2014","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jpba.2016.01.045_bib0035","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.jpba.2010.06.007","article-title":"Development of nitrosyl ruthenium complex loaded lipid carriers for topical administration: improvement in skin stability and nitric oxide release by visible light irradiation","volume":"53","author":"Marquele-Oliveira","year":"2010","journal-title":"J. Pharm. Biom. Anal."},{"key":"10.1016\/j.jpba.2016.01.045_bib0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ijpharm.2013.12.006","article-title":"Development of protocol for screening the formulation components and the assessment of common quality problems of nano-structured lipid carriers","volume":"461","author":"Negi","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2016.01.045_bib0045","unstructured":"Leishmaniosis\u2014World Health Organization (WHO). <http:\/\/www.who.int\/leishmaniasis\/en\/>(accessed 04.02.2014)."},{"key":"10.1016\/j.jpba.2016.01.045_bib0050","first-page":"348","article-title":"Crude ethanolic extract, lignoids fraction and yangambin from Ocotea duckei (Lauraceae) show antileishmanial activity, Z. Naturforsch., C","volume":"62","author":"Monte-Neto","year":"2007","journal-title":"J. Biosci."},{"key":"10.1016\/j.jpba.2016.01.045_bib0055","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.exppara.2010.07.020","article-title":"Morphological and physiological changes in Leishmania promastigotes induced by yangambin a lignan obtained from Ocotea duckei","volume":"127","author":"Monte Neto","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jpba.2016.01.045_bib0060","first-page":"681","article-title":"Yangambin cytotoxicity: a pharmacologically active lignan obtained from Ocotea duckei Vattimo (Lauraceae). Z. Naturforsch","volume":"63","author":"Monte Neto","year":"2008","journal-title":"C: J. Biosci."},{"key":"10.1016\/j.jpba.2016.01.045_bib0065","first-page":"877","article-title":"Novel targeting using nanoparticles: an approach to the development of an effective antileishmanial drug delivery system","volume":"9","author":"Ribeiro","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpba.2016.01.045_bib0070","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ijpharm.2012.03.032","article-title":"Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway","volume":"430","author":"Martins","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2016.01.045_bib0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/2211738502666140804233740","article-title":"Challenges in developing a safe nanomedicine based on Ocotea duckei Vattimo to leishmaniasis treatment: methodology, nanoparticle development and cytotoxicity assays","volume":"2","author":"Rossetti","year":"2014","journal-title":"Pharm. Nanotechnol."},{"key":"10.1016\/j.jpba.2016.01.045_bib0080","doi-asserted-by":"crossref","first-page":"e15263","DOI":"10.1371\/journal.pone.0015263","article-title":"A method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells","volume":"5","author":"Marim","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2016.01.045_bib0085","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1073\/pnas.1211521110","article-title":"Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila","volume":"110","author":"Case","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpba.2016.01.045_bib0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jpba.2016.01.045_bib0095","doi-asserted-by":"crossref","first-page":"e2847","DOI":"10.1371\/journal.pntd.0002847","article-title":"In vitro and in vivo trypanocidal activity of H2bdtc-loaded solid lipid nanoparticles","volume":"8","author":"Carneiro","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.jpba.2016.01.045_bib0100","first-page":"393","article-title":"Solid lipid nanoparticles (SLN) and nanoestructured lipid carriers (NLC)\u2014structural investigations on two different carriers systems","volume":"15","author":"Saupe","year":"2005","journal-title":"Bio-Med. Mater. Eng."},{"key":"10.1016\/j.jpba.2016.01.045_bib0105","first-page":"1693","article-title":"Preparation and characterization of solid lipid nanoparticles through rapid expansion of supercritical solution","volume":"5","author":"Akbari","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.jpba.2016.01.045_bib0110","first-page":"133","article-title":"Isolation of soy lecithin from soy sludge, its standardization and behavioural study","volume":"6","author":"Choudhary","year":"2013","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.jpba.2016.01.045_bib0115","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1080\/03639040802130061","article-title":"Lipid nanoparticles with a solid matrix (SLN\u00ae, NLC\u00ae LDC\u00ae) for oral drug delivery","volume":"34","author":"Muchow","year":"2008","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jpba.2016.01.045_bib0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejpb.2011.02.012","article-title":"Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release","volume":"79","author":"Souza","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jpba.2016.01.045_bib0125","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.colsurfb.2013.08.009","article-title":"Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity","volume":"112","author":"How","year":"2013","journal-title":"Colloids Surf. B."},{"key":"10.1016\/j.jpba.2016.01.045_bib0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jfoodeng.2013.11.027","article-title":"Encapsulation of eugenol rich clove extract in solid lipid carriers","volume":"127","author":"Cort\u00e9s-Rojas","year":"2014","journal-title":"J. Food Eng."},{"key":"10.1016\/j.jpba.2016.01.045_bib0135","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jconrel.2008.10.002","article-title":"Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles","volume":"133","author":"Li","year":"2009","journal-title":"J. Control Release"},{"key":"10.1016\/j.jpba.2016.01.045_bib0140","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jps.2600510825","article-title":"Analysis of data on the medicament release from ointments","volume":"51","author":"Higuchi","year":"1952","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2016.01.045_bib0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0966-842X(00)01936-3","article-title":"Pro-inflammatory programmed cell death","volume":"9","author":"Cookson","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jpba.2016.01.045_bib0150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejps.2013.04.013","article-title":"Intracellular trafficking of solid lipid nanoparticles and their distribution between cells through tunneling nanotubes","volume":"50","author":"Kristl","year":"2013","journal-title":"Eur. J. Pharm. Sci."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516300450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516300450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T18:56:44Z","timestamp":1537037804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708516300450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":30,"alternative-id":["S0731708516300450"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2016.01.045","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physicochemical characterization by AFM, FT-IR and DSC and biological assays of a promising antileishmania delivery system loaded with a natural Brazilian product","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2016.01.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}