{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:21:56Z","timestamp":1790684516185,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"University of Bologna and Aarhus University Hospital"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jpba.2016.01.048","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T13:30:50Z","timestamp":1453728650000},"page":"141-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Mass spectrometry characterization of circulating human serum albumin microheterogeneity in patients with alcoholic hepatitis"],"prefix":"10.1016","volume":"122","author":[{"given":"Marina","family":"Naldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Baldassarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Domenicali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando Antonino","family":"Giannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Montomoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Damgaard","family":"Sandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Glavind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Vilstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Caraceni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-9172","authenticated-orcid":false,"given":"Carlo","family":"Bertucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2016.01.048_bib0005","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.20720","article-title":"Albumin: biochemical properties and therapeutic potential","volume":"41","author":"Quinlan","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2016.01.048_bib0010","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ejim.2013.05.015","article-title":"Clinical indications for the albumin use: still a controversial issue","volume":"24","author":"Caraceni","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.jpba.2016.01.048_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jceh.2014.08.007","article-title":"Role of human albumin in the management of complications of liver cirrhosis","author":"Bernardi","year":"2014","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.jpba.2016.01.048_bib0020","doi-asserted-by":"crossref","first-page":"e85216","DOI":"10.1371\/journal.pone.0085216","article-title":"Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases","volume":"9","author":"Nagumo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2016.01.048_bib0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.mam.2011.12.002","article-title":"Human serum albumin: from bench to bedside","volume":"33","author":"Fanali","year":"2012","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jpba.2016.01.048_bib0030","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.27322","article-title":"Post-transcriptional changes of serum albumin: clinical and prognostic significance in hospitalized patients with cirrhosis","volume":"3","author":"Domenicali","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2016.01.048_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/liv.12860","article-title":"Ischemia-modified albumin: a marker of bacterial infection in hospitalized patients with cirrhosis","author":"Giannone","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.jpba.2016.01.048_bib0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0029-1214370","article-title":"Oxidative stress and alcoholic liver disease","volume":"29","author":"Wu","year":"2009","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.jpba.2016.01.048_bib0045","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jpba.2016.01.048_bib0050","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1002\/rcm.2154","article-title":"Characterization of cysteinylation of pharmaceutical-grade human serum albumin by electrospray ionization mass spectrometry and low-energy collision-induced dissociation tandem mass spectrometry","volume":"19","author":"Kleinova","year":"2005","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.01.048_bib0055","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1097\/01.CCM.0000169876.14858.91","article-title":"Heterogeneity and oxidation status of commercial human albumin preparations in clinical use","volume":"33","author":"Bar-Or","year":"2005","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jpba.2016.01.048_bib0060","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1255\/ejms.1256","article-title":"A fast and validated mass spectrometry method for the evaluation of human serum albumin structural modifications in the clinical field","volume":"19","author":"Naldi","year":"2013","journal-title":"Eur. J. Mass Spectrom. (Chichester, Engl.)"},{"key":"10.1016\/j.jpba.2016.01.048_bib0065","doi-asserted-by":"crossref","first-page":"e8971","DOI":"10.1371\/journal.pone.0008971","article-title":"Protein antioxidant response to the stress and the relationship between molecular structure and antioxidant function","volume":"5","author":"Medina-Navarro","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2016.01.048_bib0070","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jchromb.2013.02.004","article-title":"Fast separation of large biomolecules using short monolithic columns","volume":"927","author":"Podgornik","year":"2013","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2016.01.048_bib0075","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.aca.2013.09.023","article-title":"Capillary zone electrophoresis and capillary electrophoresis-mass spectrometry for analyzing qualitative and quantitative variations in therapeutic albumin","volume":"800","author":"Marie","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2016.01.048_bib0080","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.febslet.2008.04.057","article-title":"The antioxidant properties of serum albumin","volume":"582","author":"Roche","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jpba.2016.01.048_bib0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/10715760400024935","article-title":"Differential effects of cysteine and methionine residues in the antioxidant activity of human serum albumin","volume":"39","author":"Bourdon","year":"2005","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.jpba.2016.01.048_bib0090","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0047-6374(98)00152-3","article-title":"Methionine residues may protect proteins from critical oxidative damage","volume":"107","author":"Levine","year":"1999","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.jpba.2016.01.048_bib0095","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1073\/pnas.93.26.15036","article-title":"Methionine residues as endogenous antioxidants in proteins","volume":"93","author":"Levine","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpba.2016.01.048_bib0100","first-page":"1","article-title":"Mass spectrometric characterization of human serum albumin dimer: a new potential biomarker in chronic liver diseases","author":"Naldi","year":"2014","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516300486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516300486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T20:21:32Z","timestamp":1537042892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708516300486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":20,"alternative-id":["S0731708516300486"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2016.01.048","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mass spectrometry characterization of circulating human serum albumin microheterogeneity in patients with alcoholic hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2016.01.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}