{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:41:16Z","timestamp":1783165276439,"version":"3.54.6"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Direcci\u00f3n General de Tr\u00e1fico (Spanish Ministry of Interior)","award":["SPIP2015-01838"],"award-info":[{"award-number":["SPIP2015-01838"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["AGL-2014-53647-R"],"award-info":[{"award-number":["AGL-2014-53647-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jpba.2016.02.041","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T17:43:03Z","timestamp":1456681383000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Optimization of ultrasound assisted dispersive liquid-liquid microextraction of six antidepressants in human plasma using experimental design"],"prefix":"10.1016","volume":"124","author":[{"given":"P.","family":"Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Taboada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Regenjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Carro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2016.02.041_bib0005","series-title":"Health Care Activities","first-page":"101","article-title":"Health at a glance 2013: OECD Indicators","author":"The Organisation for Economic Co-operation and Development (OECD)","year":"2013"},{"key":"10.1016\/j.jpba.2016.02.041_bib0010","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.eurpsy.2007.11.001","article-title":"Prescribing patterns of antidepressants in europe: results from the factors influencing depression endpoints research (FINDER) study","volume":"23","author":"Bauer","year":"2008","journal-title":"Eur. Psychol."},{"key":"10.1016\/j.jpba.2016.02.041_bib0015","unstructured":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios (Web), Enero 2015, Informe de utilizaci\u00f3n de medicamentos antidepresivos en Espa\u00f1a durante el periodo, 2000\u20132013, Ref. U\/AD\/V1\/14012015, Available in: http:\/\/www.aemps.gob.es\/medicamentosUsoHumano\/observatorio\/docs\/antidepresivos-2000-2013.pdf."},{"key":"10.1016\/j.jpba.2016.02.041_bib0020","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.talanta.2004.12.025","article-title":"Determination of fluoxetine and its N-desmethyl metabolite in human plasma by high-performance liquid chromatography","volume":"66","author":"Vlase","year":"2005","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2016.02.041_bib0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jchromb.2006.06.001","article-title":"Simultaneous determination of fluvoxamine isomers and quetiapine in human plasma by means of high-performance liquid chromatography","volume":"843","author":"Saracino","year":"2006","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2016.02.041_bib0030","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jpba.2009.07.015","article-title":"2 Development of a stir bar sorptive extraction based HPLC-FLD method for the quantification of serotonin reuptake inhibitors in plasma, urine and brain tissue samples","volume":"51","author":"Unceta","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.02.041_bib0035","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijpharm.2015.08.001","article-title":"Polypyrrole\/magnetic nanoparticles composite as an efficient sorbent for dispersive micro-solid-phase extraction of antidepressant drugs from biological fluids","volume":"494","author":"Asgharinezhad","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2016.02.041_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2006.03.007","article-title":"Determination of organic compounds in water using dispersive liquid\u2013liquid microextraction","volume":"1116","author":"Rezaee","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.02.041_bib0045","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.chroma.2009.11.088","article-title":"Evolution of dispersive liquid\u2013liquid microextraction method","volume":"1217","author":"Rezaee","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.02.041_bib0050","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.aca.2013.01.016","article-title":"A rapid ultrasound-assisted dispersive liquid\u2013liquid microextraction followed by ultra-performance liquid chromatography for the simultaneous determination of seven benzodiazepines in human plasma samples","volume":"767","author":"Fern\u00e1ndez","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2016.02.041_bib0055","doi-asserted-by":"crossref","first-page":"8239","DOI":"10.1039\/C4AY01348D","article-title":"Optimization of ultrasound-assisted dispersive liquid\u2013liquid microextraction for ultra performance liquid chromatography determination of benzodiazepines in urine and hospital wastewater","volume":"6","author":"Fern\u00e1ndez","year":"2014","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jpba.2016.02.041_bib0060","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jat.3035","article-title":"Analysis of drugs of abuse in human plasma by dispersive liquid\u2013liquid microextraction and high-performance liquid chromatography","volume":"35","author":"Fernandez","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jpba.2016.02.041_bib0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.microc.2015.05.009","volume":"123","author":"Fisichella","year":"2015","journal-title":"Microchem. J."},{"key":"10.1016\/j.jpba.2016.02.041_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chroma.2015.11.087","article-title":"Tandem dispersive liquid\u2013liquid microextraction as an efficient method for determination of basic drugs in complicated matrices","volume":"1429","author":"Bazregar","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.02.041_bib0075","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/bmc.3396","article-title":"Determination of three antidepressants in urine using simultaneous derivatization and temperature-assisted dispersive liquid\u2013liquid microextraction followed by gas chromatography\u2013flame ionization detection","volume":"29","author":"Akbar","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2016.02.041_bib0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11419-012-0152-7","article-title":"Simultaneous determination of new-generation antidepressants in plasma by gas chromatography\u2013mass spectrometry","volume":"31","author":"Pietracci","year":"2013","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.jpba.2016.02.041_bib0085","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jchromb.2008.12.070","article-title":"Solid-phase microextraction using poly(pyrrole) Film and liquid chromatography with UV detection for analysis of antidepressants in plasma samples","volume":"877","author":"Rodrigues Chaves","year":"2009","journal-title":"J. Chromatogr B"},{"key":"10.1016\/j.jpba.2016.02.041_bib0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.chroma.2011.11.055","article-title":"Three-phase hollow fiber microextraction based on two inmiscible organic solvents for determination of tricyclic antidepressant drugs: comparison with conventional three-phase hollow fiber microextraction","volume":"1222","author":"Ghambarian","year":"2012","journal-title":"J. Chromatogr A"},{"key":"10.1016\/j.jpba.2016.02.041_bib0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jchromb.2005.03.006","article-title":"Simultaneous determination of fluoxetine citalopram, paroxetine, venlafaxine in plasma by high performance liquid chromatography- electrospray ionization mass spectrometry (HPLC-MS\/ESI)","volume":"820","author":"He","year":"2005","journal-title":"J. Chromatogr B"},{"key":"10.1016\/j.jpba.2016.02.041_bib0100","doi-asserted-by":"crossref","first-page":"650","DOI":"10.2471\/BLT.08.050955","article-title":"The declaration of helsinki and public health","volume":"86","author":"Williams","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jpba.2016.02.041_bib0105","series-title":"Pharmaceutical Experimental Design","author":"Lewis","year":"1999"},{"key":"10.1016\/j.jpba.2016.02.041_bib0110","unstructured":"D. Mathieu, J. Nony, R. Phan-Tan-Luu, NemrodW\u00ae, Version 2011, LPRAI, Marseille."},{"key":"10.1016\/j.jpba.2016.02.041_bib0115","unstructured":"Food and Drug administration (FDA), U.S Department of Health and Human Services, Guidance for Industry, Bioanalytical Method Validation 2001, http:\/\/www.fda.gov\/downloads\/Drugs\/...\/Guidances\/ucm070107.pdf."},{"key":"10.1016\/j.jpba.2016.02.041_bib0120","unstructured":"International Conference on Harmonization, 2005, Validation of analytical procedures: Methodology ICH Q2 (R1), Available in: http:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Quality\/Q2_R1\/Step4\/Q2_R1__Guideline.pdf."},{"key":"10.1016\/j.jpba.2016.02.041_bib0125","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-4347(01)00305-X","article-title":"High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum","volume":"761","author":"Tournel","year":"2001","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2016.02.041_bib0130","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jpba.2004.06.008","article-title":"A rapid HPLC-DAD method of analysis of fluoxetine and norfluoxetine in plasma from overdose patients","volume":"36","author":"Sabbioni","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.02.041_bib0135","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jpba.2007.11.048","article-title":"Simultaneous determination of citalopram, fluoxetine and their main metabolites in human urine samples by solid-phase microextraction coupled with high-performance liquid chromatography","volume":"46","author":"Unceta","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.02.041_bib0140","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1016\/j.chroma.2010.10.002","article-title":"In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma","volume":"1217","author":"Zheng","year":"2010","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516301042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516301042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T20:22:16Z","timestamp":1536956536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708516301042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":28,"alternative-id":["S0731708516301042"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2016.02.041","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of ultrasound assisted dispersive liquid-liquid microextraction of six antidepressants in human plasma using experimental design","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2016.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}