{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:46:43Z","timestamp":1772952403521,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Leading National Research Center","award":["31\/KNOW\/2013"],"award-info":[{"award-number":["31\/KNOW\/2013"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jpba.2016.08.024","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T01:51:46Z","timestamp":1472867506000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Serum metabolic fingerprinting after exposure of rats to quinolinic acid"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-4429","authenticated-orcid":false,"given":"Bartlomiej","family":"Kalaska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Ciborowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Domaniewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Czyzewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Godzien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Miltyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Kretowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2016.08.024_bib0005","first-page":"1116","article-title":"Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation","volume":"20","author":"Wang","year":"2014","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jpba.2016.08.024_bib0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0167-5699(99)01520-0","article-title":"Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?","volume":"20","author":"Mellor","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jpba.2016.08.024_bib0015","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/ndt\/gfn739","article-title":"Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms","volume":"24","author":"Schefold","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jpba.2016.08.024_bib0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0306-4522(92)90467-G","article-title":"Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse","volume":"51","author":"Saito","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpba.2016.08.024_bib0025","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.humimm.2012.09.009","article-title":"Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis","volume":"74","author":"Lahdou","year":"2013","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000085525","article-title":"Inflammation in end-stage renal disease\u2014a fire that burns within","volume":"149","author":"Stenvinkel","year":"2005","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0035","doi-asserted-by":"crossref","first-page":"F565","DOI":"10.1152\/ajprenal.2000.279.3.F565","article-title":"Mechanism of increases in l-kynurenine and quinolinic acid in renal insufficiency","volume":"279","author":"Saito","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0040","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the ARRIVE guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0045","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nut.2005.04.002","article-title":"Comparing rat\u2019s to human\u2019s age: how old is my rat in people years","volume":"21","author":"Quinn","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.jpba.2016.08.024_bib0050","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1021\/pr3008946","article-title":"Combination of LC\u2013MS- and GC\u2013MS-based metabolomics to study the effect of ozonated autohemotherapy on human blood","volume":"11","author":"Ciborowski","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2016.08.024_bib0055","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nprot.2011.335","article-title":"Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry","volume":"6","author":"Dunn","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jpba.2016.08.024_bib0060","doi-asserted-by":"crossref","first-page":"e31982","DOI":"10.1371\/journal.pone.0031982","article-title":"Metabolomics with LC-QTOF-MS permits the prediction of disease stage in aortic abdominal aneurysm based on plasma metabolic fingerprint","volume":"7","author":"Ciborowski","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2016.08.024_bib0065","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1021\/acs.jproteome.5b00169","article-title":"Rapid and reliable identification of phospholipids for untargeted metabolomics with LC-ESI-QTOF-MS\/MS","volume":"14","author":"Godzien","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2016.08.024_bib0070","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3923\/pjbs.2009.1025.1030","article-title":"New evidence on hypoglycemic effect of quinolinic acid in diabetic rats","volume":"12","author":"Dayer","year":"2009","journal-title":"Pak. J. Biol. Sci."},{"key":"10.1016\/j.jpba.2016.08.024_bib0075","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF01010286","article-title":"Enhancement of tyrosine transaminase activity by quinolinic acid","volume":"57","author":"Hardeland","year":"1970","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.jpba.2016.08.024_bib0080","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/PL00000852","article-title":"Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications","volume":"58","author":"Thomas","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jpba.2016.08.024_bib0085","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00726-006-0264-7","article-title":"Polyamines in renal failure","volume":"31","author":"Igarashi","year":"2006","journal-title":"Amino Acids"},{"key":"10.1016\/j.jpba.2016.08.024_bib0090","first-page":"S234","article-title":"Serum levels of polyamines in patients with chronic renal failure","volume":"16","author":"Saito","year":"1983","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.jpba.2016.08.024_bib0095","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1093\/ndt\/gft217","article-title":"Metabolites associate with kidney function decline and incident chronic kidney disease in the general population","volume":"28","author":"Goek","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jpba.2016.08.024_bib0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12640-015-9535-y","article-title":"Protective effect of spermidine against excitotoxic neuronal death induced by quinolinic acid in rats: possible neurotransmitters and neuroinflammatory mechanism","volume":"28","author":"Jamwal","year":"2015","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jpba.2016.08.024_bib0105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1124\/mol.104.006353","article-title":"The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide","volume":"67","author":"Lo Verme","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0110","first-page":"1367","article-title":"A serum metabonomic study on the difference between alcohol-and HBV-induced liver cirrhosis by ultraperformance liquid chromatography coupled to mass spectrometry plus quadrupole time-of-flight mass spectrometry","volume":"124","author":"Lian","year":"2011","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jpba.2016.08.024_bib0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jpba.2014.05.023","article-title":"Metabolomic study of lipids in serum for biomarker discovery in Alzheimer\u2019s disease using direct infusion mass spectrometry","volume":"98","author":"Gonzalez-Dominguez","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.08.024_bib0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4615-0135-0_19","article-title":"Quinolinic acid in the pathogenesis of Alzheimer\u2019s disease","volume":"527","author":"Guillemin","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0125","first-page":"11347","article-title":"Diabetes alters the blood glucose response to ketamine in streptozotocin-diabetic rats","volume":"8","author":"Chen","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.jpba.2016.08.024_bib0130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/0-306-46818-2_38","article-title":"Rapid diagnosis of organic acidemias and fatty-acid oxidation defects by quantitative electrospray tandem-MS acyl-carnitine analysis in plasma","volume":"466","author":"Vreken","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0135","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tips.2012.02.004","article-title":"Prostaglandins and chronic inflammation","volume":"33","author":"Aoki","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jpba.2016.08.024_bib0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-1-4615-4709-9_46","article-title":"Changes in membrane fluidity induced by tryptophan and its metabolites","volume":"467","author":"Rudzite","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jpba.2016.08.024_bib0145","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cca.2014.06.010","article-title":"Development of a liquid chromatography\u2013mass spectrometry method for the determination of the neurotoxic quinolinic acid in human serum","volume":"436","author":"Meinitzer","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jpba.2016.08.024_bib0150","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1365\/s10337-007-0241-7","article-title":"CZE determination of quinolinic acid in rat brain tissue and plasma","volume":"65","author":"Tenorio-Lopez","year":"2007","journal-title":"Chromatographia"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516304691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516304691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T01:39:34Z","timestamp":1568338774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708516304691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":30,"alternative-id":["S0731708516304691"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2016.08.024","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum metabolic fingerprinting after exposure of rats to quinolinic acid","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2016.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}