{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:21:24Z","timestamp":1780449684582,"version":"3.54.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Federal Ministry of the Interior of the Federal Republic of Germany"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jpba.2016.09.015","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T18:51:42Z","timestamp":1474051902000},"page":"482-496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution\/high accuracy mass spectrometry"],"prefix":"10.1016","volume":"131","author":[{"given":"Christian","family":"G\u00f6rgens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Guddat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Wachsmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Katrin","family":"Orlovius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Sigmund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Thevis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Sch\u00e4nzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2016.09.015_bib0005","series-title":"The 2016 Prohibited List International Standard","author":"World Anti-Doping Agency","year":"2016"},{"key":"10.1016\/j.jpba.2016.09.015_bib0010","unstructured":"WADA Technical Document \u2013 TD2015MRPL. https:\/\/wada-main-prod.s3.amazonaws.com\/resources\/files\/wada_td2015mrpl_minimum_required_perf_levels_en.pdf (2015) (accessed 12.05.16)."},{"key":"10.1016\/j.jpba.2016.09.015_bib0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-61779-934-1_10","article-title":"Detection of prohibited substances by liquid chromatography tandem mass spectrometry for sports doping control","volume":"902","author":"Ahrens","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jpba.2016.09.015_bib0020","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1016\/j.chroma.2009.06.003","article-title":"Qualitative detection of diuretics and acidic metabolites of other doping agents in human urine by high-performance liquid chromatography\u2013tandem mass spectrometry: comparison between liquid\u2013liquid extraction and direct injection","volume":"1216","author":"Deventer","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0025","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/dta.372","article-title":"High-throughput screening for various classes of doping agents using a new \u2018dilute-and-shoot\u2019 liquid chromatography-tandem mass spectrometry multi-target approach","volume":"3","author":"Guddat","year":"2011","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0030","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/anatox\/35.9.665","article-title":"Liquid chromatography-tandem mass spectrometry screening method for the simultaneous detection of stimulants and diuretics in urine","volume":"35","author":"Hsu","year":"2011","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jpba.2016.09.015_bib0035","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1016\/j.chroma.2011.09.020","article-title":"Screening and confirmation analysis of stimulants, narcotics and beta-adrenergic agents in human urine by hydrophilic interaction liquid chromatography coupled to mass spectrometry","volume":"1218","author":"Mazzarino","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0040","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/jms.1436","article-title":"A high-throughput multicomponent screening method for diuretics masking agents, central nervous system (CNS) stimulants and opiates in human urine by UPLC-MS\/MS","volume":"43","author":"Th\u00f6rngren","year":"2008","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0045","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1016\/j.chroma.2009.03.033","article-title":"Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry I. Screening analysis","volume":"1216","author":"Badoud","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0050","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/rcm.4554","article-title":"Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography\/high-resolution time-of-flight mass spectrometry","volume":"24","author":"Vonaparti","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0055","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/dta.50","article-title":"Generic sample preparation and dual polarity liquid chromatography-time-of-flight mass spectrometry for high-throughput screening in doping analysis","volume":"1","author":"Kolmonen","year":"2009","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.aca.2012.02.002","article-title":"Development and validation of an open screening method for diuretics, stimulants and selected compounds in human urine by UHPLC-HRMS for doping control","volume":"721","author":"Giron","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2016.09.015_bib0065","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.chroma.2013.03.006","article-title":"Use of ultra-high pressure liquid chromatography coupled to high resolution mass spectrometry for fast screening in high throughput doping control","volume":"1288","author":"Musenga","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/dta.1650","article-title":"Urinary detection of conjugated and unconjugated anabolic steroids by dilute-and-shoot liquid chromatography-high resolution mass spectrometry","volume":"7","author":"Tudela","year":"2015","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0075","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.chroma.2013.03.006","article-title":"Use of ultra-high pressure liquid chromatography coupled to high resolution mass spectrometry for fast screening in high throughput doping control","volume":"1288","author":"Musenga","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chroma.2013.01.001","article-title":"Sensitive detection of 3\u2032-hydroxy-stanozolol glucuronide by liquid chromatography-tandem mass spectrometry","volume":"1292","author":"Tudela","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0085","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/dta.1516","article-title":"Expanding analytical possibilities concerning the detection of stanozolol misuse by means of high resolution\/high accuracy mass spectrometric detection of stanozolol glucuronides in human sports drug testing","volume":"5","author":"Sch\u00e4nzer","year":"2013","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0090","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.steroids.2013.09.005","article-title":"A new sulphate metabolite as a long-term marker of metandienone misuse","volume":"78","author":"Gomez","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.jpba.2016.09.015_bib0095","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jsbmb.2012.05.010","article-title":"New potential markers for the detection of boldenone misuse","volume":"132","author":"Gomez","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jpba.2016.09.015_bib0100","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.steroids.2012.10.008","article-title":"Alternative long-term markers for the detection of methyltestosterone misuse","volume":"78","author":"Gomez","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.jpba.2016.09.015_bib0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jms.3508","article-title":"New potential biomarkers for mesterolone misuse in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry","volume":"50","author":"Lu","year":"2015","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0110","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jms.3517","article-title":"New clostebol metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry and their application for doping control","volume":"50","author":"Lu","year":"2015","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0115","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/dta.1895","article-title":"Analysis of anabolic androgenic steroids as sulfate conjugates using high performance liquid chromatography coupled to tandem mass spectrometry","volume":"7","author":"Rzeppa","year":"2015","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0120","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jssc.201501060","article-title":"Simplifying and expanding the screening for peptides<2kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry","volume":"39","author":"Thomas","year":"2016","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2016.09.015_bib0125","series-title":"Recent Advances in Doping Analysis (15)","first-page":"97","article-title":"Sulfoconjugates of heavy volatile nitrogen containing doping substances for improved LC-MS\/MS screening","author":"Orlovius","year":"2007"},{"key":"10.1016\/j.jpba.2016.09.015_bib0130","doi-asserted-by":"crossref","first-page":"9477","DOI":"10.1007\/s00216-013-7383-2","article-title":"In vitro synthesis and characterisation of three fenoterol sulfoconjugates detected in fenoterol post-administration urine samples","volume":"405","author":"Orlovius","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2016.09.015_bib0135","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/dta.84","article-title":"Terbutaline sulfoconjugate: characterization and urinary excretion monitored by LC\/ESI\u2013MS\/MS","volume":"1","author":"Orlovius","year":"2009","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0140","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/dta.1388","article-title":"Identification and characterization of urinary prenylamine metabolites by means of liquid chromatography-tandem mass spectrometry","volume":"4","author":"Beuck","year":"2012","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0145","unstructured":"WADA International Standard for Laboratories. https:\/\/wada-main-prod.s3.amazonaws.com\/resources\/files\/WADA-ISL-2015-Final-v8.0-EN.pdf (2015) (accessed 12.05.16)."},{"key":"10.1016\/j.jpba.2016.09.015_bib0150","unstructured":"WADA Technical Document\u2013TD2014DL. https:\/\/wada-main-prod.s3.amazonaws.com\/resources\/files\/WADA-TD2014DL-v1-Decision-Limits-for-the-Quantification-of-Threshold-Substances-EN.pdf (accessed 12.05.16)."},{"key":"10.1016\/j.jpba.2016.09.015_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecl.2009.10.011","article-title":"Stimulants and doping in sport","volume":"39","author":"Thevis","year":"2010","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.jpba.2016.09.015_bib0160","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/jms.542","article-title":"Liquid chromatography\/electrospray ionization tandem mass spectrometric screening and confirmation methods for beta2-agonists in human or equine urine","volume":"38","author":"Thevis","year":"2003","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0165","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/bj1160425","article-title":"The metabolic fate of amphetamine in man and other species","volume":"116","author":"Dring","year":"1970","journal-title":"Biochem. J"},{"key":"10.1016\/j.jpba.2016.09.015_bib0170","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1248\/bpb.16.817","article-title":"Simultaneous determination of methamphetamine and its metabolites in the urine samples of abusers by high performance liquid chromatography with chemiluminescence detection","volume":"16","author":"Hayakawa","year":"1993","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jpba.2016.09.015_bib0175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00316321","article-title":"Urinary excretion of p-hydroxylated methamphetamine metabolites in man. I. A method for determination by high-performance liquid chromatography-electrochemistry","volume":"59","author":"Shimosato","year":"1986","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jpba.2016.09.015_bib0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/00498250600627475","article-title":"Urinary excretion of the main metabolites of methamphetamine, including p-hydroxymethamphetamine-sulfate and p-hydroxymethamphetamine-glucuronide, in humans and rats","volume":"36","author":"Shima","year":"2006","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jpba.2016.09.015_bib0185","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jchromb.2005.10.014","article-title":"Direct determination of glucuronide and sulfate of p-hydroxymethamphetamine in methamphetamine users\u2019 urine","volume":"830","author":"Shima","year":"2006","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2016.09.015_bib0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00614015","article-title":"The physiological disposition of etilefrine in man","volume":"9","author":"Hengstmann","year":"1975","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2016.09.015_bib0195","first-page":"307","article-title":"Clinical pharmacokinetics after a single oral dose of oxilofrine","volume":"8","author":"Kauert","year":"1988","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"10.1016\/j.jpba.2016.09.015_bib0200","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00500148","article-title":"The physiological disposition of p-octopamine in man","volume":"283","author":"Hengstmann","year":"1974","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.jpba.2016.09.015_bib0205","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/00498259409043222","article-title":"Fenoterol metabolism in man: sulphation versus glucuronidation","volume":"24","author":"Hildebrandt","year":"1994","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jpba.2016.09.015_bib0210","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000193807","article-title":"Absorption, distribution and excretion of the tritium-labelled beta2 stimulator fenoterol hydrobromide following aerosol administration and instillation into the bronchial tree","volume":"34","author":"Laros","year":"1977","journal-title":"Respiration"},{"key":"10.1016\/j.jpba.2016.09.015_bib0215","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4155\/bio.10.181","article-title":"Plasma volume expanders: use in medicine and detecting misuse in sports","volume":"3","author":"Simoni","year":"2011","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2016.09.015_bib0220","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jchromb.2006.02.044","article-title":"Detection of hydroxyethylstarch (HES) in human urine by liquid chromatography-mass spectrometry","volume":"834","author":"Deventer","year":"2006","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2016.09.015_bib0225","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0378-4347(00)00251-6","article-title":"Detection of the plasma volume expander hydroxyethyl starch in human urine","volume":"744","author":"Thevis","year":"2000","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.jpba.2016.09.015_bib0230","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/bmc.986","article-title":"Rapid screening of polysaccharide-based plasma volume expanders dextran and hydroxyethyl starch in human urine by liquid chromatography-tandem mass spectrometry","volume":"22","author":"Guddat","year":"2008","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2016.09.015_bib0235","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00216-011-4838-1","article-title":"Specific screening method for dextran and hydroxyethyl starch in human urine by size exclusion chromatography-in-source collision-induced dissociation-time-of-flight mass spectrometry","volume":"401","author":"Kolmonen","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2016.09.015_bib0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5604\/20831862.1096045","article-title":"Investigation of urinary excretion of hydroxyethyl starch and dextran by uhplc-hrms in different acquisition modes","volume":"31","author":"Esposito","year":"2014","journal-title":"Biol. Sport"},{"key":"10.1016\/j.jpba.2016.09.015_bib0245","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/dta.365","article-title":"Development of liquid chromatography-tandem mass spectrometry-based analytical assays for the determination of HIF stabilizers in preventive doping research","volume":"3","author":"Beuck","year":"2011","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0250","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/dta.390","article-title":"Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis","volume":"4","author":"Beuck","year":"2012","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0255","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jpba.2016.01.029","article-title":"Detection by LC\u2013MS\/MS of HIF stabilizer FG-4592 used as a new doping agent: investigation on a positive case","volume":"121","author":"Buisson","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0260","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1255\/ejms.917","article-title":"Screening for two selective androgen receptor modulators using gas chromatography-mass spectrometry in doping control analysis","volume":"14","author":"Thevis","year":"2008","journal-title":"Eur. J. Mass Spectrom. (Chichester, Engl.)"},{"key":"10.1016\/j.jpba.2016.09.015_bib0265","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/rcm.2389","article-title":"Screening for metabolically stable aryl-propionamide-derived selective androgen receptor modulators for doping control purposes","volume":"20","author":"Thevis","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0270","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1002\/rcm.3247","article-title":"Screening for 2-quinolinone-derived selective androgen receptor agonists in doping control analysis","volume":"21","author":"Thevis","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0275","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jms.1364","article-title":"Mass spectrometry of hydantoin-derived selective androgen receptor modulators","volume":"43","author":"Thevis","year":"2008","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0280","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00216-008-1882-6","article-title":"Determination of benzimidazole- and bicyclic hydantoin-derived selective androgen receptor antagonists and agonists in human urine using LC-MS\/MS","volume":"391","author":"Thevis","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2016.09.015_bib0285","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/rcm.3637","article-title":"Doping control analysis of tricyclic tetrahydroquinoline-derived selective androgen receptor modulators using liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"22","author":"Thevis","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0290","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1255\/ejms.924","article-title":"Use of an electrochemically synthesised metabolite of a selective androgen receptor modulator for mass spectrometry-based sports drug testing","volume":"14","author":"Thevis","year":"2008","journal-title":"Eur. J. Mass Spectrom. (Chichester, Engl.)"},{"key":"10.1016\/j.jpba.2016.09.015_bib0295","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jms.1438","article-title":"Mass spectrometry of selective androgen receptor modulators","volume":"43","author":"Thevis","year":"2008","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0300","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/rcm.5100","article-title":"Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls","volume":"25","author":"Thevis","year":"2011","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0305","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1016\/j.chroma.2011.05.073","article-title":"Mass spectrometric characterization of urinary toremifene metabolites for doping control analyses","volume":"1218","author":"Gomez","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0310","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1039\/C2AY05702F","article-title":"Mass spectrometric identification and characterization of new toremifene metabolites in human urine by liquid chromatography quadrupole\/time-of-flight tandem mass spectrometry (LC-QTOFMS)","volume":"4","author":"Lu","year":"2012","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jpba.2016.09.015_bib0315","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1039\/C0AN00487A","article-title":"Mass spectrometric characterization of toremifene metabolites in human urine by liquid chromatography-tandem mass spectrometry with different scan modes","volume":"136","author":"Lu","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.jpba.2016.09.015_bib0320","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00216-011-4695-y","article-title":"Urinary excretion profiles of toremifene metabolites by liquid chromatography-mass spectrometry. Towards targeted analysis to relevant metabolites in doping control","volume":"401","author":"Mazzarino","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2016.09.015_bib0325","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/j.jchromb.2011.06.031","article-title":"Determination of raloxifene and its glucuronides in human urine by liquid chromatography-tandem mass spectrometry assay","volume":"879","author":"Trdan","year":"2011","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2016.09.015_bib0330","first-page":"4487","article-title":"Excretion of hydroxylated metabolites of tamoxifen in human bile and urine","volume":"25","author":"Kisanga","year":"2005","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jpba.2016.09.015_bib0335","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0090-9556(25)08208-X","article-title":"Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients","volume":"21","author":"Poon","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2016.09.015_bib0340","first-page":"53","article-title":"Screening for tamoxifen, clomiphene and cyclofenil in doping analysis","volume":"vol. 9","author":"Mareck-Engelke Ute","year":"2001"},{"key":"10.1016\/j.jpba.2016.09.015_bib0345","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/jat\/bkt041","article-title":"Determination of raloxifene in urine by liquid chromatography-tandem mass spectrometry for doping","volume":"37","author":"Chen","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jpba.2016.09.015_bib0350","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.steroids.2011.06.005","article-title":"Relevance of the selective oestrogen receptor modulators tamoxifen, toremifene and clomiphene in doping field: endogenous steroids urinary profile after multiple oral doses","volume":"76","author":"Mazzarino","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.jpba.2016.09.015_bib0355","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-4347(89)80016-7","article-title":"Liquid chromatographic-atmospheric pressure ionization mass spectrometric analysis of toremifene metabolites in human urine","volume":"497","author":"Watanabe","year":"1989","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2016.09.015_bib0360","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1586\/14789450.2014.965159","article-title":"Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions","volume":"11","author":"Thevis","year":"2014","journal-title":"Expert Rev. Proteomics."},{"key":"10.1016\/j.jpba.2016.09.015_bib0365","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.chroma.2012.07.022","article-title":"Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography\/benchtop quadrupole orbitrap tandem-mass spectrometry","volume":"1259","author":"Thomas","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.09.015_bib0370","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/bmc.2782","article-title":"Doping control analysis of desmopressin in human urine by LC-ESI\u2013MS\/MS after urine delipidation","volume":"27","author":"Esposito","year":"2013","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2016.09.015_bib0375","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpba.2011.11.007","article-title":"Development and validation of a bioanalytical LC-MS method for the quantification of GHRP-6 in human plasma","volume":"60","author":"Gil","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0380","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1002\/rcm.4619","article-title":"Determination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"24","author":"Okano","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0385","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00216-011-4702-3","article-title":"Determination of growth hormone releasing peptides (GHRP) and their major metabolites in human urine for doping controls by means of liquid chromatography mass spectrometry","volume":"401","author":"Thomas","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2016.09.015_bib0390","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aca.2011.09.027","article-title":"Determination of Vasopressin and Desmopressin in urine by means of liquid chromatography coupled to quadrupole time-of-flight mass spectrometry for doping control purposes","volume":"707","author":"Thomas","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2016.09.015_bib0395","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4155\/bio.12.128","article-title":"Analytical challenges in the detection of peptide hormones for anti-doping purposes","volume":"4","author":"Barroso","year":"2012","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2016.09.015_bib0400","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/dta.1787","article-title":"Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin","volume":"7","author":"Semenistaya","year":"2015","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2016.09.015_bib0405","series-title":"Recent Advances in Doping Analysis","first-page":"33","author":"Guddat","year":"2013"},{"key":"10.1016\/j.jpba.2016.09.015_bib0410","unstructured":"WADA Anti-Doping Testing Figures. https:\/\/wada-main-prod.s3.amazonaws.com\/wada_2014_anti-doping-testing-figures_full-report_en.pdf (2014) (accessed 12.05.16)."},{"key":"10.1016\/j.jpba.2016.09.015_bib0415","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/rcm.2587","article-title":"Mass spectrometric identification and characterization of a new long-term metabolite of metandienone in human urine","volume":"20","author":"Sch\u00e4nzer","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.09.015_bib0420","series-title":"Proceedings of the Manfred-Donike-Workshop, 28th Cologne Workshop on Dope Analysis","first-page":"64","article-title":"Recent advances in doping analysis (18)","author":"Maria Kristina Parr","year":"2010"},{"key":"10.1016\/j.jpba.2016.09.015_bib0425","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1007\/s00216-015-8699-x","article-title":"Dilute-and-inject multi-target screening assay for highly polar doping agents using hydrophilic interaction liquid chromatography high resolution\/high accuracy mass spectrometry for sports drug testing","volume":"407","author":"G\u00f6rgens","year":"2015","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516306033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516306033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T19:26:23Z","timestamp":1749583583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708516306033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":85,"alternative-id":["S0731708516306033"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2016.09.015","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution\/high accuracy mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2016.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}