{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:27:38Z","timestamp":1776184058716,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jpba.2016.12.035","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T19:18:11Z","timestamp":1483039091000},"page":"66-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Molecular insight into atypical instability behavior of fixed-dose combination containing amlodipine besylate and losartan potassium"],"prefix":"10.1016","volume":"136","author":[{"given":"Tarun","family":"Handa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalu","family":"Jhajra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.V.","family":"Bharatam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asit K.","family":"Chakraborti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saranjit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2016.12.035_bib0005","unstructured":"http:\/\/www.reginfo.gov\/public\/do\/eAgendaViewRule?pubId=201504&RIN=0910-AF89 (Assessed 30 June 2016)."},{"key":"10.1016\/j.jpba.2016.12.035_bib0010","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1211\/146080800128736277","article-title":"The reason for an increase in decomposition of rifampicin in the presence of isoniazid under acid conditions","volume":"6","author":"Singh","year":"2000","journal-title":"Pharm. Pharmacol. Commun."},{"key":"10.1016\/j.jpba.2016.12.035_bib0015","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jpba.2005.05.015","article-title":"Mechanistic explanation to the catalysis by pyrazinamide and ethambutol of reaction between rifampicin and isoniazid in anti-TB FDCs","volume":"39","author":"Bhutani","year":"2005","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0020","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/10837450500299982","article-title":"Drug-drug interaction studies on first-line anti-tuberculosis drugs","volume":"10","author":"Bhutani","year":"2005","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jpba.2016.12.035_bib0025","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.jpba.2006.03.004","article-title":"Study of the interaction between rifapentine and isoniazid under acid conditions","volume":"41","author":"Prasad","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0030","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jpba.2008.06.003","article-title":"Polypill for the treatment of cardiovascular diseases: part 2. LC\u2013MS\/TOF characterization of interaction\/degradation products of atenolol\/lisinopril and aspirin, and mechanisms of formation thereof","volume":"48","author":"Kumar","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jpba.2013.10.024","article-title":"Characterization of a new degradation product of nifedipine formed on catalysis by atenolol: a typical case of alteration of degradation pathway of one drug by another","volume":"89","author":"Handa","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0040","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jpba.2016.03.039","article-title":"Stability behaviour of antiretroviral drugs and their combinations. 2: characterization of interaction products of lamivudine and tenofovir disoproxil fumarate by mass and NMR spectrometry","volume":"125","author":"Kurmi","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0045","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jpba.2016.06.021","article-title":"Stability behaviour of antiretroviral drugs and their combinations. 3: characterization of interaction products of emtricitabine and tenofovir disoproxil fumarate by mass spectrometry","volume":"128","author":"Kurmi","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0050","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/jch.12390","article-title":"Evaluation of blood pressure reduction response and responder characteristics to fixed-dose combination treatment of amlodipine and losartan: a post hoc analysis of pooled clinical trials","volume":"16","author":"Unniachan","year":"2014","journal-title":"J. Clin. Hypertens"},{"key":"10.1016\/j.jpba.2016.12.035_bib0055","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3109\/10641963.2014.995802","article-title":"Visit-to-visit variability and seasonal variation in blood pressure: combination of antihypertensive therapy in the elderly, multicenter investigation (CAMUI) trial subanalysis","volume":"37","author":"Sato","year":"2015","journal-title":"Clin. Exp. Hypertens"},{"key":"10.1016\/j.jpba.2016.12.035_bib0060","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40885-016-0046-9","article-title":"Changes of blood pressure, abdominal visceral fat tissue and gene expressions in fetal programming induced rat model after amlodipine-losartan combination treatment","volume":"22","author":"Lee","year":"2016","journal-title":"Clin. Hypertens"},{"key":"10.1016\/j.jpba.2016.12.035_bib0065","unstructured":"J.H. Park, K.S. Kim, H.T. Yim, J.H. Im, Solid pharmaceutical composition comprising amlodipine and losartan with improved stability, Korea, Patent WO 2010\/085027."},{"key":"10.1016\/j.jpba.2016.12.035_bib0070","unstructured":"J.S. Woo, H.G. Yi, M.H. Chi, K.S. Kim, Pharmaceutical composition comprising amlodipine and losartan, Hwaseong-gun (Korea), Patent US 20100233261."},{"key":"10.1016\/j.jpba.2016.12.035_bib0075","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chroma.2007.12.038","volume":"1181","author":"Murakami","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2016.12.035_bib0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijpharm.2007.10.040","article-title":"Mechanism of the photochemical degradation of amlodipine","volume":"352","author":"Fasani","year":"2008","journal-title":"Inter. J. Pharm."},{"key":"10.1016\/j.jpba.2016.12.035_bib0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1081\/PDT-120027414","article-title":"Amlodipine besylate\u2013excipients interaction in solid dosage form","volume":"9","author":"Abdoh","year":"2004","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jpba.2016.12.035_bib0090","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/mrc.2022","article-title":"Structure elucidation of thermal degradation products of amlodipine","volume":"45","author":"Devi","year":"2007","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jpba.2016.12.035_bib0095","doi-asserted-by":"crossref","first-page":"X91","DOI":"10.2116\/analscix.23.x91","article-title":"Crystal structure of 9-ethyl-7-methyl-8-(2-chlorophenyl)-6-methyl-3,4,8,9-tetrahydropyrido [2,1-c][1,4] oxazine-7,9-dicarboxylate (amlodipine degradation product)","volume":"23","author":"Devi","year":"2007","journal-title":"X-ray Struct. Anal. Online"},{"key":"10.1016\/j.jpba.2016.12.035_bib0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0731-7085(99)00004-7","article-title":"Identification of losartan degradates in stressed tablets by LC\u2013MS and LC\u2013MS\/MS","volume":"20","author":"Zhao","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jpba.2006.04.030","article-title":"Photosensitized degradation of losartan potassium in an extemporaneous suspension formulation","volume":"42","author":"Seburg","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0110","series-title":"International Conference on Harmonisation","article-title":"Stability testing of new drugs substances and products Q1A(R2)","author":"ICH","year":"2003"},{"key":"10.1016\/j.jpba.2016.12.035_bib0115","series-title":"International Conference on Harmonisation","article-title":"Photostability testing of new drugs substances and products Q1B","author":"ICH","year":"1996"},{"key":"10.1016\/j.jpba.2016.12.035_bib0120","first-page":"1","article-title":"Guidance on conduct of stress tests to determine inherent stability of drugs","volume":"24","author":"Singh","year":"2000","journal-title":"Pharm. Tech. On-Line"},{"key":"10.1016\/j.jpba.2016.12.035_bib0125","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1021\/js980434g","article-title":"Selection of solid dosage form composition through drug-excipient compatibility testing","volume":"88","author":"Serajuddin","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2016.12.035_bib0130","series-title":"Density-Functional Theory","author":"Parr","year":"1989"},{"key":"10.1016\/j.jpba.2016.12.035_bib0135","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional thermochemistry. III. The role of exact exchange","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jpba.2016.12.035_bib0140","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.jpba.2016.12.035_bib0145","series-title":"Gaussian 09 Revision B.01 Release Notes","author":"Frisch","year":"2010"},{"key":"10.1016\/j.jpba.2016.12.035_bib0150","series-title":"Clarke\u2019s Analysis of Drugs and Poisons","author":"Moffat","year":"2011"},{"key":"10.1016\/j.jpba.2016.12.035_bib0155","unstructured":"E. Davisonand J.I. Wells, Pharmaceutically Acceptable Salts, New York (USA), Patent US 4879303."},{"key":"10.1016\/j.jpba.2016.12.035_bib0160","first-page":"9770","volume":"vol. 4611","author":"Maryadele","year":"2001"},{"key":"10.1016\/j.jpba.2016.12.035_bib0165","unstructured":"C. Castan, F., Guimberteau, R., Meyrueixand G. Soula, Oral pharmaceutical form of losartan, Virginia (USA), Patent US 20090123536."},{"key":"10.1016\/j.jpba.2016.12.035_bib0170","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jpba.2013.04.027","article-title":"Critical practical aspects in the application of liquid chromatography\u2013mass spectrometric studies for the characterization of impurities and degradation products","volume":"87","author":"Narayanam","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0175","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jpba.2012.03.044","article-title":"A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products","volume":"69","author":"Singh","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2016.12.035_bib0180","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/(SICI)1096-9888(199608)31:8<879::AID-JMS373>3.0.CO;2-F","article-title":"Quantitative determination of amlodipine in serum by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry","volume":"31","author":"Yasuda","year":"1996","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2016.12.035_bib0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1365\/s10337-008-0620-8","article-title":"Amlodipine besilate screening in pharmaceutical preparations by CE","volume":"68","author":"Jankovics","year":"2008","journal-title":"Chromatographia"},{"key":"10.1016\/j.jpba.2016.12.035_bib0190","unstructured":"European Pharmacopoeia 2005, Amlodipine Besilate, pp. 981\u2013983."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516306227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708516306227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T12:23:33Z","timestamp":1536150213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708516306227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":38,"alternative-id":["S0731708516306227"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2016.12.035","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular insight into atypical instability behavior of fixed-dose combination containing amlodipine besylate and losartan potassium","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2016.12.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}