{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T22:15:14Z","timestamp":1786313714396,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Community\u2019s Seventh Framework Programme","award":["602051"],"award-info":[{"award-number":["602051"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jpba.2017.03.021","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T22:33:23Z","timestamp":1489703603000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Enantiomers of triclabendazole sulfoxide: Analytical and semipreparative HPLC separation, absolute configuration assignment, and transformation into sodium salt"],"prefix":"10.1016","volume":"140","author":[{"given":"Rosella","family":"Ferretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Carradori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pierini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Casulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cirilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2017.03.021_bib0005","first-page":"300","article-title":"New opportunities for the control of fascioliasis","volume":"77","author":"Savioli","year":"1999","journal-title":"Bull. WHO"},{"key":"10.1016\/j.jpba.2017.03.021_bib0010","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.tmaid.2014.09.006","article-title":"Fascioliasis A worldwide parasitic disease of importance in travel medicine","volume":"12","author":"Ashrafi","year":"2014","journal-title":"Travel. Med. Infect. Dis."},{"key":"10.1016\/j.jpba.2017.03.021_bib0015","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1007\/s00436-013-3321-7","article-title":"In vitro efficacy of triclabendazole and clorsulon against the larval stage of Echinococcus multilocularis","volume":"112","author":"Richter","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jpba.2017.03.021_bib0020","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1517\/13543784.14.12.1513","article-title":"Triclabendazole for the treatment of fascioliasis and paragonimiasis","volume":"14","author":"Keiser","year":"2005","journal-title":"Expert. Opin. Invest. Drugs"},{"key":"10.1016\/j.jpba.2017.03.021_bib0025","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1080\/00498250400015285","article-title":"Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica","volume":"34","author":"Mottier","year":"2004","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jpba.2017.03.021_bib0030","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3109\/00498259109039463","article-title":"Comparative enantioselectivity in the sulphoxidation of albendazole in man, dogs and rats","volume":"21","author":"Delatour","year":"1991","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jpba.2017.03.021_bib0035","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1128\/AAC.01465-12","article-title":"In vitro analysis of albendazole sulfoxide enantiomers shows that (+)-(R)-albendazole sulfoxide is the active enantiomer against Taenia solium","volume":"57","author":"Paredes","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jpba.2017.03.021_bib0040","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1128\/AAC.06345-11","article-title":"The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2\/BCRP","volume":"56","author":"Barrera","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jpba.2017.03.021_bib0045","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.exppara.2013.10.014","article-title":"Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep","volume":"136","author":"Moreno","year":"2014","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jpba.2017.03.021_bib0050","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00436-003-1003-6","article-title":"The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica","volume":"92","author":"Robinson","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jpba.2017.03.021_bib0055","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s00436-011-2304-9","article-title":"Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica","volume":"109","author":"Devine","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jpba.2017.03.021_bib0060","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.vetpar.2008.10.007","article-title":"Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica","volume":"159","author":"Halferty","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.jpba.2017.03.021_bib0065","first-page":"1","article-title":"Triclabendazole sulfoxide causes stage-dependent embryolethality in zebrafish and mouse in vitro","volume":"20","author":"Boix","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2017.03.021_bib0070","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0021-9673(00)00054-6","article-title":"Simultaneous determination of triclabendazole and its sulphoxide and sulphone metabolites in bovine milk by high-performance liquid chromatography","volume":"882","author":"Takeba","year":"2000","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0075","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.vetpar.2012.11.033","article-title":"Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole","volume":"193","author":"Sanabria","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.jpba.2017.03.021_bib0080","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-62703-263-6_6","article-title":"Common screening approaches for efficient analytical method development in LC and SFC on columns packed with immobilized polysaccharide-derived chiral stationary phases","volume":"970","author":"Franco","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jpba.2017.03.021_bib0085","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.chroma.2007.12.026","article-title":"Enantiomer resolution screening strategy using multiple immobilised polysaccharide-based chiral stationary phases","volume":"1191","author":"Zhang","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0090","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.chroma.2009.11.040","article-title":"Reversed-phase screening strategies for liquid chromatography on polysaccharide-derived chiral stationary phases","volume":"1217","author":"Zhang","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0095","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1002\/jssc.201501329","article-title":"Green high-performance liquid chromatography enantioseparation of lansoprazole using a cellulose-based chiral stationary phase under ethanol\/water mode","volume":"39","author":"Ferretti","year":"2016","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2017.03.021_bib0100","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jpha.2015.11.001","article-title":"Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances","volume":"6","author":"Gallinella","year":"2016","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpba.2017.03.021_bib0105","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1002\/jssc.200800044","article-title":"Enantioseparation of kavain on Chiralpak IA under normal-phase, polar organic and reversed-phase conditions","volume":"31","author":"Cirilli","year":"2008","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2017.03.021_bib0110","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.chroma.2008.02.101","article-title":"High-performance liquid chromatography separation of enantiomers of flavanone and 2 -hydroxychalcone under reversed-phase conditions","volume":"1190","author":"Cirilli","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0115","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.chroma.2013.12.051","article-title":"Effect of the water content on the retention and enantioselectivity of albendazole and fenbendazole sulfoxides using amylose-based chiral stationary phases in organic\u2013aqueous conditions","volume":"1327","author":"Materazzo","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0120","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/jssc.200800051","article-title":"Stationary phases for hydrophilic interaction chromatography, their characterization and implementation into multidimensional chromatography concepts","volume":"31","author":"Jandera","year":"2008","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2017.03.021_bib0125","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.chroma.2014.02.071","article-title":"Direct separation of the enantiomers of oxaliplatin on a cellulose-based chiral stationary phase in hydrophilic interaction liquid chromatography mode","volume":"1339","author":"Gallinella","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0130","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.chroma.2013.07.021","article-title":"Retention behavior of proton pump inhibitors using immobilized polysaccharide-derived chiral stationary phases with organic-aqueous mobile phases","volume":"1304","author":"Cirilli","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0135","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.chroma.2012.10.033","article-title":"Recent developments on polysaccharide-based chiral stationary phases for liquid-phase separation of enantiomers","volume":"1269","author":"Chankvetadze","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.03.021_bib0140","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1002\/jssc.201200443","article-title":"HPLC separation of dihydropyridine derivatives enantiomers with emphasis on elution order using polysaccharide-based chiral columns","volume":"35","author":"Jibuti","year":"2012","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2017.03.021_bib0145","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1002\/jps.20282","article-title":"Physicochemical characterization of ricobendazole: I. solubility, lipophilicity, and ionization characteristics","volume":"94","author":"Wu","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2017.03.021_bib0150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jpba.2017.01.057","article-title":"The sodium salt of the enantiomers of ricobendazole: preparation, solubility and chiroptical properties","volume":"139","author":"Cirilli","year":"2017","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517303400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517303400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T12:58:48Z","timestamp":1535979528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708517303400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":30,"alternative-id":["S0731708517303400"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2017.03.021","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enantiomers of triclabendazole sulfoxide: Analytical and semipreparative HPLC separation, absolute configuration assignment, and transformation into sodium salt","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2017.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}