{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:25:20Z","timestamp":1787502320147,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jpba.2017.06.001","type":"journal-article","created":{"date-parts":[[2017,6,3]],"date-time":"2017-06-03T00:30:35Z","timestamp":1496449835000},"page":"269-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Dual-target screening of bioactive components from traditional Chinese medicines by hollow fiber-based ligand fishing combined with liquid chromatography\u2013mass spectrometry"],"prefix":"10.1016","volume":"143","author":[{"given":"Liang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2017.06.001_bib0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.trac.2014.06.007","article-title":"Metabolomics and traditional Chinese medicine","volume":"61","author":"Hu","year":"2014","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0010","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.drudis.2009.03.012","article-title":"Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives","volume":"14","author":"Ma","year":"2009","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jpba.2017.06.001_bib0015","first-page":"55","article-title":"Screening and identification of BSA bound ligands from Puerariae lobata flower by BSA functionalized Fe3O4 magnetic nanoparticles coupled with HPLC\u2013MS\/MS","volume":"887\u2013888","author":"Liu","year":"2012","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0020","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1016\/j.chroma.2010.06.039","article-title":"Chemical markers\u2019 fishing and knockout for holistic activity and interaction evaluation of the components in herbal medicines","volume":"217","author":"Liu","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.06.001_bib0025","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jpba.2006.01.014","article-title":"Live cell extraction and HPLC\u2013MS analysis for predicting bioactive components of traditional Chinese medicines","volume":"41","author":"Li","year":"2006","journal-title":"J. Pharm. Biomed Anal."},{"key":"10.1016\/j.jpba.2017.06.001_bib0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpba.2012.11.009","article-title":"Application of an efficient strategy for discovery and purification of bioactive compounds from Chinese herbal medicines, a case study on the Puerariae thomsonii Flos","volume":"75","author":"Wang","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2017.06.001_bib0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.foodchem.2016.03.079","article-title":"Antioxidants and (-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships","volume":"208","author":"Zhang","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.antiviral.2008.12.004","article-title":"High-throughput screening using pseudotyped lentiviral particles: a strategy for the identification of HIV-1 inhibitors in a cell-based assay","volume":"81","author":"Garcia","year":"2009","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jpba.2017.06.001_bib0045","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jconrel.2014.06.045","article-title":"High throughput screening for biomaterials discovery","volume":"190","author":"Algahtani","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpba.2017.06.001_bib0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/B978-008045382-8.00062-9","article-title":"The identification of bioactive natural products by high throughput screening (HTS)","volume":"3","author":"Avery","year":"2010","journal-title":"Compr. Natur. Prod. II"},{"key":"10.1016\/j.jpba.2017.06.001_bib0055","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3390\/molecules21111516","article-title":"Ligand fishing: a remarkable strategy for discovering bioactive compounds from complex mixture of natural products","volume":"21","author":"Zhuo","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2017.06.001_bib0060","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/bmc.1070","article-title":"Screening and analyzing the potential bioactive components from Shaofu Zhuyu decoction, using human umbilical vein endothelial cell extraction and high-performance liquid chromatography coupled with mass spectrometry","volume":"22","author":"Su","year":"2008","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2017.06.001_bib0065","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jchromb.2014.05.001","article-title":"Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC\u2013MS combined with enzyme channel blocking","volume":"961","author":"Song","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2013.01.035","article-title":"Studies on the interactions between ginsenosides and liposome by equilibrium dialysis combined with ultrahigh performance liquid chromatography-tandem mass spectrometry","volume":"923","author":"Hou","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0075","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.talanta.2011.04.011","article-title":"Fishing potential antitumor agents from natural plant extracts pool by dialysis and G-quadruplex recognition","volume":"85","author":"Shang","year":"2011","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2017.06.001_bib0080","doi-asserted-by":"crossref","first-page":"10940","DOI":"10.1021\/ac503261b","article-title":"Just in time-selection: a rapid semiautomated SELEX of DNA aptamers using magnetic separation and BEAMing","volume":"86","author":"H\u00fcnniger","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1087057104270270","article-title":"A method for screening enzyme inhibitors using size exclusion chromatography and ESI-LC-MS\/MS","volume":"10","author":"Mathur","year":"2005","journal-title":"J. Biomo. Screen."},{"key":"10.1016\/j.jpba.2017.06.001_bib0090","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1007\/s00216-014-7902-9","article-title":"Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae","volume":"406","author":"Fu","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0095","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1007\/s00216-014-7790-z","article-title":"New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k\/Akt\/m TOR signaling pathway","volume":"406","author":"Nehm\u00e9","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-313X.2007.03204.x","article-title":"Functional immobilization of plant receptor-like kinase onto microbeads towards receptor array construction and receptor-based ligand fishing","volume":"52","author":"Shinohara","year":"2007","journal-title":"Plant J."},{"key":"10.1016\/j.jpba.2017.06.001_bib0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chroma.2005.04.031","article-title":"Screening and analysis of bioactive compounds with biofingerprinting chromatogram analysis of traditional Chinese medicines targeting DNA by microdialysis\/HPLC","volume":"1076","author":"Su","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.06.001_bib0110","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.phrs.2010.02.007","article-title":"R.B. van Breemen, Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation","volume":"61","author":"Cao","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jpba.2017.06.001_bib0115","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jchromb.2013.09.032","article-title":"Simultaneous ligand fishing and identification of human serum albumin binders from Eucommia ulmoides bark using surface plasmon resonance-high performance liquid chromatography?tandem mass spectrometry","volume":"940","author":"Peng","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0120","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1021\/jf503687e","article-title":"Lipase ligands in Nelumbo nucifera leaves and study of their binding mechanism","volume":"62","author":"Zhu","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jchromb.2014.10.010","article-title":"Magnetic ligand fishing combination with high-performance liquid chromatography\u2013diodearray detector\u2013mass spectrometry to screen and characterize cyclooxygenase-2 inhibitors from green tea","volume":"973","author":"Deng","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0130","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00216-010-4399-8","article-title":"Ligand fishing with functionalized magnetic nanoparticles coupled with mass spectrometry for herbal medicine analysis: ligand fishing for herbal medicine analysis","volume":"399","author":"Qing","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0135","first-page":"8","article-title":"Screening of inhibitors of glycogen synthase kinase-3(from traditional Chinese medicines using enzyme-immobilized magnetic beads combined with high-performance liquid chromatography","volume":"2015","author":"Li","year":"1425","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.06.001_bib0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchromb.2008.06.036","article-title":"Development of high performance liquid chromatography with immobilized enzyme onto magnetic nanospheres for screening enzyme inhibitor","volume":"871","author":"Hu","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0145","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jchromb.2014.04.032","article-title":"Functionalized magnetic nanoparticles coupled with mass spectrometry for screening and identification of cyclooxygenase-1 inhibitors from natural products","volume":"960","author":"Zhang","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0150","first-page":"109","article-title":"Recent developments in modifying polypropylene hollow fibers for sample preparation, Trends Anal","volume":"64","author":"Yang","year":"2015","journal-title":"Chem"},{"key":"10.1016\/j.jpba.2017.06.001_bib0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.chroma.2014.01.002","article-title":"Gas chromatography\u2013mass spectrometry determination of earthy\u2013musty odorous compounds in waters by two phase hollow-fiber liquid-phase microextraction using polyvinylidene fluoride fibers","volume":"1329","author":"Yu","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.06.001_bib0160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/bmc.3022","article-title":"Simultaneous determination of three purines in Alysicarpus vaginalis (L.) DC. by hollow fiber based liquid-phase microextraction combined with high-performance liquid chromatography","volume":"28","author":"Liu","year":"2014","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2017.06.001_bib0165","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-4347(00)00311-X","article-title":"Human serum albumin chromatography by Cibacron Blue F3GA-derived microporous polyamide hollow-fiber affinity membranes","volume":"746","author":"Kassab","year":"2000","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.06.001_bib0170","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.foodchem.2014.09.092","article-title":"Vortex-assisted hollow fibre liquid-phase microextraction technique combined with high performance liquid chromatography-diode array detection for the determination of oestrogens in milk samples","volume":"172","author":"Wang","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.chroma.2013.01.033","article-title":"Hollow fiber cell fishing with high performance liquid chromatography for screening bioactive compounds from traditional Chinese medicines","volume":"1280","author":"Xue","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2017.06.001_bib0180","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.aca.2013.04.058","article-title":"Hollow fiber based affinity selection combined with high performance liquid chromatography\u2013mass spectroscopy for rapid screening lipase inhibitors from lotus leaf","volume":"785","author":"Tao","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2017.06.001_bib0185","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0014-2999(01)00909-8","article-title":"Neurovascular interactions between aldose reductase and angiotensin-converting enzyme inhibition in diabetic rats","volume":"417","author":"Cotter","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpba.2017.06.001_bib0190","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jep.2016.03.060","article-title":"Screening for potential (-glucosidase and (-amylase inhibitory constituents from selected Vietnamese plants used to treat type2 diabetes","volume":"186","author":"Trinh","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2017.06.001_bib0195","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pmedr.2016.01.005","article-title":"Utilization of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in patients diagnosed with diabetes: analysis from the National Ambulatory Medical Care Survey","volume":"3","author":"Ibrahim","year":"2016","journal-title":"Prev. Med. Rep."},{"key":"10.1016\/j.jpba.2017.06.001_bib0200","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jff.2014.12.003","article-title":"Chemical profile and inhibition of (-glycosidase and protein tyrosine phosphatase 1 B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch)","volume":"14","author":"Guo","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.jpba.2017.06.001_bib0205","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.foodchem.2009.12.027","article-title":"Influence of degree of hydrolysis on functional properties, antioxidant activity and ACE inhibitory activity of peanut protein hydrolysate","volume":"121","author":"Jamdar","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.trac.2013.02.015","article-title":"Developments in ultrasound-assisted microextraction techniques for isolation and preconcentration of organic analytes from aqueous samples","volume":"49","author":"Sztajnert","year":"2013","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jpba.2017.06.001_bib0215","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpba.2012.09.015","article-title":"C. xiang, X. guangD. guo,Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC\/DAD\/qTOF-MS","volume":"72","author":"Miao","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2017.06.001_bib0220","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jpba.2014.07.025","article-title":"An activity-integrated strategy involving ultra-high-performance liquid chromatography\/quadrupole-time-of-flight mass spectrometry and fraction collector for rapid screening and characterization of the (-glucosidase inhibitors in Coptis chinensis Franch","volume":"100","author":"Ge","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2014","key":"10.1016\/j.jpba.2017.06.001_bib0225","article-title":"Screening for potential \u2212(\u2212Glucosidase inhibitors in Coptis chinensis franch extract using ultrafiltration LC-ESI\u2013MSn","volume":"27","author":"Zhou","year":"2007","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2017.06.001_bib0230","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/13880209.2011.608076","article-title":"Inhibitory activities of baicalin against renin and angiotensin-converting enzyme","volume":"50","author":"Deng","year":"2012","journal-title":"Pharm. Biolo."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851730506X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851730506X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T01:22:31Z","timestamp":1535764951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170851730506X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":46,"alternative-id":["S073170851730506X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2017.06.001","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-target screening of bioactive components from traditional Chinese medicines by hollow fiber-based ligand fishing combined with liquid chromatography\u2013mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2017.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}