{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:30:01Z","timestamp":1774845001019,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001305","name":"Christopher Reeve Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001305","id-type":"DOI","asserted-by":"crossref"}]},{"name":"United States Army Medical Research and Materiel Command"},{"name":"AOSpine North America"},{"name":"AOSpine International and Mission Connect"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jpba.2017.08.045","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T16:46:20Z","timestamp":1504284380000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["UPLC\u2013MS\/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients"],"prefix":"10.1016","volume":"146","author":[{"given":"Mahua","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Toups","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana S.-L.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6 Suppl. 4","key":"10.1016\/j.jpba.2017.08.045_bib0005","doi-asserted-by":"crossref","first-page":"S233","DOI":"10.1212\/WNL.47.6_Suppl_4.233S","article-title":"The pharmacology and mechanism of action of riluzole","volume":"47","author":"Doble","year":"1996","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jpba.2017.08.045_bib0010","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.3390\/molecules20057775","article-title":"Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside","volume":"20","author":"Nagoshi","year":"2015","journal-title":"Molecules"},{"issue":"5\u20136","key":"10.1016\/j.jpba.2017.08.045_bib0015","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.wneu.2013.01.001","article-title":"Riluzole for acute traumatic spinal cord injury: a promising neuroprotective treatment strategy","volume":"81","author":"Wilson","year":"2014","journal-title":"World Neurosurg."},{"issue":"1","key":"10.1016\/j.jpba.2017.08.045_bib0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1176\/appi.ajp.161.1.171","article-title":"An open-label trial of riluzole in patients with treatment-resistant major depression","volume":"161","author":"Zarate","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.jpba.2017.08.045_bib0025","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.biopsych.2004.11.023","article-title":"An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression","volume":"57","author":"Zarate","year":"2005","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.jpba.2017.08.045_bib0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00213-003-1396-z","article-title":"Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder","volume":"167","author":"Coric","year":"2003","journal-title":"Psychopharmacology (Berl.)"},{"issue":"6","key":"10.1016\/j.jpba.2017.08.045_bib0035","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/cap.2007.0021","article-title":"An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder","volume":"17","author":"Grant","year":"2007","journal-title":"J. Child Adolesc. Psychopharmacol."},{"issue":"9","key":"10.1016\/j.jpba.2017.08.045_bib0040","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.biopsych.2007.09.012","article-title":"Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder","volume":"63","author":"Mathew","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.jpba.2017.08.045_bib0045","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/01.jcp.0000245567.29531.d6","article-title":"Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors","volume":"26","author":"Sasso","year":"2006","journal-title":"J. Clin. Psychopharmacol."},{"issue":"1 Suppl","key":"10.1016\/j.jpba.2017.08.045_bib0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3171\/2012.5.AOSPINE12112","article-title":"Pharmacology of riluzole in acute spinal cord injury","volume":"17","author":"Chow","year":"2012","journal-title":"J. Neurosurg. Spine"},{"issue":"3","key":"10.1016\/j.jpba.2017.08.045_bib0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/neu.2013.2969","article-title":"A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury","volume":"31","author":"Grossman","year":"2014","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.jpba.2017.08.045_bib0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sc.2015.95","article-title":"Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial","volume":"54","author":"Fehlings","year":"2016","journal-title":"Spinal Cord"},{"issue":"9","key":"10.1016\/j.jpba.2017.08.045_bib0065","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/j.1552-4604.1997.tb05630.x","article-title":"Single- and multiple-dose pharmacokinetics of riluzole in white subjects","volume":"37","author":"Le Liboux","year":"1997","journal-title":"J. Clin. Pharmacol."},{"issue":"9","key":"10.1016\/j.jpba.2017.08.045_bib0070","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/bmc.384","article-title":"A validated HPLC assay to monitor riluzole plasma or serum concentrations in patients with amyotrophic lateral sclerosis","volume":"18","author":"van Kan","year":"2004","journal-title":"Biomed. Chromatogr."},{"issue":"1","key":"10.1016\/j.jpba.2017.08.045_bib0075","first-page":"5","article-title":"LC\u2013MS\/MS in the clinical laboratory \u2014 where to from here?","volume":"32","author":"Grebe","year":"2011","journal-title":"Clin. Biochem. Rev."},{"issue":"5","key":"10.1016\/j.jpba.2017.08.045_bib0080","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/009127009903900507","article-title":"A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteers","volume":"39","author":"Le Liboux","year":"1999","journal-title":"J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.jpba.2017.08.045_bib0085","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00216-010-4034-8","article-title":"Quantitative estimation of riluzole in human plasma by LC-ESI-MS\/MS and its application to a bioequivalence study","volume":"398","author":"Chandu","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2017.08.045_bib0090","series-title":"Guidance for Industry Bioanalytical Method Validation","year":"2013"},{"issue":"1-2","key":"10.1016\/j.jpba.2017.08.045_bib0095","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aca.2004.08.055","article-title":"The ion suppression phenomenon in liquid chromatography-mass spectrometry and its consequences in the field of residue","volume":"529","author":"Antignac","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2017.08.045_bib0100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.chroma.2012.08.029","article-title":"Matrix effects and recovery calculations in analyses of pharmaceuticals based on the determination of beta-blockers and beta-agonists in environmental samples","volume":"1258","author":"Caban","year":"2012","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851731453X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851731453X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:09:52Z","timestamp":1692947392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170851731453X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":20,"alternative-id":["S073170851731453X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2017.08.045","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UPLC\u2013MS\/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2017.08.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}