{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:57:20Z","timestamp":1793109440266,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Universit\u00e0 del Piemonte Orientale"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jpba.2017.12.018","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T18:56:47Z","timestamp":1512845807000},"page":"248-257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Troxerutin, a mixture of O -hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects"],"prefix":"10.1016","volume":"150","author":[{"given":"Michele","family":"Bianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Canavesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Aprile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Grosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Del Grosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2017.12.018_bib0005","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cclet.2013.01.016","article-title":"Synthesis and antioxidant activities of flavonoid derivatives, troxerutin and 3\u2019, 4\u2019, 7-triacetoxyethoxyquercetin","volume":"24","author":"Xu","year":"2013","journal-title":"Chin. Chem. Lett."},{"issue":"2","key":"10.1016\/j.jpba.2017.12.018_bib0010","first-page":"147","article-title":"Phytoplasma in fava d'anta tree (Dimorphandra gardneriana) in Brazil","volume":"60","author":"Montano","year":"2007","journal-title":"Bull. of Insectol."},{"key":"10.1016\/j.jpba.2017.12.018_bib0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1350-4177(00)00075-4","article-title":"The extraction of rutin from flower buds of Sophora japonica","volume":"8","author":"Paniwnyk","year":"2001","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.jpba.2017.12.018_bib0020","series-title":"European Pharmacopoeia","first-page":"3856","year":"2017"},{"key":"10.1016\/j.jpba.2017.12.018_bib0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0308-8146(00)00092-3","article-title":"The predictive value of the antioxidant capacity of structurally related flavonoids using the Trolox equivalent antioxidant capacity (TEAC) assay","volume":"70","author":"van den Berg","year":"2000","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2017.12.018_bib0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1211\/002235702559","article-title":"Anti- and pro-oxidant activity of rutin and quercetin derivatives","volume":"55","author":"Kessler","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jpba.2017.12.018_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.intimp.2008.10.008","article-title":"Troxerutin protects the mouse kidney from D-galactose-caused injury through anti-inflammation and anti-oxidation","volume":"9","author":"Fan","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jpba.2017.12.018_bib0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.foodchem.2015.07.078","article-title":"Troxerutin, a plant flavonoid, protects cells against oxidative stress-induced cell death through radical scavenging mechanism","volume":"194","author":"Panat","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2017.12.018_bib0045","first-page":"355","article-title":"Effects of troxerutin on cognitive dificits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats","volume":"2017","author":"Zhang","year":"1657","journal-title":"Brain Res."},{"key":"10.1016\/j.jpba.2017.12.018_bib0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2014.03.018","article-title":"Effect of troxerutin on synaptic plasticity of hippocampal dentate gyrus neurons in a (-amyloid model of Alzheimer's disease: an electrophysiological study","volume":"732","author":"Babri","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpba.2017.12.018_bib0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2017.03.002","article-title":"Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson\u2019s disease: possible involment of PI3 K\/ER\u03b2 signaling","volume":"801","author":"Baluchnejadmojarad","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpba.2017.12.018_bib0060","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.etap.2013.11.022","article-title":"Oral supplementation with troxerutin (trihydroxyethylrutin), modulates lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine-induced rat colon carcinogenesis","volume":"37","author":"Vinothkumara","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jpba.2017.12.018_bib0065","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00394-016-1275-0","article-title":"The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects","volume":"56","author":"Nisha Susan Thomas","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jpba.2017.12.018_bib0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biopha.2017.04.059","article-title":"Troxerutin (TXN) potentiated 5-Fluorouracil (5-Fu) treatment of human gastric cancer through suppressing STAT3\/NF-kB and Bcl-2 signaling pathways","volume":"92","author":"Xu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpba.2017.12.018_bib0075","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejphar.2015.11.023","article-title":"Involvement of AMPK\/SIRT1 pathway in anti-allodynic effect of troxerutin in CCI-induced neuropathic pain","volume":"769","author":"Gui","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"1-2","key":"10.1016\/j.jpba.2017.12.018_bib0080","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11010-015-2474-3","article-title":"Troxerutin reverses fibrotic changes in the myocardium of high fat high-fructose diet-fed mice","volume":"407","author":"Geetha","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.jpba.2017.12.018_bib0085","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.3892\/mmr.2017.6456","article-title":"Troxerutin protects against diabetic cardiomyopathy through NF-\u03baB\/AKT\/IRS1 in a rat model of type 2 diabetes","volume":"15","author":"Yu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jpba.2017.12.018_bib0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11010-005-8052-3","article-title":"Protection of cellular DNA from \u03b3-radiation-induced damages and enhancement in DNA repair by troxerutin","volume":"280","author":"Maurya","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jpba.2017.12.018_bib0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s10753-016-0462-8","article-title":"Troxerutin preconditioning and ischemic postconditioning modulate inflammatory response after myocardial Ischemia\/Reperfusion injury in rat model","volume":"40","author":"Badalzadeh","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.jpba.2017.12.018_bib0100","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1002\/rcm.2764","article-title":"Liquid chromatography\/tandem mass spectrometry assay for the quantification of troxerutin in human plasma","volume":"20","author":"Liu","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2017.12.018_bib0105","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jchromb.2007.06.002","article-title":"The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet\u2013visible detection","volume":"856","author":"Yang","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2017.12.018_bib0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10337-010-1827-z","article-title":"LC-MS\u2013MS determination of troxerutin plasma and its application to a pharmacokinetic study","volume":"73","author":"Cui","year":"2011","journal-title":"Chromatography"},{"key":"10.1016\/j.jpba.2017.12.018_bib0115","first-page":"333","article-title":"Reverse phase HPLC method development and validation for the simultaneous quantitative estimation of troxerutin and calcium dobesilate in tablets","volume":"6","author":"Hepsebah","year":"2014","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.jpba.2017.12.018_bib0120","first-page":"1681","article-title":"Hplc-separation and UV-spectral identification of O- (\u03b2-hydroxyethyl)-rutins","volume":"65","author":"Dimova","year":"2012","journal-title":"Compt. Rend. Acad. Bulg. Sci."},{"key":"10.1016\/j.jpba.2017.12.018_bib0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cclet.2009.08.017","article-title":"Ragioselective enzymatic acylation of troxerutin in nonaqueous medium","volume":"21","author":"Xiao","year":"2010","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpba.2017.12.018_bib0130","first-page":"438","article-title":"Separation of complexed semi-synthetic flavonoids by using fused core column in short time","volume":"8","author":"Ammar","year":"2016","journal-title":"J. Chem. Pharm. Res."},{"key":"10.1016\/j.jpba.2017.12.018_bib0135","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpba.2016.09.037","article-title":"Development and validation of a stability-indicating HPLC-UV method for the determination of thiocolchicoside and its degradation products","volume":"132","author":"Aprile","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2017.12.018_bib0140","unstructured":"ICH, Q1A (R2), Stability Testing of New Drug Substances and Products: Text and Methodology, International Conference on Harmonisation, Geneva, November 2005."},{"key":"10.1016\/j.jpba.2017.12.018_bib0145","unstructured":"ICH, Q2A (R1), Validation of Analytical Procedures: Text and Methodology, International Conference on Harmonisation, Geneva, November 2005."},{"key":"10.1016\/j.jpba.2017.12.018_bib0150","unstructured":"Center for Drug Evaluation and Research, U.S. Food and Drug Administration. Reviewer Guidance, Validation of Chromatographic Methods; FDA, Rockville, MD, November 1994."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517322744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517322744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T06:00:57Z","timestamp":1535176857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708517322744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":30,"alternative-id":["S0731708517322744"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2017.12.018","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2017.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}