{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:53:54Z","timestamp":1788954834965,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong province","doi-asserted-by":"crossref","award":["2016A020226031"],"award-info":[{"award-number":["2016A020226031"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong province","doi-asserted-by":"crossref","award":["2017A020213022"],"award-info":[{"award-number":["2017A020213022"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program of Science and Technology of Guangzhou","award":["201607010334"],"award-info":[{"award-number":["201607010334"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673565"],"award-info":[{"award-number":["81673565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270054"],"award-info":[{"award-number":["81270054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jpba.2018.02.037","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T17:36:10Z","timestamp":1519234570000},"page":"15-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Simultaneous qualitative and quantitative evaluation of Ilex kudingcha C. J. tseng by using UPLC and UHPLC-qTOF-MS\/MS"],"prefix":"10.1016","volume":"155","author":[{"given":"Jie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Xiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ying","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Juan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Jun","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9088-3959","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2018.02.037_bib0005","series-title":"Dictionary of Traditional Chinese Medicine","first-page":"1288","author":"Jiangsu New Medical College","year":"1986"},{"key":"10.1016\/j.jpba.2018.02.037_bib0010","first-page":"75","article-title":"Phytochemical constituents and pharmacological activities of Ilex kudingcha C.J. Tseng","volume":"15","author":"Che","year":"2017","journal-title":"Cent. South Pharm."},{"key":"10.1016\/j.jpba.2018.02.037_bib0015","first-page":"703","article-title":"Research progress on triterpenoids and pharmacology of Kudingcha","volume":"21","author":"Wang","year":"2016","journal-title":"Chin. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2018.02.037_bib0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.foodchem.2008.07.041","article-title":"Antioxidant activity and principles of Vietnam bitter tea Ilex kudingcha","volume":"113","author":"Thuong","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.02.037_bib0025","doi-asserted-by":"crossref","first-page":"e51007","DOI":"10.1371\/journal.pone.0051007","article-title":"Extract of Kuding tea prevents high-fat diet-induced metabolic disorders in C57BL\/6 mice via liver X receptor (LXR) \u03b2 antagonism","volume":"7","author":"Fan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2018.02.037_bib0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11418-013-0758-z","article-title":"The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities","volume":"67","author":"Li","year":"2013","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jpba.2018.02.037_bib0035","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3892\/mmr.2013.1635","article-title":"Anti-inflammatory effects of kudingcha methanol extract (Ilex Kudingcha C.J. Tseng) in dextran sulfate sodium-induced ulcerative colitis","volume":"8","author":"Song","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jpba.2018.02.037_bib0040","doi-asserted-by":"crossref","first-page":"423690","DOI":"10.1155\/2012\/423690","article-title":"Antidiabetic effect of an active components group from Ilex kudingcha and its chemical composition","volume":"2012","author":"Song","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jpba.2018.02.037_bib0045","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.3892\/ol.2013.1253","article-title":"Ilex kudingcha C.J. Tseng (Kudingcha) has in vitro anticancer activities in MCF-7 human breast adenocarcinoma cells and exerts anti-metastatic effects in vivo","volume":"5","author":"Zhao","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jpba.2018.02.037_bib0050","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3892\/etm.2013.1450","article-title":"In vitro and in vivo anti-cancer activities of Kuding tea (Ilex kudingcha C. J. Tseng) against oral cancer","volume":"7","author":"Zhu","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jpba.2018.02.037_bib0055","doi-asserted-by":"crossref","first-page":"223S","DOI":"10.1093\/ajcn\/81.1.223S","article-title":"Polyphenols in foods are more complex than often thought","volume":"81","author":"Cheynier","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jpba.2018.02.037_bib0060","doi-asserted-by":"crossref","first-page":"330S","DOI":"10.1093\/ajcn\/81.1.330S","article-title":"Polyphenols factors influencing their sensory properties and their effects on food and beverage preferences","volume":"81","author":"Lesschaeve","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jpba.2018.02.037_bib0065","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/10286020.2011.653347","article-title":"Two new triterpenoid saponins from the leaves of Ilex kudingcha","volume":"14","author":"Zuo","year":"2012","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jpba.2018.02.037_bib0070","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/10286020902937491","article-title":"Triterpene saponins from the leaves of Ilex kudingcha","volume":"11","author":"Tang","year":"2009","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jpba.2018.02.037_bib0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.foodchem.2008.05.038","article-title":"Determination of polyphenolic content and antioxidant activity of kudingcha made from Ilex kudingcha C.J. Tseng","volume":"112","author":"Liu","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.02.037_bib0080","first-page":"119","article-title":"Purification and HPLC analysis of caffeoylquinic acids from Kudingcha made from Ilex kudingcha C.J Tseng","volume":"34","author":"Wang","year":"2013","journal-title":"Food Sci."},{"key":"10.1016\/j.jpba.2018.02.037_bib0085","first-page":"109","article-title":"The determination of rutin and flavonoids of Kudingcha Leaves","volume":"30","author":"Yin","year":"2009","journal-title":"J. Food Res. Dev."},{"key":"10.1016\/j.jpba.2018.02.037_bib0090","first-page":"383","article-title":"Determination of quertetin and kaempferol in theburgeon leaves and old leaves of Guangxi Kudingcha","volume":"22","author":"Huang","year":"2005","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"10.1016\/j.jpba.2018.02.037_bib0095","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/pca.2372","article-title":"Quantitative analysis of five kudinosides in the large-leaved Kudingcha and related species from the genus Ilex by UPLC-ELSD","volume":"23","author":"Li","year":"2012","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jpba.2018.02.037_bib0100","first-page":"41","article-title":"HPLC determination of ursolic acid and oleanolic acid in Ilex Kudingcha C.J. Tseng","volume":"28","author":"Li","year":"2010","journal-title":"Guizhou Sci."},{"key":"10.1016\/j.jpba.2018.02.037_bib0105","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00280-003-0746-1","article-title":"Interactions of a herbal combination that inhibits growth of prostate cancer cells","volume":"53","author":"Chung","year":"2004","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jpba.2018.02.037_bib0110","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/jssc.201400362","article-title":"Fingerprint analysis and multi-ingredient quantitative analysis for quality evaluation of Xiaoyanlidan tablets by ultra high performance liquid chromatography with diode array detection","volume":"37","author":"Tang","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2018.02.037_bib0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpba.2013.05.039","article-title":"Multi-ingredients determination and fingerprint analysis of leaves from Ilex latifolia using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry","volume":"84","author":"Fan","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.02.037_bib0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.talanta.2015.09.039","article-title":"A strategy for comprehensive identification of sequential constituents using ultra-high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometer: application study on chlorogenic acids in Flos Lonicerae Japonicae","volume":"147","author":"Zhang","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2018.02.037_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.talanta.2012.11.012","article-title":"Diagnostic fragment-ion-based and extension strategy coupled to DFIs intensity analysis for identification of chlorogenic acids isomers in Flos Lonicerae Japonicae by HPLC-ESI-MS(n)","volume":"104","author":"Zhang","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2018.02.037_bib0130","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jfda.2013.05.012","article-title":"Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations","volume":"21","author":"Liu","year":"2013","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jpba.2018.02.037_bib0135","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1007\/s12161-014-9821-y","article-title":"Analysis of essential oils from Cassia Bark and Cassia Twig samples by GC\u2013MS combined with multivariate date analysis","volume":"7","author":"Deng","year":"2014","journal-title":"Food Anal. Methods"},{"key":"10.1016\/j.jpba.2018.02.037_bib0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.foodchem.2016.02.131","article-title":"Rapid direct analysis to discriminate geographic origin of extra virgin olive oils by flash gas chromatography electronic nose and chemometrics","volume":"204","author":"Melucci","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.02.037_bib0145","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.foodchem.2016.04.134","article-title":"The current practice in the application of chemometrics for correlation of sensory and gas chromatographic data","volume":"210","author":"Seisonen","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.02.037_bib0150","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jpba.2011.03.021","article-title":"HPLC-DAD-MSn analysis and HPLC quantitation of chemical constituents in Xian-ling-gu-bao capsules","volume":"55","author":"Guan","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.02.037_bib0155","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.foodchem.2010.12.014","article-title":"Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species","volume":"126","author":"Li","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.02.037_bib0160","series-title":"Studies on Chemical Constituents and Antiplatelet Aggregation Activity in Vitro of Ilex kudingcha","author":"Yang","year":"2015"},{"key":"10.1016\/j.jpba.2018.02.037_bib0165","series-title":"Purification of Caffeolyquinic Acid from Ilex kudingcha C.J. Tseng and the Study of Their Anti-Obesity Efficacy","author":"Wang","year":"2004"},{"key":"10.1016\/j.jpba.2018.02.037_bib0170","series-title":"Study on Isolation and Identification of Ilex Latifolia Thunb and Its Bioactivities","author":"Hu","year":"2013"},{"key":"10.1016\/j.jpba.2018.02.037_bib0175","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jpba.2013.08.049","article-title":"A single multi-faceted, enhanced strategy to quantify the chromatographically diverse constituents in the roots of Euphorbia kansui","volume":"88","author":"Hou","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.02.037_bib0180","first-page":"1","article-title":"Simultaneous determination of nine flavonoids in Dalbergia odorifera by LC","volume":"4","author":"Liu","year":"2005","journal-title":"Chromatogra"},{"key":"10.1016\/j.jpba.2018.02.037_bib0185","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/chromsci\/bmu155","article-title":"Rapid characterization and identification of flavonoids in Radix Astragali by ultra-high-pressure liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry","volume":"53","author":"Zhang","year":"2015","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jpba.2018.02.037_bib0190","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jpha.2011.09.009","article-title":"Characterization of flavonoids in Millettia nitida var. hirsutissima by HPLC\/DAD\/ESI\u2013MS","volume":"2","author":"Ye","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.02.037_bib0195","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpba.2016.09.027","article-title":"Simultaneous determination of phenolic acids and flavonoids in Chenopodium formosanum Koidz. (djulis) by HPLC-DAD-ESI-MS\/MS","volume":"132","author":"Hsu","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.02.037_bib0200","first-page":"36","article-title":"Identification of saponins from sugar beet (Beta vulgaris) by low and high-resolution HPLC-MS\/MS: J","volume":"1029","author":"Katarzyna","year":"2016","journal-title":"Chromatogr. B Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2018.02.037_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.talanta.2012.11.012","article-title":"Diagnostic fragment-ion-based and extentsion strategy coupled to DFIs intensity analysis for identification of chlorogenic acids isomers in Flos Lonicerae Japonicae by HPLC-ESI\u2013MSn","volume":"104","author":"Zhang","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2018.02.037_bib0210","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jms.600","article-title":"Mass spectrometry of 1,3- and 1,5-dicaffeoylquinic acids","volume":"139","author":"Schram","year":"2004","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2018.02.037_bib0215","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3390\/molecules21121728","article-title":"Simultaneous qualitation and quantitation of chlorogenic acids in Kuding tea using ultra-high-performance liquid chromatography-diode array detection coupled with linear ion trap-orbitrap mass spectrometer","volume":"21","author":"Che","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2018.02.037_bib0220","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/rcm.7151","article-title":"Differentiation of prototropic ions in regioisomeric caffeoyl quinic acids by electrospray ion mobility mass spectrometry","volume":"29","author":"Kuhnert","year":"2015","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2018.02.037_bib0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jep.2015.01.006","article-title":"Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC-MS method","volume":"163","author":"Yuan","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2018.02.037_bib0230","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chroma.2003.11.086","article-title":"Characterisation of beeswax in works of art by gas chromatography-mass spectrometry and pyrolysis-gas chromatography-mass spectrometry procedures","volume":"1028","author":"Bonaduce","year":"2004","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517318654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517318654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T01:39:57Z","timestamp":1589852397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708517318654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":46,"alternative-id":["S0731708517318654"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.02.037","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous qualitative and quantitative evaluation of Ilex kudingcha C. J. tseng by using UPLC and UHPLC-qTOF-MS\/MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.02.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}