{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:15:33Z","timestamp":1779891333826,"version":"3.53.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"T\u00dcB\u0130TAK"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jpba.2018.03.016","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T13:31:22Z","timestamp":1520861482000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["A novel silanization agent based single used biosensing system: Detection of C-reactive protein as a potential Alzheimer\u2019s disease blood biomarker"],"prefix":"10.1016","volume":"154","author":[{"given":"M\u00fcnteha Nur","family":"Sonu\u00e7 Karabo\u011fa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Kemal","family":"Sezgint\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jpba.2018.03.016_bib0005","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.clim.2005.08.004","article-title":"C-reactive protein: ligands, receptors and role in inflammation","volume":"117","author":"Marnell","year":"2005","journal-title":"Clin. Immunol."},{"issue":"2","key":"10.1016\/j.jpba.2018.03.016_bib0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/HYPERTENSIONAHA.110.165837","article-title":"C-reactive protein: just a biomarker of inflammation or a pathophysiological player in myocardial function and morphology","volume":"57","author":"Schulz","year":"2011","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.jpba.2018.03.016_bib0015","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neulet.2009.09.035","article-title":"Sialic acid, homocysteine and CRP: potential markers for dementia","volume":"465","author":"Davis","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.jpba.2018.03.016_bib0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.biocel.2004.07.009","article-title":"The role of inflammation in Alzheimer\u2019s disease","volume":"37","author":"Tuppo","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.jpba.2018.03.016_bib0025","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jalz.2009.04.1230","article-title":"Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old","volume":"5","author":"Kravitz","year":"2009","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.jpba.2018.03.016_bib0030","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0197-4580(01)00288-3","article-title":"The pentraxins: possible role in Alzheimer\u2019s disease and other innate inflammatory diseases","volume":"22","author":"McGeer","year":"2001","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.jpba.2018.03.016_bib0035","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0006-8993(00)02970-X","article-title":"Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer\u2019s disease","volume":"887","author":"Yasojima","year":"2000","journal-title":"Brain Res."},{"issue":"11","key":"10.1016\/j.jpba.2018.03.016_bib0040","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1093\/jn\/134.11.3127","article-title":"Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique","volume":"134","author":"Erhardt","year":"2004","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.jpba.2018.03.016_bib0045","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bbi.2010.12.020","article-title":"Validation of a high-sensitivity assay for C-reactive protein in human saliva","volume":"25","author":"Ouellet-Morin","year":"2011","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.jpba.2018.03.016_bib0050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1039\/b414194f","article-title":"Application of microchip assay system for the measurement of C-reactive protein in human saliva","volume":"5","author":"Christodoulides","year":"2005","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.jpba.2018.03.016_bib0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1479-5876-10-24","article-title":"Sensitive and rapid quantification of C-reactive protein using quantum dot-labeled microplate immunoassay","volume":"10","author":"Luo","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jpba.2018.03.016_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2012.09.007","article-title":"Current analytical strategies for C-reactive protein quantification in blood","volume":"415","author":"Algarra","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jpba.2018.03.016_bib0065","doi-asserted-by":"crossref","first-page":"36708","DOI":"10.1038\/srep36708","article-title":"Multifunctional indium tin oxide electrode generated by unusual surface modification","volume":"6","author":"Bouden","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jpba.2018.03.016_bib0070","doi-asserted-by":"crossref","first-page":"1170097","DOI":"10.1080\/23311916.2016.1170097","article-title":"Effect of ITO surface properties on SAM modification: a review toward biosensor application","volume":"3","author":"Khan","year":"2016","journal-title":"Cogent. Eng."},{"issue":"8","key":"10.1016\/j.jpba.2018.03.016_bib0075","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1021\/ac052037d","article-title":"On-chip amperometric measurement of quantal catecholamine release using transparent indium tin oxide electrodes","volume":"78","author":"Sun","year":"2006","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.jpba.2018.03.016_bib0080","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.solmat.2009.01.015","article-title":"Characteristics of flexible indium tin oxide electrode grown by continuous roll-to-roll sputtering process for flexible organic solar cells","volume":"93","author":"Choi","year":"2009","journal-title":"Sol. Energy Mater. Sol. Cells."},{"issue":"19","key":"10.1016\/j.jpba.2018.03.016_bib0085","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1039\/C6AN00694A","article-title":"Label-free, ITO-based immunosensor for the detection of a cancer biomarker: receptor for activated C Kinase 1","volume":"141","author":"Bahad\u0131r","year":"2016","journal-title":"Analyst"},{"issue":"4","key":"10.1016\/j.jpba.2018.03.016_bib0090","first-page":"199","article-title":"Organofunctional silanes \u2013 functions, applications and advantages","volume":"11","author":"Marsden","year":"1979","journal-title":"Polym. Int."},{"key":"10.1016\/j.jpba.2018.03.016_bib0095","series-title":"Bioconjugate Techniques","author":"Hermanson","year":"2013"},{"issue":"1","key":"10.1016\/j.jpba.2018.03.016_bib0100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10971-013-3057-y","article-title":"Preparation and characterization of new sol\u2013gel titanium (IV) butoxide\u2013cyanopropyltriethoxysilane hybrid sorbent for extraction of polar aromatic amines","volume":"67","author":"Miskam","year":"2013","journal-title":"J. Sol-Gel Sci. Technol."},{"issue":"2","key":"10.1016\/j.jpba.2018.03.016_bib0105","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1163\/156856192X00359","article-title":"Organofunctional silanes as adhesion promoters: direct characterization of the polymer\/silane interphase","volume":"6","author":"Gentle","year":"1992","journal-title":"J. Adhes. Sci. Technol."},{"issue":"8","key":"10.1016\/j.jpba.2018.03.016_bib0110","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1163\/156856102760146165","article-title":"Kinetics of cure, cross link density and adhesion of water-reactive alkoxysilicone sealants","volume":"16","author":"De Buyl","year":"2002","journal-title":"J. Adhes. Sci. Technol."},{"issue":"6","key":"10.1016\/j.jpba.2018.03.016_bib0115","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1039\/b920491a","article-title":"Chemical modification of self-assembled silane based monolayers by surface reactions","volume":"39","author":"Haensch","year":"2010","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.jpba.2018.03.016_bib0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-291X(76)91101-3","article-title":"Immobilization of enzymes by covalent binding to amine supports via cyanogen bromide activation","volume":"70","author":"Schnapp","year":"1976","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jpba.2018.03.016_bib0125","series-title":"Compendium of Chemical Terminology","author":"McNaught","year":"1997"},{"key":"10.1016\/j.jpba.2018.03.016_bib0130","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bioelechem.2015.10.002","article-title":"Label-free and direct detection of C-reactive protein using reduced graphene oxide-nanoparticle hybrid impedimetric sensor","volume":"107","author":"Yagati","year":"2016","journal-title":"Bioelectrochemistry"},{"issue":"11","key":"10.1016\/j.jpba.2018.03.016_bib0135","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/elan.200804560","article-title":"Detection of C reactive protein (CRP) in serum by an electrochemical aptamer-based sandwich assay","volume":"21","author":"Centi","year":"2009","journal-title":"Electroanalysis"},{"key":"10.1016\/j.jpba.2018.03.016_bib0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.snb.2014.10.012","article-title":"Development of a sensitive SPR biosensor for C-reactive protein (CRP) using plasma-treated parylene-N film","volume":"207","author":"Choi","year":"2015","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.jpba.2018.03.016_bib0145","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bios.2014.03.027","article-title":"Label-free detection of C-reactive protein using a carbon nanofiber based biosensor","volume":"59","author":"Gupta","year":"2014","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.jpba.2018.03.016_bib0150","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1745-7270.2007.00320.x","article-title":"Fourier transform infrared spectroscopic analysis of protein secondary structures","volume":"39","author":"Kong","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517323117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708517323117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T01:48:37Z","timestamp":1549331317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708517323117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":30,"alternative-id":["S0731708517323117"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.03.016","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel silanization agent based single used biosensing system: Detection of C-reactive protein as a potential Alzheimer\u2019s disease blood biomarker","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}