{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:59:39Z","timestamp":1786993179987,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["PUE IQUIR 2016"],"award-info":[{"award-number":["PUE IQUIR 2016"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"crossref","award":["PICT 2014-0445"],"award-info":[{"award-number":["PICT 2014-0445"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jpba.2018.06.019","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T19:08:04Z","timestamp":1529348884000},"page":"461-470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Chemometrics-assisted study of the interconversion between the crystalline forms of nimodipine"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1099-3686","authenticated-orcid":false,"given":"Natalia L.","family":"Calvo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-8618","authenticated-orcid":false,"given":"Naira M.","family":"Balzaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodoro S.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n M.","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2018.06.019_bib0005","series-title":"Polymorphism in Pharmaceutical Solids","author":"Brittain","year":"2009"},{"key":"10.1016\/j.jpba.2018.06.019_bib0010","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.4155\/tde.14.68","article-title":"Understanding pharmaceutical polymorphic transformations I: influence of process variables and storage conditions","volume":"5","author":"Sood","year":"2014","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.jpba.2018.06.019_bib0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.supflu.2015.08.021","article-title":"Enantiomeric separation of 1,4-dihydropyridines by liquid-phase microextraction with supercritical fluid chromatography","volume":"107","author":"Zhang","year":"2016","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jpba.2018.06.019_bib0020","series-title":"Division of Bioequivalence Review","article-title":"Bioequivalence reviews: ANDA 76","author":"Nguyen","year":"2004"},{"key":"10.1016\/j.jpba.2018.06.019_bib0025","series-title":"Martindale: The Complete Drug Reference","first-page":"1357","article-title":"Nimodipine","author":"Sweetman","year":"2009"},{"key":"10.1016\/j.jpba.2018.06.019_bib0030","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1208\/s12249-011-9628-8","article-title":"A kinetic study of the polymorphic transformation of nimodipine and indomethacin during high shear granulation","volume":"12","author":"Guo","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpba.2018.06.019_bib0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0378-5173(94)00284-C","article-title":"Polymorphism in binary mixtures, as exemplified by nimodipine","volume":"118","author":"Grunenberg","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0040","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1208\/aapsj080471","article-title":"Effect of physical state and particle size distribution on dissolution enhancement of nimodipine\/PEG solid dispersions prepared by melt mixing and solvent evaporation","volume":"8","author":"Papageorgiou","year":"2006","journal-title":"AAPS J."},{"key":"10.1016\/j.jpba.2018.06.019_bib0045","first-page":"1871","article-title":"Study on influencing factors of chemical stability of nimodipine polymorphs","volume":"40","author":"Yuan","year":"2005","journal-title":"Chin. Pharm. J."},{"key":"10.1016\/j.jpba.2018.06.019_bib0050","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/03639040500216212","article-title":"Physical-chemical characterization and polymorphism determination of two nimodipine samples deriving from distinct laboratories","volume":"31","author":"Mazon Cardoso","year":"2005","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0055","first-page":"25","article-title":"Variability of nimodipine pharmacokinetics in healthy Chinese males","volume":"10","author":"Liu","year":"1996","journal-title":"Chin. J. Pharmacol. Toxicol."},{"key":"10.1016\/j.jpba.2018.06.019_bib0060","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1002\/jps.23712","article-title":"Chemometric evaluation of near infrared, Fourier transform infrared, and Raman spectroscopic models for the prediction of nimodipine polymorphs","volume":"102","author":"Siddiqui","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2018.06.019_bib0065","series-title":"Food and Drug Administration","author":"Nimodipine Capsule Recall","year":"2013"},{"key":"10.1016\/j.jpba.2018.06.019_bib0070","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1002\/jps.21204","article-title":"Detecting and identifying the complexation of nimodipine with hydroxypropyl-\u03b2-cyclodextrin present in tablets by Raman spectroscopy","volume":"97","author":"Yang","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2018.06.019_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2014.01.020","article-title":"In vitro dissolution enhancement of micronized l-nimodipine by antisolvent re-crystallization from its crystal form H","volume":"464","author":"Zu","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0080","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejpb.2004.08.005","article-title":"Solid dispersions of nimodipine and polyethylene glycol 2000: dissolution properties and physico-chemical characterization","volume":"59","author":"Urbanetz","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0085","first-page":"2857","article-title":"Physicochemical characterization and in vitro evaluation of solid dispersions of nimodipine with PEG 8000","volume":"23","author":"Gorajana","year":"2011","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.jpba.2018.06.019_bib0090","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s10973-008-9225-6","article-title":"The effect of physical state on the drug dissolution rate miscibility studies of nimodipine with PVP","volume":"95","author":"Papageorgiou","year":"2009","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.jpba.2018.06.019_bib0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.powtec.2015.03.029","article-title":"Enhanced hypotensive effect of nimodipine solid dispersions produced by supercritical CO2 drying","volume":"278","author":"Kl\u00fcppel Riekes","year":"2015","journal-title":"Powder Technol."},{"key":"10.1016\/j.jpba.2018.06.019_bib0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12272-015-0685-5","article-title":"Formulation of nimodipine nanocrystals for oral administration","volume":"39","author":"Li","year":"2016","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jpba.2018.06.019_bib0105","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ejps.2003.11.009","article-title":"Development of a dissolution medium for nimodipine tablets based on bioavailability evaluation","volume":"21","author":"He","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2018.06.019_bib0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2478\/s11532-014-0511-9","article-title":"Development and validation of an intrinsic dissolution method for nimodipine polymorphs","volume":"12","author":"Riekes","year":"2014","journal-title":"Cent. Eur. J. Chem."},{"key":"10.1016\/j.jpba.2018.06.019_bib0115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijpharm.2012.02.022","article-title":"Relationship between dissolution and bioavailability for nimodipine colloidal dispersions: the critical size in improving bioavailability","volume":"427","author":"Fu","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0120","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1208\/aapsj0903043","article-title":"Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder X-ray diffraction","volume":"9","author":"Docoslis","year":"2007","journal-title":"AAPS J."},{"key":"10.1016\/j.jpba.2018.06.019_bib0125","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jpba.2012.06.029","article-title":"Polymorphism in nimodipine raw materials: development and validation of a quantitative method through differential scanning calorimetry","volume":"70","author":"Riekes","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.06.019_bib0130","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3109\/03639045.2014.922571","article-title":"Application of chemometric methods to differential scanning calorimeter (DSC) to estimate nimodipine polymorphs from cosolvent system","volume":"41","author":"Siddiqui","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0135","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1208\/s12249-015-0327-8","article-title":"Comparison of univariate and multivariate models of 13C ssNMR and XRPD techniques for quantification of nimodipine polymorphs","volume":"16","author":"Rahman","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpba.2018.06.019_bib0140","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jpba.2017.06.017","article-title":"Characterization of pharmaceutically relevant materials at the solid state employing chemometrics methods","volume":"147","author":"Calvo","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.06.019_bib0145","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jpba.2017.06.018","article-title":"Chemometrics-assisted solid-state characterization of pharmaceutically relevant materials. Polymorphic substances","volume":"147","author":"Calvo","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.06.019_bib0150","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1208\/s12249-016-0659-z","article-title":"Albendazole microcrystal formulations based on chitosan and cellulose derivatives: physicochemical characterization and in vitro parasiticidal activity in Trichinella spiralis adult worms","volume":"18","author":"Priotti","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpba.2018.06.019_bib0155","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejpb.2010.09.017","article-title":"Solid dispersions in the development of a nimodipine floating tablet formulation and optimization by artificial neural networks and genetic programming","volume":"77","author":"Barmpalexis","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0160","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejps.2016.01.024","article-title":"In search of the mutual relationship between the structure, solid-state spectroscopy and molecular dynamics in selected calcium channel blockers","volume":"85","author":"Dru\u017cbicki","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2018.06.019_bib0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1208\/pt030212","article-title":"In vivo evaluation of modified gum karaya as a carrier for improving the oral bioavailability of a poorly water-soluble drug, nimodipine","volume":"3","author":"Mohan Babu","year":"2002","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpba.2018.06.019_bib0170","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/S0142-9612(03)00021-8","article-title":"Preparation and drug release behaviors of nimodipine-loaded poly(caprolactone)-poly(ethylene oxide)-polylactide amphiphilic copolymer nanoparticles","volume":"24","author":"Hu","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpba.2018.06.019_bib0175","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1023\/A:1015147729564","article-title":"A spectroscopic investigation of hydrogen bond patterns in crystalline and amorphous phases in dihydropyridine calcium channel blockers","volume":"19","author":"Tang","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jpba.2018.06.019_bib0180","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/03639040601050213","article-title":"Part I: characterization of solid dispersions of nimodipine prepared by hot-melt extrusion","volume":"33","author":"Zheng","year":"2013","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jpba.2018.06.019_bib0185","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/716242","article-title":"Nanoencapsulation of nimodipine in novel biocompatible poly(propylene-co-butylene succinate) aliphatic copolyesters for sustained release","author":"Papadimitriou","year":"2009","journal-title":"J. Nanomater."},{"key":"10.1016\/j.jpba.2018.06.019_bib0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.chemolab.2004.12.007","article-title":"A graphical user-friendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB","volume":"76","author":"Jaumot","year":"2005","journal-title":"Chemom. Intell. Lab. Syst."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518304564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518304564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T13:49:39Z","timestamp":1589896179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708518304564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":38,"alternative-id":["S0731708518304564"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.06.019","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemometrics-assisted study of the interconversion between the crystalline forms of nimodipine","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}