{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:27:11Z","timestamp":1780630031605,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773872"],"award-info":[{"award-number":["81773872"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673568"],"award-info":[{"award-number":["81673568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403057"],"award-info":[{"award-number":["81403057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ15H280002"],"award-info":[{"award-number":["LQ15H280002"]}]},{"name":"Shenzhen Key Laboratory of Hospital Chinese Medicine Preparation","award":["ZDSYS201606081515458"],"award-info":[{"award-number":["ZDSYS201606081515458"]}]},{"name":"priority academic program development of Jiangsu higher education institutions (PAPD)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jpba.2018.08.057","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T12:34:27Z","timestamp":1535805267000},"page":"336-343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["A chemical derivatization based UHPLC-LTQ-Orbitrap mass spectrometry method for accurate quantification of short-chain fatty acids in bronchoalveolar lavage fluid of asthma mice"],"prefix":"10.1016","volume":"161","author":[{"given":"Ying-Ying","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Qi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Xiu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Qun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Zhong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2018.08.057_bib0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12934-017-0691-z","article-title":"Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria","volume":"16","author":"LeBlanc","year":"2017","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.jpba.2018.08.057_bib0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.3444","article-title":"Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis","volume":"20","author":"Trompette","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.jpba.2018.08.057_bib0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1165\/rcmb.2015-0250PS","article-title":"The gut-liver-lung axis. Modulation of the innate immune response and its possible role in chronic obstructive pulmonary disease","volume":"54","author":"Young","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/1040841X.2016.1176988","article-title":"Gut-lung axis: the microbial contributions and clinical implications","volume":"43","author":"He","year":"2017","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrmicro.2017.14","article-title":"The microbiota of the respiratory tract: gatekeeper to respiratory health","volume":"15","author":"Man","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-immunol-020711-075021","article-title":"Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology","volume":"30","author":"Lambrecht","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0040","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/ajrccm.154.3.8810593","article-title":"Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome","volume":"154","author":"Goodman","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jpba.2018.08.057_bib0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jep.2017.06.016","article-title":"Pulvis Fellis Suis extract attenuates ovalbumin-induced airway inflammation in murine model of asthma","volume":"207","author":"He","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3109\/17435390.2015.1104740","article-title":"Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles","volume":"10","author":"Morimoto","year":"2016","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.jpba.2018.08.057_bib0055","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3389\/fimmu.2017.00658","article-title":"A combination of Podophyllotoxin and rutin alleviates radiation-induced pneumonitis and fibrosis through modulation of lung inflammation in mice","volume":"8","author":"Verma","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0060","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1021\/pr5002059","article-title":"Novel approach for analysis of bronchoalveolar lavage fluid (BALF) using HPLC-QTOF-MS-based lipidomics: lipid levels in asthmatics and corticosteroid-treated asthmatic patients","volume":"13","author":"Kang","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2018.08.057_bib0065","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1021\/pr4007624","article-title":"Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health","volume":"13","author":"Evans","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2018.08.057_bib0070","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1021\/pr5003615","article-title":"Metabolomics reveals inflammatory-linked pulmonary metabolic alterations in a murine model of house dust mite-induced allergic asthma","volume":"13","author":"Ho","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2018.08.057_bib0075","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1021\/acs.analchem.5b00732","article-title":"Profiling over 1500 lipids in induced lung sputum and the implications in studying lung diseases","volume":"87","author":"t\u2019Kindt","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2018.08.057_bib0080","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1021\/pr900738b","article-title":"Multiorigination of chromatographic peaks in derivatized GC\/MS metabolomics: a confounder that influences metabolic pathway interpretation","volume":"12","author":"Xu","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2018.08.057_bib0085","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/cei.12346","article-title":"Vitamin D binding protein and vitamin D in human allergen-induced endobronchial inflammation","volume":"177","author":"Bratke","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0090","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1039\/C6FO01406B","article-title":"Dietary fibers influence the intestinal SCFAs and plasma metabolites profiling in growing pigs","volume":"7","author":"Wu","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.jpba.2018.08.057_bib0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.aca.2004.02.054","article-title":"Rapid measurement of 13C-enrichment of acetic, propionic and butyric acids in plasma with solid phase microextraction coupled to gas chromatography-mass spectrometry","volume":"512","author":"Moreau","year":"2004","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2018.08.057_bib0100","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s11306-013-0500-6","article-title":"A targeted metabolomic protocol for short-chain fatty acids and branched-chain amino acids","volume":"9","author":"Zheng","year":"2013","journal-title":"Metabolomics."},{"key":"10.1016\/j.jpba.2018.08.057_bib0105","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.aca.2014.11.015","article-title":"An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography-tandem mass spectrometry","volume":"854","author":"Han","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2018.08.057_bib0110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cca.2017.02.016","article-title":"Application of packed-fiber solid-phase extraction coupled with GC-MS for the determination of short-chain fatty acids in children\u2019s urine","volume":"468","author":"Zhao","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jpba.2018.08.057_bib0115","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jpba.2016.04.033","article-title":"Isotope-coded ESI-enhancing derivatization reagents for differential analysis, quantification and profiling of metabolites in biological samples by LC\/MS: a review","volume":"130","author":"Higashi","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.08.057_bib0120","first-page":"1","article-title":"Ion traps in modern mass spectrometry","author":"Nolting","year":"2017","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.jpba.2018.08.057_bib0125","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.aca.2016.10.043","article-title":"An in vitro approach for lipolysis measurement using high-resolution mass spectrometry and partial least squares based analysis","volume":"950","author":"Chang","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2018.08.057_bib0130","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jpba.2017.07.054","article-title":"Comparison of three officinal species of Callicarpa based on a biochemome profiling strategy with UHPLC-IT-MS and chemometrics analysis","volume":"145","author":"Chen","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.08.057_bib0135","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ab.2008.07.010","article-title":"Quantitative metabolome analysis using liquid chromatography-high-resolution mass spectrometry","volume":"382","author":"Kiefer","year":"2008","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jpba.2018.08.057_bib0140","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0300-9629(96)00328-3","article-title":"In vitro studies on transport and metabolism of short-chain fatty acids in pig hindgut","volume":"118","author":"Breves","year":"1997","journal-title":"Comp. Biochem. Physiol. A Physiol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0145","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1021\/ac500472c","article-title":"Quantification and mass isotopomer profiling of \u03b1-keto acids in central carbon metabolism","volume":"86","author":"Zimmermann","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2018.08.057_bib0150","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jpba.2007.04.001","article-title":"Quantification of 13C pyruvate and 13C lactate in dog blood by reversed-phase liquid chromatography-electrospray ionization mass spectrometry after derivatization with 3-nitrophenylhydrazine","volume":"44","author":"Uran","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.08.057_bib0155","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/elps.201600150","article-title":"Quantitation of low molecular weight sugars by chemical derivatization-liquid chromatography\/multiple reaction monitoring\/mass spectrometry","volume":"37","author":"Han","year":"2016","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jpba.2018.08.057_bib0160","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.5740\/jaoac.int.2015.04","article-title":"Determination of Monofluoroacetate in powdered nutritional products by derivatization with 2-Nitrophenylhydrazine and LC-MS\/MS: first action 2015.04","volume":"98","author":"Reddy","year":"2015","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.jpba.2018.08.057_bib0165","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jasms.2006.03.006","article-title":"Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer","volume":"17","author":"Makarov","year":"2006","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jpba.2018.08.057_bib0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17060816","article-title":"Applications of fourier transform ion cyclotron resonance (FT-ICR) and orbitrap based high resolution mass spectrometry in Metabolomics and lipidomics","volume":"17","author":"Ghaste","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2018.08.057_bib0175","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/imr.12556","article-title":"The nutrition-gut microbiome-physiology axis and allergic diseases","volume":"278","author":"McKenzie","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jpba.2018.08.057_bib0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrmicro.2016.142","article-title":"Emerging pathogenic links between microbiota and the gut-lung axis","volume":"15","author":"Budden","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jpba.2018.08.057_bib0185","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1002\/1873-3468.12421","article-title":"Linking microbiota and respiratory disease","volume":"590","author":"Hauptmann","year":"2016","journal-title":"FEBS Lett."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518311233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518311233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:53:18Z","timestamp":1759999998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708518311233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":37,"alternative-id":["S0731708518311233"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.08.057","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A chemical derivatization based UHPLC-LTQ-Orbitrap mass spectrometry method for accurate quantification of short-chain fatty acids in bronchoalveolar lavage fluid of asthma mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.08.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}