{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:05:49Z","timestamp":1762272349470,"version":"3.37.3"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81673532"],"award-info":[{"award-number":["81673532"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Support Program of China","award":["2011BAI04B03"],"award-info":[{"award-number":["2011BAI04B03"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jpba.2018.09.053","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T23:37:00Z","timestamp":1538177820000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Interactions of pharmacokinetic profiles of Ginkgotoxin and Ginkgolic acids in rat plasma after oral administration"],"prefix":"10.1016","volume":"163","author":[{"given":"Yiyun","family":"Qian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-ao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2003","series-title":"Compendium of materia medica: bencao gangmu","author":"Luo","key":"10.1016\/j.jpba.2018.09.053_bib0005"},{"issue":"4","key":"10.1016\/j.jpba.2018.09.053_bib0010","first-page":"461","article-title":"Experience of 62 cases of emergency treatment of acute poisoning of Ginkgo","volume":"8","author":"Chuan","year":"2010","journal-title":"Clin. Educ. Gen. Pract."},{"issue":"6","key":"10.1016\/j.jpba.2018.09.053_bib0015","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/ageing\/30.6.523","article-title":"Ginkgo biloba precipitating epileptic seizures","volume":"30","author":"Granger","year":"2001","journal-title":"Age Ageing"},{"issue":"5","key":"10.1016\/j.jpba.2018.09.053_bib0020","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1248\/cpb.36.1779","article-title":"Studies on the constitution of edible and medicinal plants. I. Isolation and identification of 4-O-methylpyridoxine, toxic principle from the seed of Ginkgo biloba L","volume":"36","author":"Wada","year":"1988","journal-title":"Chem. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.jpba.2018.09.053_bib0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.14581\/jer.15018","article-title":"Ginkgotoxin induced seizure caused by vitamin B6 deficiency","volume":"5","author":"Jang","year":"2015","journal-title":"J. Epilepsy Res."},{"issue":"1","key":"10.1016\/j.jpba.2018.09.053_bib0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0006-8993(76)90934-3","article-title":"Differential decrease of GABA in the substantia nigra and other discrete regions of the rabbit brain during the preictal period of methoxypyridoxine-induced seizures","volume":"105","author":"Nitsch","year":"1976","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.jpba.2018.09.053_bib0035","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1742-4658.2007.05654.x","article-title":"The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba","volume":"274","author":"Kastner","year":"2007","journal-title":"FEBS J."},{"issue":"7","key":"10.1016\/j.jpba.2018.09.053_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040954","article-title":"Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition","volume":"7","author":"Gandhi","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jpba.2018.09.053_bib0045","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.nutres.2015.05.015","article-title":"Decrease in pyridoxal-5\u2019-phosphate concentration and increase in pyridoxal concentration in rat plasma by 4\u2019-O-methylpyridoxine administration","volume":"35","author":"Kobayashi","year":"2015","journal-title":"Nutr. Res."},{"issue":"4","key":"10.1016\/j.jpba.2018.09.053_bib0050","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1248\/bpb.27.486","article-title":"Rapid analysis of 4-O-methylpyridoxine in the serum of patients with Ginkgo biloba seed poisoning by ion-pair high-performance liquid chromatography","volume":"27","author":"Hori","year":"2004","journal-title":"Biol. Pharm. Bull."},{"issue":"11","key":"10.1016\/j.jpba.2018.09.053_bib0055","article-title":"Study on a toxic component-ginkgolic acids in teas of Ginkgo biloba","volume":"31","author":"Wu","year":"2003","journal-title":"Chin. J. Anal. Chem."},{"issue":"10","key":"10.1016\/j.jpba.2018.09.053_bib0060","first-page":"735","article-title":"Chemistry and biology of alkylphenols from Ginkgo biloba L","volume":"52","author":"Jaggy","year":"1997","journal-title":"Die Pharmazie"},{"key":"10.1016\/j.jpba.2018.09.053_bib0065","first-page":"85","article-title":"Simultaneous quantification and semi-quantification of ginkgolic acids and their metabolites in rat plasma by UHPLC\u2013LTQ\u2013Orbitrap\u2013MS and its application to pharmacokinetics study","volume":"1041\u20131042","author":"Qian","year":"2016","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2018.09.053_bib0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chroma.2014.04.090","article-title":"Identification and quantification of the main isoflavones and other phytochemicals in soy based nutraceutical products by liquid chromatography-orbitrap high resolution mass spectrometry","volume":"1348","author":"Lopez-Gutierrez","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2018.09.053_bib0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chroma.2013.12.067","article-title":"Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry","volume":"1327","author":"Scheidweiler","year":"2014","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518313426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518313426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T09:07:40Z","timestamp":1540717660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708518313426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":15,"alternative-id":["S0731708518313426"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.09.053","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interactions of pharmacokinetic profiles of Ginkgotoxin and Ginkgolic acids in rat plasma after oral administration","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.09.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}