{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:00:12Z","timestamp":1773018012485,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)"},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160756"],"award-info":[{"award-number":["BK20160756"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jpba.2018.10.036","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T14:38:29Z","timestamp":1540478309000},"page":"241-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC\u2013MS and in silico docking"],"prefix":"10.1016","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-2679","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-hua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2018.10.036_bib0005","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1023\/A:1015539612576","volume":"20","author":"Sheng","year":"2001","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.jpba.2018.10.036_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO;2-Z","volume":"72","author":"Andreasen","year":"1997","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jpba.2018.10.036_bib0015","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1200\/JCO.2006.05.6853","volume":"25","author":"Shariat","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jpba.2018.10.036_bib0020","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0090-4295(02)02522-0","volume":"61","author":"Shariat","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.jpba.2018.10.036_bib0025","first-page":"150","article-title":"APMIS : acta pathologica, microbiologica","volume":"107","author":"Look","year":"1999","journal-title":"Et Immunol. Scand."},{"key":"10.1016\/j.jpba.2018.10.036_bib0030","first-page":"81","volume":"6","author":"Roy","year":"2014","journal-title":"Breast Cancer"},{"key":"10.1016\/j.jpba.2018.10.036_bib0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-94-017-7215-0_10","volume":"867","author":"McMahon","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jpba.2018.10.036_bib0040","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1097\/01.blo0000093845.72468.bd","author":"Choong","year":"2003","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jpba.2018.10.036_bib0045","first-page":"23","article-title":"Nature reviews","volume":"11","author":"Smith","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jpba.2018.10.036_bib0050","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000024518","volume":"18","author":"Evans","year":"1998","journal-title":"Invas. Metastasis"},{"key":"10.1016\/j.jpba.2018.10.036_bib0055","first-page":"274","volume":"51","author":"Ossowski","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.jpba.2018.10.036_bib0060","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0092-8674(83)90093-4","volume":"35","author":"Ossowski","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.jpba.2018.10.036_bib0065","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.2174\/1381612023392676","volume":"8","author":"Rockway","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jpba.2018.10.036_bib0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(87)80039-X","volume":"214","author":"Vassalli","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jpba.2018.10.036_bib0075","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/BF00132208","volume":"13","author":"Wang","year":"1995","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.jpba.2018.10.036_bib0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.biopha.2012.10.003","volume":"67","author":"Tang","year":"2013","journal-title":"Biomed. Pharmacother. Biomed. Pharm."},{"key":"10.1016\/j.jpba.2018.10.036_bib0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/j.1875-9114.1981.tb02539.x","volume":"1","author":"Vidt","year":"1981","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jpba.2018.10.036_bib0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cbpa.2010.02.018","volume":"14","author":"Welsch","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jpba.2018.10.036_bib0095","doi-asserted-by":"crossref","first-page":"13885","DOI":"10.1039\/C4CC04498C","volume":"50","author":"Ma","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jpba.2018.10.036_bib0100","unstructured":"H.L. Ling, in, Jilin University, 2010."},{"key":"10.1016\/j.jpba.2018.10.036_bib0105","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1142\/S0192415X17500136","volume":"45","author":"Zhao","year":"2017","journal-title":"Am. J. Chin. Med."},{"issue":"Suppl 1","key":"10.1016\/j.jpba.2018.10.036_bib0110","first-page":"18","volume":"39","author":"Hostettmann","year":"2001","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jpba.2018.10.036_bib0115","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1021\/ac970132j","volume":"69","author":"van Breemen","year":"1997","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2018.10.036_bib0120","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1039\/C4CC08728C","volume":"51","author":"Song","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jpba.2018.10.036_bib0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.chroma.2016.01.062","volume":"1436","author":"Wu","year":"2016","journal-title":"J. Chromatography. A"},{"key":"10.1016\/j.jpba.2018.10.036_bib0130","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1002\/jssc.201500064","volume":"38","author":"Li","year":"2015","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2018.10.036_bib0135","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fphar.2017.00228","volume":"8","author":"Chen","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2018.10.036_bib0140","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jpba.2017.03.036","volume":"141","author":"Zhao","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.10.036_bib0145","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1002\/cmdc.201600489","volume":"11","author":"Song","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jpba.2018.10.036_bib0150","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.bmc.2011.12.040","volume":"20","author":"Venkatraj","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jpba.2018.10.036_bib0155","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1021\/ml500204e","volume":"5","author":"Papaneophytou","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.jpba.2018.10.036_bib0160","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jpba.2016.11.028","volume":"134","author":"Zhu","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.10.036_bib0165","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1016\/j.bmcl.2014.08.054","volume":"24","author":"Drung","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jpba.2018.10.036_bib0170","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1055\/s-0042-108340","volume":"82","author":"Gertsch","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.jpba.2018.10.036_bib0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/156800909787314002","volume":"9","author":"Ulisse","year":"2009","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.jpba.2018.10.036_bib0180","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s12272-011-0917-2","volume":"34","author":"Park","year":"2011","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.jpba.2018.10.036_bib0185","author":"Seo","year":"2017","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.jpba.2018.10.036_bib0190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.foodchem.2008.07.062","volume":"113","author":"Tian","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.10.036_bib0195","doi-asserted-by":"crossref","first-page":"13917","DOI":"10.3390\/molecules171213917","volume":"17","author":"Zhang","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2018.10.036_bib0200","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3892\/mmr.2012.949","volume":"6","author":"Choi","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jpba.2018.10.036_bib0205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.imr.2016.10.001","volume":"5","author":"Yim","year":"2016","journal-title":"Integr. Medicine Res."},{"issue":"2015","key":"10.1016\/j.jpba.2018.10.036_bib0210","author":"Deiab","year":"2015","journal-title":"Evid-Based Complement. Alternat. Med. : eCAM"},{"key":"10.1016\/j.jpba.2018.10.036_bib0215","first-page":"503","volume":"8","author":"Ata","year":"1996","journal-title":"Oncol. Res."},{"key":"10.1016\/j.jpba.2018.10.036_bib0220","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0031-9422(01)00083-8","volume":"57","author":"Mimaki","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jpba.2018.10.036_bib0225","doi-asserted-by":"crossref","first-page":"10324","DOI":"10.1038\/s41598-017-08602-w","volume":"7","author":"Imaduwage","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2018.10.036_bib0230","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1021\/jf803725h","volume":"57","author":"Kuo","year":"2009","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.jpba.2018.10.036_bib0235","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cplett.2012.02.018","volume":"531","author":"Jacques","year":"2012","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.jpba.2018.10.036_bib0240","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0022-2836(03)00267-5","volume":"328","author":"Zeslawska","year":"2003","journal-title":"J. Mol. Biol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518310677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518310677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T12:40:18Z","timestamp":1565268018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708518310677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":48,"alternative-id":["S0731708518310677"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.10.036","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC\u2013MS and in silico docking","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.10.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}