{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:28:21Z","timestamp":1780957701147,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Zhejiang Provincial Science and Technology Foundation","award":["2017F30005"],"award-info":[{"award-number":["2017F30005"]}]},{"DOI":"10.13039\/100012760","name":"Public Welfare Foundation","doi-asserted-by":"crossref","award":["2016C37074"],"award-info":[{"award-number":["2016C37074"]}],"id":[{"id":"10.13039\/100012760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jpba.2018.10.051","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T01:06:09Z","timestamp":1540947969000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Pharmacokinetic study of sirolimus ophthalmic formulations by consecutive sampling and liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1016","volume":"164","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2018.10.051_bib0005","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/TP.0000000000001107","article-title":"E-selectin mediates immune cell trafficking in corneal transplantation","volume":"100","author":"Dohlman","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.jpba.2018.10.051_bib0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.trre.2007.12.005","article-title":"Immune modulation in corneal transplantation","volume":"22","author":"Fu","year":"2008","journal-title":"Transplant. Rev."},{"key":"10.1016\/j.jpba.2018.10.051_bib0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10792-015-0137-8","article-title":"Systemic cyclosporine and corneal transplantation","volume":"36","author":"Ziaei","year":"2016","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.jpba.2018.10.051_bib0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ajo.2011.01.019","article-title":"Prospective, randomized study of the efficacy of systemic cyclosporine in high-risk corneal transplantation","volume":"152","author":"Shimazaki","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.jpba.2018.10.051_bib0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: one drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jpba.2018.10.051_bib0030","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1126\/science.352.6290.1185-q","article-title":"Why rapamycin is a good immunosuppressant","volume":"352","author":"Foley","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jpba.2018.10.051_bib0035","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1089\/jop.2006.130","article-title":"Formulation of sirolimus eye drops and corneal permeation studies","volume":"23","author":"Buech","year":"2007","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2018.10.051_bib0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12348-010-0015-5","article-title":"A retrospective review of oral low-dose sirolimus (rapamycin) for the treatment of active uveitis","volume":"1","author":"Phillips","year":"2011","journal-title":"J. Ophthalmic Inflamm. Infect."},{"key":"10.1016\/j.jpba.2018.10.051_bib0045","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s11095-013-1192-3","article-title":"A novel rapamycin-polymer conjugate based on a new poly(ethylene glycol) multiblock copolymer","volume":"31","author":"Tai","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jpba.2018.10.051_bib0050","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jconrel.2005.10.008","article-title":"In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelle","volume":"110","author":"Forrest","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpba.2018.10.051_bib0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jchromb.2016.08.022","article-title":"Development of a UPLC\u2013MS\/MS method for the determination of lomefloxacin in rabbit aqueous humor and its application to a pharmacokinetic study","volume":"1033\u20131034","author":"Song","year":"2016","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2018.10.051_bib0060","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jchromb.2017.04.040","article-title":"Simultaneous determination of seven alkaloids from Rhizoma Corydalis Decumbentis in rabbit aqueous humor by LC\u2013MS\/MS: application to ocular pharmacokinetic studies","volume":"1057","author":"Mao","year":"2017","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2018.10.051_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10717544.2014.991952","article-title":"Preparation and ocular pharmacokinetics of hyaluronan acid-modified mucoadhesive liposomes","volume":"23","author":"Lin","year":"2014","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jpba.2018.10.051_bib0070","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejpb.2010.02.006","article-title":"Thiolated quaternary ammonium-chitosan conjugates for enhanced precorneal retention, transcorneal permeation and intraocular absorption of dexamethasone","volume":"75","author":"Zambito","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jpba.2018.10.051_bib0075","first-page":"2769","article-title":"Development and validation of UPLC\/ESI-Q-TOF-MS for carteolol in aqueous humour: stability, stress degradation and application in pharmacokinetic of nanoformulation","volume":"10","author":"Ameeduzzafar","year":"2013","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.jpba.2018.10.051_bib0080","first-page":"95","article-title":"Successful and cost-efficient replacement of immunoassays by tandem mass spectrometry for the quantification of immunosuppressants in the clinical laboratory","volume":"883\u2013884","author":"H\u00e9tu","year":"2011","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2018.10.051_bib0085","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchromb.2013.01.017","article-title":"Simultaneous online SPE-HPLC\u2013MS\/MS analysis of docetaxel, temsirolimus and sirolimus in whole blood and human plasma","volume":"921\u2013922","author":"Navarrete","year":"2013","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2018.10.051_bib0090","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nprot.2009.25","article-title":"A rapid HPLC\u2013MS\/MS method for the simultaneous quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human blood samples","volume":"4","author":"Seger","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jpba.2018.10.051_bib0095","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jchromb.2012.09.014","article-title":"Bioanalytical method validation of rapamycin in ocular matrix by QTRAP LC\u2013MS\/MS: application to rabbit anterior tissue distribution by topical administration of rapamycin nanomicellar formulation","volume":"908","author":"Earla","year":"2012","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2018.10.051_bib0100","series-title":"Guidance for Industry, Bioanalytical Method Validation","author":"U.S. Department of Health and Human Services","year":"2001"},{"key":"10.1016\/j.jpba.2018.10.051_bib0105","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijpharm.2011.03.050","article-title":"Nanosuspensions of poorly soluble drugs: preparation and development by wet milling","volume":"411","author":"Liu","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2018.10.051_bib0110","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1208\/s12249-014-0244-2","article-title":"Nanomicellar topical aqueous drop formulation of rapamycin for back-of-the-eye delivery","volume":"16","author":"Cholkar","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpba.2018.10.051_bib0115","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/jps.22764","article-title":"Ocular pharmacokinetics of a novel tetrahydroquinoline analog in rabbit: compartmental analysis and PK-PD evaluation","volume":"101","author":"Pamulapati","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2018.10.051_bib0120","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1007\/s11095-016-1993-2","article-title":"General pharmacokinetic model for topically administered ocular drug dosage forms","volume":"33","author":"Deng","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jpba.2018.10.051_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-5956-9-8","article-title":"Analysis of protein composition of rabbit aqueous humor following two different cataract surgery incision procedures using 2-DE and LC-MS\/MS","volume":"9","author":"Stastna","year":"2011","journal-title":"Proteome Sci."},{"key":"10.1016\/j.jpba.2018.10.051_bib0130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpba.2018.06.049","article-title":"Analysis of pharmaceuticals and small molecules in aqueous humor","volume":"159","author":"Pietrowska","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.10.051_bib0135","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jpba.2017.10.039","article-title":"Development and validation of an analytical method using UPLC-MS\/MS to quantify everolimus in dried blood spots in the oncology setting","volume":"149","author":"Knapen","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.10.051_bib0140","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1755-3768.2011.02299.x","article-title":"Topical drug delivery to the eye: dorzolamide","volume":"90","author":"Loftsson","year":"2012","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.jpba.2018.10.051_bib0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0975-7406.149810","article-title":"An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention","volume":"7","author":"Gupta","year":"2015","journal-title":"J. Pharm. Bioallied Sci."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518307155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518307155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T15:27:20Z","timestamp":1548257240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708518307155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":29,"alternative-id":["S0731708518307155"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.10.051","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic study of sirolimus ophthalmic formulations by consecutive sampling and liquid chromatography\u2013tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.10.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}