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Chem."},{"key":"10.1016\/j.jpba.2018.11.010_bib0590","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.talanta.2008.04.060","article-title":"Analysis of nitrosamines in water by automated SPE and isotope dilution GC\/HRMS occurrence in the different steps of a drinking water treatment plant, and in chlorinated samples from a reservoir and a sewage treatment plant effluent","volume":"76","author":"Planas","year":"2008","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2018.11.010_bib0595","first-page":"321","article-title":"Determination of eight volatile nitrosamines in thirty cured meat products with capillary gas chromatography-high-resolution mass spectrometry: the presence of nitrosodiethylamine and the absence of nitrosopyrrolidine","author":"Groenen","year":"1976","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.jpba.2018.11.010_bib0600","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1039\/C6AY01169A","article-title":"Application of QuEChERS-based purification coupled with isotope dilution gas chromatography-mass spectrometry method for the determination of N-nitrosamines in soy sauce","volume":"8","author":"Zeng","year":"2016","journal-title":"Anal Methods-Uk"},{"key":"10.1016\/j.jpba.2018.11.010_bib0605","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.foodchem.2005.04.009","article-title":"Volatile N-nitrosamines in various fish products","volume":"96","author":"Yurchenko","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.11.010_bib0610","first-page":"77","article-title":"Analysis of nitrosamines in foods and beverages","volume":"77","author":"Yeh","year":"1998","journal-title":"Chromatogr. Sci. 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Soc."},{"key":"10.1016\/j.jpba.2018.11.010_bib0670","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1039\/C8AY00014J","article-title":"Online coupling of tandem liquid- phase extraction with HPLC-UV for the determination of trace N-nitrosamines in food products","volume":"10","author":"Li","year":"2018","journal-title":"Anal. Methods-Uk"},{"key":"10.1016\/j.jpba.2018.11.010_bib0675","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4236\/pp.2014.53037","article-title":"Validated RP-HPLC method for the determination of seven volatile N-nitrosamines in meat","volume":"05","author":"Al-Kaseem","year":"2014","journal-title":"Pharmacol. 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A."},{"key":"10.1016\/j.jpba.2018.11.010_bib0840","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.chemosphere.2016.06.094","article-title":"A rapid and reliable technique for N-nitrosodimethylamine analysis in reclaimed water by HPLC-photochemical reaction-chemiluminescence","volume":"161","author":"Fujioka","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.jpba.2018.11.010_bib0845","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jfda.2015.10.006","article-title":"Analysis of N-nitrosodiethylamine by ion chromatography coupled with UV photolysis pretreatment","volume":"24","author":"Li","year":"2016","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jpba.2018.11.010_bib0850","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.aca.2006.02.059","article-title":"High-performance liquid chromatography with fluorescence detection for aqueous analysis of nanogram-level N-nitrosodimethylamine","volume":"566","author":"Cha","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2018.11.010_bib0855","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9673(01)01547-3","article-title":"Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection","volume":"946","author":"Cardenes","year":"2002","journal-title":"J. Chromatogr. 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Chem."},{"key":"10.1016\/j.jpba.2018.11.010_bib0985","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/jat\/bkw038","article-title":"Long-term stability of volatile nitrosamines in human urine","volume":"40","author":"Hodgson","year":"2016","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jpba.2018.11.010_bib0990","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jpba.2015.08.021","article-title":"A chemometric optimization of method for determination of nitrosamines in gastric juices by GC-MS","volume":"117","author":"Akyuz","year":"2016","journal-title":"J. Pharm. Biomed. 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Methods"},{"key":"10.1016\/j.jpba.2018.11.010_bib1020","first-page":"618","article-title":"Determination of four volatile n-nitrosamines in the process of Chinese preserved meat","author":"Zhu","year":"2015","journal-title":"International Conference on Materials, Environmental and Biological Engineering"},{"key":"10.1016\/j.jpba.2018.11.010_bib1025","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.foodchem.2010.11.149","article-title":"Influence of putrescine, cadaverine, spermidine or spermine on the formation of N-nitrosamine in heated cured pork meat","volume":"126","author":"Drabik-Markiewicz","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2018.11.010_bib1030","doi-asserted-by":"crossref","first-page":"C560","DOI":"10.1111\/j.1750-3841.2012.02667.x","article-title":"Influence of various cooking methods on the concentrations of volatile N\u2010nitrosamines and biogenic amines in dry\u2010cured sausages","volume":"77","author":"Li","year":"2012","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jpba.2018.11.010_bib1035","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1023\/A:1016652213062","article-title":"Determination of volatile N-nitrosamines in food by high-performance liquid chromatography with fluorescence detection","volume":"56","author":"Komarova","year":"2001","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.jpba.2018.11.010_bib1040","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.meatsci.2008.09.005","article-title":"Irradiated Chinese Rugao ham: changes in volatile N-nitrosamine, biogenic amine and residual nitrite during ripening and post-ripening","volume":"81","author":"Wei","year":"2009","journal-title":"Meat Sci."},{"key":"10.1016\/j.jpba.2018.11.010_bib1045","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/jf60226a052","article-title":"Volatile nitrosamines in various cured meat-products - effect of cooking and recent trends","volume":"27","author":"Sen","year":"1979","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpba.2018.11.010_bib1050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jsfa.2740270217","article-title":"Distribution of some volatile nitrosamines in cooked bacon","volume":"27","author":"Gough","year":"1976","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.jpba.2018.11.010_bib1055","article-title":"Use of vacuum distillation and gas chromatography-mass spectrometry for determination of low levels of volatile nitrosamines in meat products","volume":"19","author":"Telling","year":"1971","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpba.2018.11.010_bib1060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0015-6264(78)80190-4","article-title":"A sensitive method for the colorimetric determination of volatile nitrosamines in food products and air","volume":"16","author":"C\u0306eh","year":"1978","journal-title":"Food Cosmet. Toxicol."},{"key":"10.1016\/j.jpba.2018.11.010_bib1065","unstructured":"ASTM, Standard Specification for Volatile N-Nitrosamine Levels in Rubber Nipples on Pacifiers, in: ASTM International, ASTM F1313-90(2011), 2011."},{"key":"10.1016\/j.jpba.2018.11.010_bib1070","series-title":"EN 12868","article-title":"Child use and care articles. 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