{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:59:35Z","timestamp":1772776775155,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Important Drug Development Fund, Ministry of Science and Technology of China","award":["2015ZX09501004-003-004"],"award-info":[{"award-number":["2015ZX09501004-003-004"]}]},{"DOI":"10.13039\/501100001809","name":"Program for National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81703934"],"award-info":[{"award-number":["81703934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jpba.2018.11.034","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T12:00:37Z","timestamp":1542369637000},"page":"672-680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Pharmacokinetic studies unveiled the drug\u2013drug interaction between trans-2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix"],"prefix":"10.1016","volume":"164","author":[{"given":"Yanchao","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youcai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2018.11.034_bib0005","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.carbpol.2013.09.007","article-title":"Purification, antioxidant activity and antiglycation of polysaccharides from Polygonum multiflorum Thunb","volume":"99","author":"Lv","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpba.2018.11.034_bib0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejphar.2012.05.045","article-title":"Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells","volume":"689","author":"Zhang","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpba.2018.11.034_bib0015","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jpba.2009.02.014","article-title":"Simultaneous determination of five anthraquinones in medicinal plants and pharmaceutical preparations by HPLC with fluorescence detection","volume":"49","author":"He","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.11.034_bib0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5009\/gnl.2009.3.1.52","article-title":"Reactivation of pulmonary tuberculosis in a patient with Polygonum multiflorum Thunb-induced hepatitis","volume":"3","author":"Cho","year":"2009","journal-title":"Gut Liver"},{"key":"10.1016\/j.jpba.2018.11.034_bib0025","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2169\/internalmedicine.49.3509","article-title":"Toxic hepatitis induced by show-wu-pian, a Chinese herbal preparation","volume":"49","author":"Furukawa","year":"2010","journal-title":"Intern. Med."},{"key":"10.1016\/j.jpba.2018.11.034_bib0030","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ctim.2013.12.008","article-title":"Eighteen cases of liver injury following ingestion of Polygonum multiflorum","volume":"22","author":"Dong","year":"2014","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.jpba.2018.11.034_bib0035","unstructured":"China Food and Drug Administration [EB\/OL]. 2014: http:\/\/www.sfda.gov.cn\/WS01\/CL0847\/102806.htmlhttp:\/\/www.sfda.gov.cn\/WS01\/CL0078\/102903.html."},{"key":"10.1016\/j.jpba.2018.11.034_bib0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpba.2012.07.031","article-title":"Determination of emodin in L-02 cells and cell culture media with liquid chromatography-mass spectrometry: application to a cellular toxicokinetic study","volume":"71","author":"Li","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.11.034_bib0045","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/bmc.3456","article-title":"Characterization of the constituents in rat plasma after oral administration of radix polygoni multiflori extracts by ultraperformance liquid chromatography\/quadrupole time-of-flight mass spectrometry","volume":"29","author":"Lin","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2018.11.034_bib0050","doi-asserted-by":"crossref","first-page":"17952","DOI":"10.1038\/s41598-017-18231-y","article-title":"Identification and characterization of the structure\u2013activity relationships involved in UGT1A1inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2018.11.034_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2017.00349","article-title":"A new perspective on liver injury by traditional Chinese herbs such as polygonum multiflorum: the geographical area of harvest as an important contributory factor","volume":"8","author":"Lin","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2018.11.034_bib0060","first-page":"1","article-title":"Interpretation the hepatotoxicity based on pharmacokinetics investigated through oral administrated different extraction parts of polygonum multiflorum on rats","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2018.11.034_bib0065","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tiv.2017.01.022","article-title":"Polygoni multiflora radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes","volume":"40","author":"Kang","year":"2017","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.jpba.2018.11.034_bib0070","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1039\/C4TX00246F","article-title":"Metabolomic profiling of emodin-induced cytotoxicity inhuman liver cells and mechanistic study","volume":"4","author":"Liu","year":"2015","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jpba.2018.11.034_bib0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11684-017-0508-9","article-title":"Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum","volume":"2","author":"Li","year":"2017","journal-title":"Front. Med."},{"key":"10.1016\/j.jpba.2018.11.034_bib0080","first-page":"333","article-title":"Investigation of potential toxic factors for fleece-flower root: from perspective of processing methods evolution","volume":"41","author":"Cui","year":"2016","journal-title":"Chin. J. Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2018.11.034_bib0085","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2018.11.034_bib0090","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/10408440701215233","article-title":"Toxicological significance of mechanism-based inactivation of cytochromep450 enzymes by drugs","volume":"37","author":"Masubuchi","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.jpba.2018.11.034_bib0095","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1124\/dmd.107.014738","article-title":"Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-\/-) mice","volume":"35","author":"Wolf","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2018.11.034_bib0100","first-page":"47","article-title":"Effects of Polygonum multiflorum on the activity of cytochrome P450 isoforms in rats","volume":"70","author":"Zhang","year":"2015","journal-title":"Pharmazie"},{"key":"10.1016\/j.jpba.2018.11.034_bib0105","series-title":"Guidance for Industry: Drug Interaction Studies-study Design, Data Analysis, Implications for Dosing and Labeling Recommendations (Draft)","author":"Food and Drug Administration","year":"2012"},{"key":"10.1016\/j.jpba.2018.11.034_bib0110","series-title":"Guideline on the Investigation of Drug Interactions","author":"European Medicines Agency","year":"2012"},{"key":"10.1016\/j.jpba.2018.11.034_bib0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpba.2017.03.016","article-title":"Rapid profiling and pharmacokinetic studies of major compounds in crude extract from Polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC\u2013MS\/MS","volume":"140","author":"Wang","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2018.11.034_bib0120","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fphar.2018.00505","article-title":"Interpretation the hepatotoxicity based on pharmacokinetics investigated through oral administrated different extraction parts of Polygonum multiflorum on rats","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2018.11.034_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11684-017-0508-9","article-title":"Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum","volume":"11","author":"Li","year":"2017","journal-title":"Front. Med."},{"key":"10.1016\/j.jpba.2018.11.034_bib0130","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tiv.2017.01.022","article-title":"Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes","volume":"40","author":"Kang","year":"2017","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.jpba.2018.11.034_bib0135","first-page":"14","article-title":"In vitro metabolism of emodin in human liver microsomes","volume":"21","author":"Ouyang","year":"2015","journal-title":"Guid. J. Tradit. Chin. Med. Pharm."},{"key":"10.1016\/j.jpba.2018.11.034_bib0140","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.4238\/2014.July.25.19","article-title":"CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum","volume":"13","author":"Ma","year":"2014","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.jpba.2018.11.034_bib0145","article-title":"Hepatotoxicity in rats induced by aqueous extract of Polygoni Multiflori Radix, root of Polygonum multiflorum related to the activity inhibition of CYP1A2 or CYP2E1","volume":"2017","author":"Li","year":"2017","journal-title":"Evid.-based Complement. Altern. Med."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518321770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708518321770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T15:35:54Z","timestamp":1548257754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708518321770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":29,"alternative-id":["S0731708518321770"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2018.11.034","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic studies unveiled the drug\u2013drug interaction between trans-2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2018.11.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}