{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:30:34Z","timestamp":1760056234496,"version":"build-2065373602"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.jpba.2019.04.038","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T11:45:20Z","timestamp":1555587920000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A simple and sensitive LC-MS\/MS method for quantification of Bepridil in rat plasma and its application to pharmacokinetic studies"],"prefix":"10.1016","volume":"172","author":[{"given":"Bhavesh D.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nageswararao","family":"Palakundam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Alamanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit R.","family":"Gadekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amol A.","family":"Raje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakshit","family":"Ameta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2019.04.038_bib0005","first-page":"487","article-title":"Bepridil: a new long-acting calcium channel blocking agent","volume":"21","author":"Zeller","year":"1987","journal-title":"Drug Intell. Clin. Pharm."},{"key":"10.1016\/j.jpba.2019.04.038_bib0010","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2165\/00003495-199244050-00009","article-title":"A review of its pharmacological properties and therapeutic use in stable angina pectoris","volume":"44","author":"Hollingshead","year":"1992","journal-title":"Drugs."},{"key":"10.1016\/j.jpba.2019.04.038_bib0015","series-title":"Curr. Cardiovasc. DRUGS","first-page":"148","article-title":"Calcum antagonists","author":"William","year":"2005"},{"key":"10.1016\/j.jpba.2019.04.038_bib0020","first-page":"97","article-title":"Nicardipine, nitrendipine, and bepridil: new calcium antagonists for cardiovascular disorders","volume":"7","author":"Hasegawa","year":"1988","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.jpba.2019.04.038_bib0025","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1136\/heart.89.12.1415","article-title":"A case of bepridil induced interstitial pneumonit","volume":"89","author":"Gaku","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.jpba.2019.04.038_bib0030","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2169\/internalmedicine.48.2490","article-title":"Gradual progression of interstitial pneumonia induced by bepridil","volume":"48","author":"Suzuki","year":"2009","journal-title":"Intern. Med."},{"key":"10.1016\/j.jpba.2019.04.038_bib0035","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1253\/circj.CJ-08-0234","article-title":"Two patients with bepridil-induced interstitial pneumonia","volume":"73","author":"Masataka Watanabe","year":"2009","journal-title":"Circ. J."},{"key":"10.1016\/j.jpba.2019.04.038_bib0040","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.rmed.2013.09.023","article-title":"Incidence and outcomes of bepridil-induced interstitial pneumonia","volume":"107","author":"Yamasaki","year":"2013","journal-title":"Respir. Med."},{"key":"10.1016\/j.jpba.2019.04.038_bib0045","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5597","article-title":"A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity","volume":"7","author":"Johansen","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jpba.2019.04.038_bib0050","doi-asserted-by":"crossref","first-page":"S672","DOI":"10.1093\/infdis\/jiy304","article-title":"Identification of combinations of approved drugs with synergistic activity against ebola virus in cell cultures","author":"Dyall","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jpba.2019.04.038_bib0055","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/infdis\/jiy332","article-title":"The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease","volume":"218","author":"Dewald","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jpba.2019.04.038_bib0060","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/acs.jmedchem.7b01249","article-title":"Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection","volume":"61","author":"Ren","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jpba.2019.04.038_bib0065","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ijc.31355","article-title":"Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia","volume":"143","author":"Baldoni","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jpba.2019.04.038_bib0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-4347(00)86105-8","article-title":"Determinatin of the anti-ischaemic drug Bepridil in human plasma using gas chropamatography with nitrogen sensitive detection","volume":"272","author":"Jan Vink","year":"1983","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2019.04.038_bib0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-4347(84)80012-2","article-title":"Determination of Bepridil in biological fluids by high\u2010performance liquid chromatography","volume":"309","author":"Kung-Tat","year":"1984","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2019.04.038_bib0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-4347(00)83255-7","article-title":"Automated capillary gas chromatographic assay using nitrogen-phosphorus ionization detectionn for the determinatin of Bepridil in human plasma","volume":"374","author":"Holland","year":"1986","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpba.2019.04.038_bib0085","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/chrsci\/49.7.519","article-title":"An LC method for quantifying bepridil in human plasma using 1-naphthol as the internal standard","volume":"49","author":"Noda","year":"2011","journal-title":"J. Chromatogr. Sci."},{"year":"2018","series-title":"Center for Drug Evaluation and Research (CDER) and Center for Veterinary Medicine (CVM)","author":"U.S. Department of Health and Human Services Food and Drug Administration","key":"10.1016\/j.jpba.2019.04.038_bib0090"},{"year":"2012","series-title":"Guideline on Bioanalytical Method Validation","author":"European Medicines Agency","key":"10.1016\/j.jpba.2019.04.038_bib0095"},{"key":"10.1016\/j.jpba.2019.04.038_bib0100","doi-asserted-by":"crossref","first-page":"E30","DOI":"10.1208\/aapsj0901004","article-title":"Workshop\/Conference report--quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays","volume":"1","author":"Viswanathan","year":"2007","journal-title":"AAPS J."},{"key":"10.1016\/j.jpba.2019.04.038_bib0105","first-page":"112","article-title":"Simple and reliable method for serial sampling of blood from rats","volume":"833","author":"Upton","year":"1973","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2019.04.038_bib0110","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1080\/00498254.2017.1404168","article-title":"Evaluation of separate role of intestine and liver in first pass metabolism of budesonide in rat","volume":"48","author":"Raje","year":"2017","journal-title":"Xenobiotica"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519305928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519305928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:55:31Z","timestamp":1760000131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708519305928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":22,"alternative-id":["S0731708519305928"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.04.038","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A simple and sensitive LC-MS\/MS method for quantification of Bepridil in rat plasma and its application to pharmacokinetic studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.04.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}