{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:05:16Z","timestamp":1785186316342,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803382"],"award-info":[{"award-number":["81803382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"scientific research funds of talents from Xuzhou Medical University","award":["D2017016"],"award-info":[{"award-number":["D2017016"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170253"],"award-info":[{"award-number":["BK20170253"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20181147"],"award-info":[{"award-number":["BK20181147"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Xuzhou City","award":["KC18045"],"award-info":[{"award-number":["KC18045"]}]},{"name":"Jiangsu University Natural Science Foundation of China","award":["16KJA350001"],"award-info":[{"award-number":["16KJA350001"]}]},{"name":"Jiangsu University Natural Science Foundation of China","award":["17KJB350013"],"award-info":[{"award-number":["17KJB350013"]}]},{"name":"Innovative and Entrepreneurial Talent Scheme of Jiangsu Province","award":["2017"],"award-info":[{"award-number":["2017"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jpba.2019.05.055","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T11:52:04Z","timestamp":1559217124000},"page":"367-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet"],"prefix":"10.1016","volume":"174","author":[{"given":"Shuai","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-yu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-su","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-zhe","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao-quan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2019.05.055_bib0005","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jchromb.2014.06.003","article-title":"An efficient preparative procedure for main flavonoids from the peel of Trichosanthes kirilowiiMaxim. using polyamide resin followed by semi-preparative high performance liquid chromatography","volume":"965","author":"Li","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2019.05.055_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03602532.2015.1124888","article-title":"Pharmacokinetic herb-drug interactions with traditional Chinese medicine: progress, causes of conflicting results and suggestions for future research","volume":"48","author":"Ma","year":"2016","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jpba.2019.05.055_bib0015","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2174\/1389200216666150223152627","article-title":"CYP3A4-mediated pharmacokinetic interactions in cancer therapy","volume":"15","author":"Tian","year":"2014","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jpba.2019.05.055_bib0020","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2174\/1389200216666150223152113","article-title":"Are circulating metabolites important in pharmacokinetic drug-drug interactions? A retro-analysis of clinical data","volume":"15","author":"Zhao","year":"2014","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jpba.2019.05.055_bib0025","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jpba.2015.04.033","article-title":"Urinary metabolomic strategy to evaluate Compound Danshen Dripping Pills for myocardial ischaemia in rats","volume":"112","author":"Zou","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.05.055_bib0030","first-page":"46","article-title":"Systematic review and meta-analysis of randomized controlled trials comparing compound Danshen Dripping Pills and isosorbide dinitrate in treating angina pectoris","volume":"182C","author":"Yao","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jpba.2019.05.055_bib0035","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(96)09457-3","article-title":"A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)","volume":"348","author":"CAPRIE Steering Committee","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2019.05.055_bib0040","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJMoa010746","article-title":"Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation","volume":"345","author":"Yusuf","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jpba.2019.05.055_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/821641","article-title":"Clinical pathways based on integrative medicine in Chinese hospitals improve treatment outcomes for patients with acute myocardial infarction: a multicentre, nonrandomized historically controlled trial","volume":"2012","author":"Wang","year":"2012","journal-title":"Evid.-Based Compl. Alt."},{"key":"10.1016\/j.jpba.2019.05.055_bib0050","doi-asserted-by":"crossref","first-page":"836","DOI":"10.3109\/00498250903191427","article-title":"Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel","volume":"39","author":"Nishiya","year":"2009","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jpba.2019.05.055_bib0055","article-title":"Salvia miltiorrhiza roots against cardiovascular disease: consideration of herb-drug interactions","volume":"2017","author":"Chen","year":"2017","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.jpba.2019.05.055_bib0060","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-2125.2010.03624.x","article-title":"Effect of danshen extract on the activity of CYP3A4 in healthy volunteers","volume":"69","author":"Qiu","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2019.05.055_bib0065","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1255\/ejms.1137","article-title":"Simultaneous determination of six phenolic constituents of danshen injection in rat plasma by liquid chromatography-electrospray ionization-mass spectrometry and its application to a pharmacokinetic study","volume":"17","author":"Zhao","year":"2011","journal-title":"Eur. J. Mass Spectrom. Chichester (Chichester)"},{"key":"10.1016\/j.jpba.2019.05.055_bib0070","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/bmc.968","volume":"22","author":"Park","year":"2008","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2019.05.055_bib0075","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1016\/j.jchromb.2010.10.007","article-title":"Simultaneous determination of three Panax notoginseng saponins at sub-nanograms by LC-MS\/MS in dog plasma for pharmacokinetics of compound Danshen tablets","volume":"878","author":"Song","year":"2010","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2019.05.055_bib0080","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.fct.2018.02.051","article-title":"Effects of Danshen capsules on the pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers","volume":"119","author":"Zhou","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jpba.2019.05.055_bib0085","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1021\/acs.analchem.6b03183","article-title":"Simultaneous analysis of free and sulfated steroids by liquid chromatography\/mass spectrometry with selective mass spectrometric scan modes and polarity switching","volume":"88","author":"Lee","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2019.05.055_bib0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.aca.2018.02.059","article-title":"Supported liquid extraction coupled to gas chromatography-selective mass spectrometric scan modes for serum steroid profiling","volume":"1037","author":"Moon","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2019.05.055_bib0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jpba.2019.05.055_bib0100","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1016\/j.chroma.2010.04.054","article-title":"Influence of segmental and selected ion monitoring on quantitation of multi-component using high-pressure liquid chromatography-quadrupole mass spectrometry: simultaneous detection of 16 saponins in rat plasma as a case","volume":"1217","author":"Liang","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2019.05.055_bib0105","series-title":"Guidance for Industry-Bioanalytical Method Validation","year":"2018"},{"key":"10.1016\/j.jpba.2019.05.055_bib0110","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/00498250701767675","article-title":"Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases","volume":"38","author":"Bi","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jpba.2019.05.055_bib0115","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1124\/dmd.110.033845","article-title":"Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship","volume":"38","author":"Hao","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2019.05.055_bib0120","first-page":"29","article-title":"Pharmacokinetic profile of 14C-labeled clopidogrel","volume":"25","author":"Lins","year":"1999","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.jpba.2019.05.055_bib0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/dmd.109.029132","article-title":"Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite","volume":"38","author":"Kazui","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2019.05.055_bib0130","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/789142","article-title":"Synergistic effects of clopidogrel and Fufang Danshen Dripping Pills by modulation of the metabolism target and pharmacokinetics","volume":"2014","author":"Ma","year":"2014","journal-title":"Evid.-Based Compl. Alt."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851930398X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851930398X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T20:31:29Z","timestamp":1569357089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170851930398X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":26,"alternative-id":["S073170851930398X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.05.055","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.05.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}