{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:18:48Z","timestamp":1790065128026,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673715"],"award-info":[{"award-number":["81673715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473287"],"award-info":[{"award-number":["81473287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jpba.2019.06.043","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T01:38:17Z","timestamp":1561945097000},"page":"683-695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Development of an underivatized LC-MS\/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats"],"prefix":"10.1016","volume":"174","author":[{"given":"Xue-Mei","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jie","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Rang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jia","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2019.06.043_bib0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fpsyt.2015.00117","article-title":"Commentary: Consistent Superiority of Selective Serotonin Reuptake Inhibitors Over Placebo in Reducing Depressed Mood in Patients with Major Depression","volume":"6","author":"Fried","year":"2015","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jpba.2019.06.043_bib0010","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1176\/appi.ps.201300059","article-title":"A review of the clinical, economic, and societal burden of treatment-resistant depression","volume":"65","author":"Mrazek","year":"2014","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.jpba.2019.06.043_bib0015","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1021\/acs.jproteome.6b00577","article-title":"Targeted Metabolomic Pathway Analysis and Validation Revealed Glutamatergic Disorder in the Prefrontal Cortex among the Chronic Social Defeat Stress Mice Model of Depression","volume":"15","author":"Wang","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2019.06.043_bib0020","first-page":"357","article-title":"Kynurenines: tryptophan\u2019s metabolites in exercise, inflammation, and mental health","volume":"28","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jpba.2019.06.043_bib0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jchromb.2015.02.037","article-title":"Determination of depression biomarkers in rat plasma by liquid chromatography-mass spectrometry for the study of the antidepressant effect of Zhi-Zi-Hou-Po decoction on rat model of chronic unpredictable mild stress","volume":"988","author":"Xing","year":"2015","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2019.06.043_bib0030","doi-asserted-by":"crossref","first-page":"906","DOI":"10.4088\/JCP.13r08908","article-title":"Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis","volume":"75","author":"Ogawa","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jpba.2019.06.043_bib0035","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.pharmthera.2012.09.005","article-title":"Integrative physiology of depression and antidepressant drug action: implications for serotonergic mechanisms of action and novel therapeutic strategies for treatment of depression","volume":"137","author":"Hale","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2019.06.043_bib0040","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s11011-018-0290-7","article-title":"IDO and TDO as a potential therapeutic target in different types of depression","volume":"33","author":"Qin","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jpba.2019.06.043_bib0045","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1472-8206.2004.00287.x","article-title":"Dopamine, depression and antidepressants","volume":"18","author":"Dailly","year":"2004","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2019.06.043_bib0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpsychires.2017.09.014","article-title":"Plasma amino acid profile in major depressive disorder: analyses in two independent case-control sample sets","volume":"96","author":"Ogawa","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jpba.2019.06.043_bib0055","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.biopsych.2016.05.005","article-title":"Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine","volume":"81","author":"Lener","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jpba.2019.06.043_bib0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2004.06.072","article-title":"Chronic antidepressant treatment alters serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons","volume":"129","author":"Zhong","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpba.2019.06.043_bib0065","doi-asserted-by":"crossref","first-page":"10044","DOI":"10.1021\/ac3025202","article-title":"Quantitative analysis of neurochemical panel in rat brain and plasma by liquid chromatography-tandem mass spectrometry","volume":"84","author":"Zheng","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2019.06.043_bib0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.aca.2013.08.033","article-title":"Simultaneous determination of amino acids and carbohydrates in culture media of Clostridium thermocellum by valve-switching ion chromatography","volume":"798","author":"Fa","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2019.06.043_bib0075","doi-asserted-by":"crossref","first-page":"8448","DOI":"10.1021\/ac401920v","article-title":"Capillary electrophoresis-mass spectrometry-based detection of drugs and neurotransmitters in Drosophila brain","volume":"85","author":"Phan","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2019.06.043_bib0080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.chroma.2016.01.023","article-title":"Targeting tryptophan and tyrosine metabolism by liquid chromatography tandem mass spectrometry","volume":"14","author":"Marcos","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2019.06.043_bib0085","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jpba.2016.04.002","article-title":"LC\/MS-based metabolomics strategy to assess the amelioration effects of ginseng total saponins on memory deficiency induced by simulated microgravity","volume":"125","author":"Feng","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.06.043_bib0090","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cca.2015.12.023","article-title":"Simultaneous determination of 8 neurotransmitters and their metabolite levels in rat brain using liquid chromatography in tandem with mass spectrometry : application to the murine Nrf2 model of depression","volume":"453","author":"Wojnicz","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jpba.2019.06.043_bib0095","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jchromb.2016.06.011","article-title":"Validated methods for determination of neurotransmitters and metabolites in rodent brain tissue and extracellular fluid by reversed phase UHPLC\u2013MS\/MS","volume":"1028","author":"Bergh","year":"2016","journal-title":"J Chromatogr B."},{"key":"10.1016\/j.jpba.2019.06.043_bib0100","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jchromb.2017.12.015","article-title":"A novel liquid chromatography\/mass spectrometry method for determination ofneurotransmitters in brain tissue: Application to human tauopathies","volume":"1073","author":"Forgacsova","year":"2018","journal-title":"J Chromatogr B."},{"key":"10.1016\/j.jpba.2019.06.043_bib0105","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jpba.2016.06.017","article-title":"Quantitative analysis of endogenous compounds","volume":"128","author":"Thakare","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.06.043_bib0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroscience.2017.12.001","article-title":"Integrated Metabolomics and Proteomics Analysis of Hippocampus in a Rat Model of Depression","volume":"371","author":"Zhang","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpba.2019.06.043_bib0115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ab.2009.09.015","article-title":"Determination of dansylated monoamine and amino acid neurotransmitters and their metabolites in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"396","author":"Cai","year":"2010","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jpba.2019.06.043_bib0120","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.biopsych.2010.09.011","article-title":"Magnetic Resonance Spectroscopy Studies of the Glutamatergic System in Mood Disorders: A Pathway to Diagnosis, Novel Therapeutics, and Persona-lized Medicine?","volume":"68","author":"Salvadore","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jpba.2019.06.043_bib0125","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1600-0447.2011.01706.x","article-title":"Mood effects of the amino acids tryptophan and tyrosine:\u2019 Food for Thought\u2019 III","volume":"124","author":"Parker","year":"2011","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jpba.2019.06.043_bib0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbi.2015.11.003","article-title":"Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder","volume":"53","author":"Meier","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jpba.2019.06.043_bib0135","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2018.00552","article-title":"The metabolic factor kynurenic acid of kynurenine pathway predicts major depressive disorder","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Psychiatry"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519308982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519308982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T20:31:30Z","timestamp":1569357090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708519308982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":27,"alternative-id":["S0731708519308982"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.06.043","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of an underivatized LC-MS\/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.06.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}