{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:17:39Z","timestamp":1760300259218,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jpba.2019.07.024","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T22:05:03Z","timestamp":1563487503000},"page":"112776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Simulation of phase I metabolism reactions of selected calcium channel blockers by human liver microsomes and photochemical methods with the use of Q-TOF LC\/MS"],"prefix":"10.1016","volume":"175","author":[{"given":"Maciej","family":"Gawlik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Trawi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Skibi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2019.07.024_bib0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/med.1016","article-title":"Role of drug metabolism in drug discovery and development","volume":"21","author":"Kumar","year":"2001","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jpba.2019.07.024_bib0010","doi-asserted-by":"crossref","DOI":"10.1002\/9780470921920.edm001","article-title":"Review of drug metabolism in drug discovery and development","author":"White","year":"2012","journal-title":"Encycl. Drug Metab. Interact."},{"key":"10.1016\/j.jpba.2019.07.024_bib0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd4581","article-title":"Predicting drug metabolism: experiment and\/or computation?","volume":"14","author":"Kirchmair","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jpba.2019.07.024_bib0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/03602530701497804","article-title":"LC-MS-based metabolomics in drug metabolism","volume":"39","author":"Chen","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jpba.2019.07.024_bib0025","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jpba.2007.02.006","article-title":"Recent advances in high-throughput quantitative bioanalysis by LC\u2013MS\/MS","volume":"44","author":"Naxing Xu","year":"2007","journal-title":"J. Pharm. Biomed."},{"key":"10.1016\/j.jpba.2019.07.024_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1081\/DMR-200046955","article-title":"Human metabolism and metabolic interactions of deployment-related chemicals","volume":"37","author":"Hodgson","year":"2005","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jpba.2019.07.024_bib0035","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/10837450902891295","article-title":"Drug metabolism and pharmacokinetics","volume":"41","author":"Benedetti","year":"2009","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jpba.2019.07.024_bib0040","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s12010-009-8689-6","article-title":"Role of human liver microsomes in in vitro metabolism of drugs-a review","volume":"160","author":"Asha","year":"2010","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jpba.2019.07.024_bib0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/238037a0","article-title":"Electrochemical photolysis of water at a semiconductor electrode","volume":"238","author":"Fujishima","year":"1972","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2019.07.024_bib0050","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ejps.2018.01.013","article-title":"Imitation of phase I metabolism reactions of MAO-A inhibitors by titanium dioxide photocatalysis","volume":"1","author":"Gawlik","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2019.07.024_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jphotobiol.2012.10.013","article-title":"Synthesis of metabolites of paracetamol and cocaine via photooxidation on TiO2 catalyzed by UV light","volume":"5","author":"Raoof","year":"2013","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.jpba.2019.07.024_bib0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejps.2015.12.012","article-title":"Comparison of TiO2 photocatalysis, electrochemically assisted Fenton reaction and direct electrochemistry for simulation of phase I metabolism reactions of drugs","volume":"83","author":"Ruokolainen","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2019.07.024_bib0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejps.2014.08.009","article-title":"Imitation of phase I oxidative metabolism of anabolic steroids by titanium dioxide photocatalysis","volume":"65","author":"Ruokolainen","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2019.07.024_bib0070","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/dta.334","article-title":"Horse metabolism and the photocatalytic process as a tool to identify metabolic products formed from dopant substances: the case of sildenafil","volume":"3","author":"Medana","year":"2011","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2019.07.024_bib0075","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4297","article-title":"Simulation of phase I metabolism reactions of clozapine by HLM and photocatalytic methods with the use of UHPLC-ESI-MS\/MS","author":"Gawlik","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2019.07.024_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijms.2018.08.008","article-title":"Identification of new metabolites of vardenafil with the use of HLM and photochemical methods by LC-ESI-HRMS combined with multivariate chemometric analysis","author":"Gawlik","year":"2018","journal-title":"Int. J. Mass Spectrom."},{"key":"10.1016\/j.jpba.2019.07.024_bib0085","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1524-6175.2005.04140.x","article-title":"Pharmacotherapy review: calcium channel blockers","volume":"8","author":"Sica","year":"2006","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.jpba.2019.07.024_bib0090","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0167-5273(83)90030-X","article-title":"Antianginal efficacy of perhexiline maleate in patients refractory to beta- adrenoreceptor blockade","volume":"3","author":"Harvey","year":"1983","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jpba.2019.07.024_bib0095","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0378-4347(00)83354-X","article-title":"Single-dose pharmacokinetics of perhexiline administered orally to humans","volume":"305","author":"Amoah","year":"1984","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2019.07.024_bib0100","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/01.CIR.81.4.1260","article-title":"Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent","volume":"81","author":"Cole","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jpba.2019.07.024_bib0105","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.4155\/bio-2017-0068","article-title":"The validation of an LC-MS\/MS assay for perhexiline and major hydroxy metabolites, and its application to therapeutic monitoring in patient plasma","volume":"9","author":"Camilleri","year":"2017","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpba.2019.07.024_bib0110","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1161\/CIRCULATIONAHA.105.551457","article-title":"Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment","volume":"112","author":"Lee","year":"2005","journal-title":"Circulation"},{"year":"2009","series-title":"Meyler\u2019s Side Effects of Cardiovascular Drugs","author":"Aronson","key":"10.1016\/j.jpba.2019.07.024_bib0115"},{"key":"10.1016\/j.jpba.2019.07.024_bib0120","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2125.2003.01805.x","article-title":"Polymorphic hydroxylation of perhexiline in vitro","volume":"55","author":"S\u00f8rensen","year":"2003","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2019.07.024_bib0125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1124\/dmd.106.012252","article-title":"CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes","volume":"35","author":"Davies","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpba.2019.07.024_bib0130","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF02455990","article-title":"Studies on the metabolism of perhexiline in man","volume":"32","author":"Cooper","year":"1987","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2019.07.024_bib0135","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02089960","article-title":"Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy","volume":"14","author":"Singlas","year":"1978","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2019.07.024_bib0140","doi-asserted-by":"crossref","first-page":"B11","DOI":"10.1016\/0002-9149(87)90077-4","article-title":"Classification of calcium antagonists","volume":"59","author":"Godfraind","year":"1987","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jpba.2019.07.024_bib0145","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2165\/00003495-198938040-00002","article-title":"Flunarizine","volume":"38","author":"Todd","year":"1989","journal-title":"Drugs"},{"key":"10.1016\/j.jpba.2019.07.024_bib0150","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3109\/00498259209053143","article-title":"Comparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes","volume":"22","author":"Lavrijsen","year":"1992","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jpba.2019.07.024_bib0155","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1248\/bpb.19.1511","article-title":"Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes","volume":"19","author":"Kariya","year":"1996","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jpba.2019.07.024_bib0160","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jssc.200401830","article-title":"Analysis of flunarizine in the presence of some of its degradation products using micellar liquid chromatography (MLC) or microemulsion liquid chromatography (MELC)-application to dosage forms","volume":"28","author":"El-Sherbiny","year":"2005","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2019.07.024_bib0165","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1212\/WNL.37.5.881","article-title":"Flunarizine- and cinnarizine-induced extrapyramidal reactions","volume":"37","author":"Micheli","year":"1987","journal-title":"Neurology"},{"key":"10.1016\/j.jpba.2019.07.024_bib0170","article-title":"Flunarizine related movement disorders: a nationwide population-based study","author":"Jhang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2019.07.024_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/S0040-4020(01)82187-6","article-title":"Mass spectrometry in structural and stereochemical problems\u2014CXVIII: aliphatic epoxides","author":"Brown","year":"1966","journal-title":"Tetrahydron"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519311586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519311586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:56:55Z","timestamp":1760000215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708519311586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":35,"alternative-id":["S0731708519311586"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.07.024","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simulation of phase I metabolism reactions of selected calcium channel blockers by human liver microsomes and photochemical methods with the use of Q-TOF LC\/MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112776"}}