{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:54:01Z","timestamp":1788303241269,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1061329"],"award-info":[{"award-number":["1061329"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian Government Research Training Program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.jpba.2019.112834","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T11:34:48Z","timestamp":1566560088000},"page":"112834","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Toxicological screening and DNA sequencing detects contamination and adulteration in regulated herbal medicines and supplements for diet, weight loss and cardiovascular health"],"prefix":"10.1016","volume":"176","author":[{"given":"Elly","family":"Crighton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Coghlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Farrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Hoban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.P.","family":"Power","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Mullaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Byard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Trengove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian F.","family":"Musgrave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bunce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth","family":"Maker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jpba.2019.112834_bib0005","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/acm.2006.6355","article-title":"Complementary and alternative medicine use in Australia: a national population-based survey","volume":"13","author":"Xue","year":"2007","journal-title":"J. Altern. Complement. Med."},{"issue":"1","key":"10.1016\/j.jpba.2019.112834_bib0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1592\/phco.20.1.83.34658","article-title":"Assessment of patients\u2019 perceptions and beliefs regarding herbal therapies","volume":"20","author":"Klepser","year":"2000","journal-title":"Pharmacotherapy"},{"issue":"7","key":"10.1016\/j.jpba.2019.112834_bib0015","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/1440-1681.12424","article-title":"A comparison of patterns of spontaneous adverse drug reaction reporting with St. John\u2019s Wort and fluoxetine during the period 2000\u20132013","volume":"42","author":"Hoban","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.jpba.2019.112834_bib0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.eujim.2012.08.003","article-title":"Costs and drivers of complementary and alternative medicine (CAM) use in people with type 2 diabetes or cardiovascular disease","volume":"5","author":"Spinks","year":"2013","journal-title":"Eur. J. Integr. Med."},{"issue":"5","key":"10.1016\/j.jpba.2019.112834_bib0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jamainternmed.2013.2299","article-title":"Why US adults use dietary supplements","volume":"173","author":"Bailey","year":"2013","journal-title":"JAMA Intern. Med."},{"issue":"4","key":"10.1016\/j.jpba.2019.112834_bib0030","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1755-5922.2010.00193.x","article-title":"Safety of herbal supplements: a guide for cardiologists","volume":"28","author":"Cohen","year":"2010","journal-title":"Cardiovasc. Ther."},{"issue":"3","key":"10.1016\/j.jpba.2019.112834_bib0035","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00228-012-1353-z","article-title":"Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews","volume":"69","author":"Posadzki","year":"2013","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2019.112834_bib0040","series-title":"Complementary medicine regulation basics","author":"TGA AGDoHaATGA","year":"2019"},{"key":"10.1016\/j.jpba.2019.112834_bib0045","series-title":"Annual Performance Statistics Report July 2016 to June 2017","author":"TGA AGDoHaATGA","year":"2017"},{"key":"10.1016\/j.jpba.2019.112834_bib0050","series-title":"Australian Government: Department of Health and Ageing D. Expert Review of Medicines and Medical Devices Regulation","year":"2017"},{"key":"10.1016\/j.jpba.2019.112834_bib0055","series-title":"Complementary Medicines Reforms","author":"TGA AGDoHaATGA","year":"2018"},{"key":"10.1016\/j.jpba.2019.112834_bib0060","doi-asserted-by":"crossref","first-page":"17475","DOI":"10.1038\/srep17475","article-title":"Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM)","volume":"5","author":"Coghlan","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jpba.2019.112834_bib0065","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/1741-7015-11-222","article-title":"DNA barcoding detects contamination and substitution in North American herbal products","volume":"11","author":"Newmaster","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jpba.2019.112834_bib0070","series-title":"Australia\u2019s Health Series no. 16. AUS 221","author":"Australian Institute of Health and Welfare","year":"2018"},{"key":"10.1016\/j.jpba.2019.112834_bib0075","series-title":"Dietary Supplements Market Will Reach US$ 179.8 Billion Globally in 2020","author":"Research","year":"2015"},{"issue":"6","key":"10.1016\/j.jpba.2019.112834_bib0080","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/1541-4337.12033","article-title":"Defining the public health threat of dietary supplement fraud","volume":"12","author":"Wheatley","year":"2013","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"6","key":"10.1016\/j.jpba.2019.112834_bib0085","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s40290-018-0252-8","article-title":"Adulterants and contaminants in psychotropic herbal medicines detected with mass spectrometry and next-generation DNA sequencing","volume":"32","author":"Hoban","year":"2018","journal-title":"Pharm. Med."},{"key":"10.1016\/j.jpba.2019.112834_bib0090","doi-asserted-by":"crossref","DOI":"10.5740\/jaoacint.18-0321","article-title":"Recommendations for validation of real-time PCR methods for molecular diagnostic identification of botanicals","author":"Newmaster","year":"2019","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.jpba.2019.112834_bib0095","article-title":"Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment","volume":"2016","author":"Alzohairy","year":"2016","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"5","key":"10.1016\/j.jpba.2019.112834_bib0100","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4103\/0972-5229.120330","article-title":"Neem oil poisoning: case report of an adult with toxic encephalopathy","volume":"17","author":"Mishra","year":"2013","journal-title":"Indian J. Crit. Care Med."},{"key":"10.1016\/j.jpba.2019.112834_bib0105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1155\/2018\/5160254","article-title":"DNA barcoding for the identification and authentication of animal species in traditional medicine","volume":"2018","author":"Yang","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"2","key":"10.1016\/j.jpba.2019.112834_bib0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/pca.2732","article-title":"Benefits and limitations of DNA barcoding and metabarcoding in herbal product authentication","volume":"29","author":"Raclariu","year":"2018","journal-title":"Phytochem. Anal."},{"issue":"1","key":"10.1016\/j.jpba.2019.112834_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0265203021000007840","article-title":"Effects of caffeine on human health","volume":"20","author":"Nawrot","year":"2003","journal-title":"Food Addit. Contam."},{"issue":"3","key":"10.1016\/j.jpba.2019.112834_bib0120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1467-789x.2001.00038.x","article-title":"The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent","volume":"2","author":"Greenway","year":"2001","journal-title":"Obes. Rev."},{"key":"10.1016\/j.jpba.2019.112834_bib0125","series-title":"Substances That May Be Used in Listed Medicines in Australia","author":"TGA AGDoHaATGA","year":"2007"},{"key":"10.1016\/j.jpba.2019.112834_bib0130","series-title":"Herbal Medicines","author":"Barnes","year":"2002"},{"issue":"25","key":"10.1016\/j.jpba.2019.112834_bib0135","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1056\/NEJM200012213432502","article-title":"Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids","volume":"343","author":"Haller","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.jpba.2019.112834_bib0140","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1080\/17512433.2016.1238762","article-title":"Herbal medicines: challenges in the modern world. Part 4. Canada and United States","volume":"9","author":"Job","year":"2016","journal-title":"Expert Rev. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.jpba.2019.112834_bib0145","doi-asserted-by":"crossref","first-page":"S622","DOI":"10.1067\/mai.2000.106153","article-title":"The effects of antihistamines on cognition and performance","volume":"105","author":"Kay","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jpba.2019.112834_bib0150","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1398-9995.2009.02325.x","article-title":"Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper","volume":"65","author":"Church","year":"2010","journal-title":"Allergy"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851931708X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170851931708X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T10:19:29Z","timestamp":1569579569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170851931708X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":30,"alternative-id":["S073170851931708X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112834","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicological screening and DNA sequencing detects contamination and adulteration in regulated herbal medicines and supplements for diet, weight loss and cardiovascular health","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112834","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112834"}}