{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:46:45Z","timestamp":1777873605284,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["UNKP-19-4-SE-28"],"award-info":[{"award-number":["UNKP-19-4-SE-28"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["STIA-18-KF"],"award-info":[{"award-number":["STIA-18-KF"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["STIA-M-17"],"award-info":[{"award-number":["STIA-M-17"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jpba.2019.112851","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T19:24:47Z","timestamp":1567193087000},"page":"112851","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Simultaneous determination of chiral and achiral impurities of ivabradine on a cellulose tris(3-chloro-4-methylphenylcarbamate) chiral column using polar organic mode"],"prefix":"10.1016","volume":"177","author":[{"given":"Elek","family":"Ferencz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisc","family":"Boda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadhassan","family":"Foroughbakhshfasaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va Katalin","family":"Kelemen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerg\u0151","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n-Istv\u00e1n","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2019.112851_bib0005","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(10)61198-1","article-title":"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study","volume":"376","author":"Swedberg","year":"2010","journal-title":"Lancet"},{"issue":"2016","key":"10.1016\/j.jpba.2019.112851_bib0010","volume":"134","author":"Yancy","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jpba.2019.112851_bib0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0014-2999(97)01364-2","article-title":"Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257","volume":"339","author":"Thollon","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpba.2019.112851_bib0020","first-page":"G26","article-title":"Procoralan","volume":"5","author":"Vilaine","year":"2003","journal-title":"a new selective I f current inhibitor"},{"key":"10.1016\/j.jpba.2019.112851_bib0025","unstructured":"chiraltech.com\/wp-content\/uploads\/2017\/04\/Ivabradine-CHIRALPAK-IG.pdf (accessed 08.29.2019)."},{"key":"10.1016\/j.jpba.2019.112851_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00117","article-title":"Forced degradation studies of Ivabradine and in silico toxicology predictions for its new designated impurities","volume":"7","author":"Pikul","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2019.112851_bib0035","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/jms.3533","article-title":"Characterization of degradation products of Ivabradine by LC-HR-MS\/MS: a typical case of exhibition of different degradation behaviour in HCl and H2SO4 acid hydrolysis","volume":"50","author":"Patel","year":"2015","journal-title":"J. Mass Spectrom."},{"issue":"2010","key":"10.1016\/j.jpba.2019.112851_bib0040","first-page":"53","article-title":"Quantitative determination and validation of ivabradine HCl by stability indicating RP-HPLC method and spectrophotometric method in solid dosage form, Eurasian","volume":"5","author":"Maheshwari","year":"2010","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.jpba.2019.112851_bib0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/10826076.2018.1427595","article-title":"Development and validation of UPLC method for simultaneous quantification of carvedilol and ivabradine in the presence of degradation products using DoE concept","volume":"41","author":"Nadella","year":"2018","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.jpba.2019.112851_bib0050","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1021\/cr8005558","article-title":"Structure Control of Polysaccharide Derivatives for Efficient Separation of Enantiomers by Chromatography","volume":"109","author":"Ikai","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jpba.2019.112851_bib0055","series-title":"Polysaccharide-Based Chiral Stationary Phases for Enantioseparations by High-Performance Liquid Chromatography: An Overview","first-page":"93","author":"Chankvetadze","year":"2019"},{"key":"10.1016\/j.jpba.2019.112851_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpba.2012.09.025","article-title":"Enantioselectivity of polysaccharide-based chiral selectors in polar organic solvents chromatography: implementation of chlorinated selectors in a separation strategy","volume":"74","author":"Ates","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112851_bib0065","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/chir.20031","article-title":"Enantiomeric resolution of kielcorin derivatives by HPLC on polysaccharide stationary phases using multimodal elution","volume":"16","author":"Sousa","year":"2004","journal-title":"Chirality"},{"key":"10.1016\/j.jpba.2019.112851_bib0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jpba.2018.06.012","article-title":"Simultaneous determination of dextromepromazine and related substances 2-methoxyphenothiazine and levomepromazine sulfoxide in levomepromazine on a cellulose tris(4-methylbenzoate) chiral column","volume":"158","author":"Niedermeier","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112851_bib0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.chroma.2013.08.029","article-title":"On the effect of basic and acidic additives on the separation of the enantiomers of some basic drugs with polysaccharide-based chiral selectors and polar organic mobile phases","volume":"1317","author":"Mosiashvili","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2019.112851_bib0080","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.chroma.2016.07.022","article-title":"Liquid chromatography separation of the chiral prodrug eslicarbazepine acetate and its main metabolites in polar organic mode. Application to their analysis after in vitro metabolism","volume":"1467","author":"Servais","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2019.112851_bib0085","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jpha.2018.04.001","article-title":"Unusual retention behavior of omeprazole and its chiral impurities B and E on the amylose tris (3-chloro-5-methylphenylcarbamate) chiral stationary phase in polar organic mode","volume":"8","author":"Ferretti","year":"2018","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpba.2019.112851_bib0090","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s10337-018-3546-9","article-title":"Validated LC method for determination of enantiomeric purity of apremilast using polysaccharide-type stationary phases in polar organic mode","volume":"81","author":"Foroughbakhshfasaei","year":"2018","journal-title":"Chromatographia"},{"key":"10.1016\/j.jpba.2019.112851_bib0095","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/jssc.201701211","article-title":"Chiral separation of lenalidomide by liquid chromatography on polysaccharide-type stationary phases and by capillary electrophoresis using cyclodextrin selectors","volume":"41","author":"Szab\u00f3","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2019.112851_bib0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/chir.22772","article-title":"Enantioseparation of racecadotril using polysaccharide-type chiral stationary phases in polar organic mode","volume":"30","author":"Szab\u00f3","year":"2018","journal-title":"Chirality"},{"key":"10.1016\/j.jpba.2019.112851_bib0105","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/elps.201800220","article-title":"Enantiomeric quality control of R -Tofisopam by HPLC using polysaccharide-type chiral stationary phases in polar organic mode","volume":"39","author":"Foroughbakhshfasaei","year":"2018","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jpba.2019.112851_bib0110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00216-012-6302-2","article-title":"Application of quality by design to the development of analytical separation methods","volume":"405","author":"Orlandini","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2019.112851_bib0115","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jpba.2017.05.006","article-title":"An overview of experimental designs in HPLC method development and validation","volume":"147","author":"Sahu","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112851_bib0120","series-title":"International Council for Harmonization Guideline Q2(R1), Validation of Analytical Procedures: Text and Methodology","year":"2005"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519314797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519314797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:05:44Z","timestamp":1777572344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708519314797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":24,"alternative-id":["S0731708519314797"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112851","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous determination of chiral and achiral impurities of ivabradine on a cellulose tris(3-chloro-4-methylphenylcarbamate) chiral column using polar organic mode","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112851","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112851"}}