{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:12:50Z","timestamp":1790039570570,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jpba.2019.112939","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T13:06:33Z","timestamp":1571663193000},"page":"112939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Benchtop NMR spectroscopy in the analysis of substandard and falsified medicines as well as illegal drugs"],"prefix":"10.1016","volume":"178","author":[{"given":"Peter H.J.","family":"Keizers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.K.","family":"Wackers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dion","family":"van Kollenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"van der Aa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"van Beers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2019.112939_bib0005","series-title":"Substandard and Falsified Medical Products","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.jpba.2019.112939_bib0010","series-title":"An \u201caide-m\u00e9moire\u201d for the testing of suspected illegal and counterfeit medicines","author":"General European OMCL Network","year":"2007"},{"key":"10.1016\/j.jpba.2019.112939_bib0015","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jpba.2013.10.038","article-title":"Dose-to-dose variations with single packages of counterfeit medicines and adulterated dietary supplements as a potential source of false negatives and inaccurate health risk assessments","volume":"89","author":"Venhuis","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112939_bib0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jpba.2012.02.014","article-title":"Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks","volume":"69","author":"Venhuis","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112939_bib0025","series-title":"Illicit Erectile Dysfunction Products in the Netherlands: a Decade of Trends and a 2007-2010 Product Update","author":"Venhuis","year":"2011"},{"key":"10.1016\/j.jpba.2019.112939_bib0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.trac.2018.07.015","article-title":"Forensic NMR spectroscopy: just a beginning of a promising partnership","volume":"107","author":"Santos","year":"2018","journal-title":"Trends Anal. Chem."},{"issue":"6","key":"10.1016\/j.jpba.2019.112939_bib0035","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/mrc.4439","article-title":"The emergence of benchtop NMR systems and the exciting future of the technology","volume":"54","author":"Edwards","year":"2016","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jpba.2019.112939_bib0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.aca.2018.12.014","article-title":"Differentiation of fentanyl analogues by low-field NMR spectroscopy","volume":"1049","author":"Duffy","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"24","key":"10.1016\/j.jpba.2019.112939_bib0045","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1002\/anie.201707084","article-title":"Desktop NMR and its applications from materials science to organic chemistry","volume":"57","author":"Blumich","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"9","key":"10.1016\/j.jpba.2019.112939_bib0050","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C7AN00020K","article-title":"Desktop NMR for structure elucidation and identification of strychnine adulteration","volume":"142","author":"Singh","year":"2017","journal-title":"Analyst"},{"issue":"23","key":"10.1016\/j.jpba.2019.112939_bib0055","doi-asserted-by":"crossref","first-page":"11897","DOI":"10.1021\/ac503699u","article-title":"Evaluation of a benchtop cryogen-free low-field (1)H NMR spectrometer for the analysis of sexual enhancement and weight loss dietary supplements adulterated with pharmaceutical substances","volume":"86","author":"Pages","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2019.112939_bib0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.forsciint.2017.08.006","article-title":"Screening of \"spice\" herbal mixtures: from high-field to low-field proton NMR","volume":"279","author":"Assemat","year":"2017","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.jpba.2019.112939_bib0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.forsciint.2017.06.026","article-title":"(1)H and (31)P benchtop NMR of liquids and solids used in and\/or produced during the manufacture of methamphetamine by the HI reduction of pseudoephedrine\/ephedrine","volume":"278","author":"Bogun","year":"2017","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.jpba.2019.112939_bib0070","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.foodchem.2016.08.028","article-title":"Low-field (1)H NMR spectroscopy for distinguishing between arabica and robusta ground roast coffees","volume":"216","author":"Defernez","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2019.112939_bib0075","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jpba.2011.08.036","article-title":"Classification trees based on infrared spectroscopic data to discriminate between genuine and counterfeit medicines","volume":"57","author":"Deconinck","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112939_bib0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.foodchem.2017.10.016","article-title":"High-throughput authentication of edible oils with benchtop Ultrafast 2D NMR","volume":"244","author":"Gouilleux","year":"2018","journal-title":"Food Chem."},{"issue":"12-13","key":"10.1016\/j.jpba.2019.112939_bib0085","first-page":"953","article-title":"Is Low-field NMR a complementary tool to GC-MS in quality control of essential oils? A case study: patchouli essential oil","volume":"84","author":"Krause","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.jpba.2019.112939_bib0090","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.fuel.2018.09.006","article-title":"Using \ufb01eldable spectrometers and chemometric methods to determine RON of gasoline from petrol stations: A comparison of low-\ufb01eld 1H NMR@ 80 MHz, handheld RAMAN and benchtop NIR","volume":"236","author":"Voigt","year":"2019","journal-title":"Fuel"},{"key":"10.1016\/j.jpba.2019.112939_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2014.11.110","article-title":"Authentication of beef versus horse meat using 60 MHz 1H NMR spectroscopy","volume":"175","author":"Jakes","year":"2015","journal-title":"Food Chem."},{"issue":"100","key":"10.1016\/j.jpba.2019.112939_bib0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.trac.2014.02.006","article-title":"60 MHz (1)H NMR spectroscopy for the analysis of edible oils","volume":"57","author":"Parker","year":"2014","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jpba.2019.112939_bib0105","series-title":"General European OMCL Network (GEON)","author":"Council of Europe","year":"2018"},{"issue":"6","key":"10.1016\/j.jpba.2019.112939_bib0110","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1520\/JFS15152J","article-title":"The chemical interconversion of GHB and GBL: forensic issues and implications","volume":"46","author":"Ciolino","year":"2001","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.jpba.2019.112939_bib0115","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpba.2013.09.010","article-title":"Use and qualification of primary and secondary standards employed in quantitative (1)H NMR spectroscopy of pharmaceuticals","volume":"93","author":"Rundlof","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.jpba.2019.112939_bib0120","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/dta.1664","article-title":"A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events","volume":"6","author":"Venhuis","year":"2014","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jpba.2019.112939_bib0125","series-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2008"},{"issue":"5","key":"10.1016\/j.jpba.2019.112939_bib0130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jpba.2010.02.007","article-title":"Survey and qualification of internal standards for quantification by 1H NMR spectroscopy","volume":"52","author":"Rundlof","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112939_bib0135","series-title":"Absorption Spectrophotometry, Ultraviolet and Visible (2.2.25.)","article-title":"European pharmacopoeia","author":"European Pharmacopoeia Commission","year":"2017"},{"key":"10.1016\/j.jpba.2019.112939_bib0140","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jpba.2014.09.008","article-title":"Chemical fingerprinting of silicone-based breast implants","volume":"102","author":"Keizers","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112939_bib0145","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jpba.2018.06.066","article-title":"A high crosslinking grade of hyaluronic acid found in a dermal filler causing adverse effects","volume":"159","author":"Keizers","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112939_bib0150","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.talanta.2018.12.005","article-title":"Benchtop low-field (1)H Nuclear Magnetic Resonance for detecting falsified medicines","volume":"196","author":"Assemat","year":"2019","journal-title":"Talanta"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519317820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519317820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:01:22Z","timestamp":1760000482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708519317820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":30,"alternative-id":["S0731708519317820"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112939","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benchtop NMR spectroscopy in the analysis of substandard and falsified medicines as well as illegal drugs","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112939"}}