{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:52:48Z","timestamp":1765486368581,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jpba.2019.112958","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T09:21:47Z","timestamp":1572686507000},"page":"112958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet"],"prefix":"10.1016","volume":"178","author":[{"given":"Eugenia","family":"Carril","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Pilar","family":"Valdecantos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Lanz\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Angulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela M.","family":"Valverde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Godzien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Rup\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2019.112958_bib0005","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/hep.23594","article-title":"Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection","volume":"51","author":"Starley","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2019.112958_bib0010","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.jpba.2019.112958_bib0015","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1053\/j.gastro.2011.06.061","article-title":"Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States","volume":"141","author":"Charlton","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpba.2019.112958_bib0020","first-page":"218","article-title":"Delayed liver regeneration after partial hepatectomy in aged Nos2 knockout mice","volume":"19","author":"Li","year":"2017","journal-title":"Cell J."},{"key":"10.1016\/j.jpba.2019.112958_bib0025","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/hep.24810","article-title":"Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration","volume":"55","author":"Fern\u00e1ndez-Rojo","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2019.112958_bib0030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3109\/08941939.2014.971206","article-title":"Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery","volume":"28","author":"Hoppe","year":"2015","journal-title":"J. Invest. Surg."},{"key":"10.1016\/j.jpba.2019.112958_bib0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1053\/j.gastro.2017.01.015","article-title":"Metabolomic identification of subtypes of nonalcoholic steatohepatitis","volume":"152","author":"Alonso","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpba.2019.112958_bib0040","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.biochi.2012.11.015","article-title":"A 1H NMR metabolic profiling to the assessment of protein tyrosine phosphatase 1B role in liver regeneration after partial hepatectomy","volume":"95","author":"Samino","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.jpba.2019.112958_bib0045","doi-asserted-by":"crossref","first-page":"16461","DOI":"10.1038\/s41598-018-33949-z","article-title":"Differential effects of a glucagon-like peptide 1 receptor agonist in non-alcoholic fatty liver disease and in response to hepatectomy","volume":"8","author":"Valdecantos","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2019.112958_bib0050","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/hep.28962","article-title":"A novel glucagon-like peptide 1\/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice","volume":"65","author":"Valdecantos","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2019.112958_bib0055","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1021\/ac402411n","article-title":"Multiplatform analytical methodology for metabolic fingerprinting of lung tissue","volume":"85","author":"Naz","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2019.112958_bib0060","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/elps.201700427","article-title":"ROMANCE: A new software tool to improve data robustness and feature identification in CE-MS metabolomics","volume":"39","author":"Gonz\u00e1lez\u2010Ruiz","year":"2018","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jpba.2019.112958_bib0065","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/acs.jproteome.8b00720","article-title":"CEU Mass Mediator 3.0: a metabolite annotation tool","volume":"18","author":"Gil-de-la-Fuente","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2019.112958_bib0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jpba.2018.02.046","article-title":"Knowledge-based metabolite annotation tool: CEU mass mediator","volume":"154","author":"Gil de la Fuente","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2019.112958_bib0075","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","article-title":"Untargeted metabolomics strategies-challenges and emerging directions","volume":"27","author":"Schrimpe-Rutledge","year":"2016","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jpba.2019.112958_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112620","article-title":"The E2F2 transcription factor sustains hepatic glycerophospholipid homeostasis in mice","volume":"9","author":"Maldonado","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2019.112958_bib0085","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1096\/fj.201700866R","article-title":"Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma","volume":"32","author":"Pogribny","year":"2018","journal-title":"Faseb J."},{"key":"10.1016\/j.jpba.2019.112958_bib0090","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1194\/jlr.M600198-JLR200","article-title":"Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1","volume":"47","author":"Rizki","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jpba.2019.112958_bib0095","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.cmet.2011.11.004","article-title":"Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease","volume":"14","author":"Sunny","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jpba.2019.112958_bib0100","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7512159","article-title":"Aberrant metabolism in hepatocellular carcinoma provides diagnostic and therapeutic opportunities","author":"De Matteis","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jpba.2019.112958_bib0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/1751-7915.13324","article-title":"Revisiting the methionine salvage pathway and its paralogues","volume":"12","author":"Sekowska","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.jpba.2019.112958_bib0110","doi-asserted-by":"crossref","first-page":"E308","DOI":"10.3390\/ijms20020308","article-title":"Intestinal microbiota protects against MCD diet-induced steatohepatitis","volume":"20","author":"Schneider","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.jpba.2019.112958_bib0115","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.3748\/wjg.v23.i15.2771","article-title":"Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease","volume":"23","author":"Dong","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jpba.2019.112958_bib0120","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00726-014-1894-9","article-title":"Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease","volume":"47","author":"Lake","year":"2015","journal-title":"Amino Acids"},{"key":"10.1016\/j.jpba.2019.112958_bib0125","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.26226","article-title":"Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease","volume":"58","author":"Begriche","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2019.112958_bib0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jpba.2019.112958_bib0135","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/hep.29359","article-title":"The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids","volume":"67","author":"Daita","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2019.112958_bib0140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/bj2870113","article-title":"Gene expression of regulatory enzymes of glycolysis\/gluconeogenesis in regenerating rat liver","volume":"287","author":"Rosa","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.jpba.2019.112958_bib0145","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.28988","article-title":"Hepatostat: Liver regeneration and normal liver tissue maintenance","volume":"65","author":"Michalopoulos","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jpba.2019.112958_bib0150","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gutjnl-2013-305736","article-title":"The insulin-like growth factor 2 (IGF2) mRNA-binding protein p62\/IGF2BP2-2 as a promoter of NAFLD and HCC?","volume":"63","author":"Simon","year":"2014","journal-title":"Gut"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519319090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519319090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:00:05Z","timestamp":1760000405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708519319090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":30,"alternative-id":["S0731708519319090"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112958","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2019.112958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112958"}}