{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:20:19Z","timestamp":1778998819358,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jpba.2020.113311","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T11:33:16Z","timestamp":1590147196000},"page":"113311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS"],"prefix":"10.1016","volume":"188","author":[{"given":"Elif Tugce","family":"Sarcan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuman","family":"Tas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Silindir-Gunay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuman Yekta","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyda","family":"Colak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baki","family":"Hekimoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2020.113311_bib0005","series-title":"Radiation Injuries. Rosen\u2019s Emergency Medicine: Concepts and Clinical Practise","first-page":"1946","author":"Colwell","year":"2006"},{"key":"10.1016\/j.jpba.2020.113311_bib0010","first-page":"203","article-title":"Radiation Effects on Pharmaceuticals","volume":"35","author":"Abuhanoglu","year":"2010","journal-title":"FABAD J Pharm Sci."},{"key":"10.1016\/j.jpba.2020.113311_bib0015","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3109\/03639045.2014.917093","article-title":"Effect of X-ray Exposure on the Pharmaceutical Quality of Drug Tablets Using X-ray Inspection Equipment","volume":"41","author":"Uehare","year":"2015","journal-title":"Drug Dev Ind Pharm."},{"key":"10.1016\/j.jpba.2020.113311_bib0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.radphyschem.2012.06.038","article-title":"Radiation Processing with High-Energy X-rays","volume":"84","author":"Cleland","year":"2013","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0025","first-page":"46","article-title":"Development of X-ray Inspection System for Pharmaceutical Products","volume":"23","author":"Komiyama","year":"2015","journal-title":"Anritsu Tech Rew."},{"key":"10.1016\/j.jpba.2020.113311_bib0030","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1185\/03007990903299705","article-title":"Effect of X-ray Radiation Exposure on Lyophilized Recombinant Activated Factor VII (Formulated for Storage at Room Temperature)","volume":"25","author":"Vestergaard","year":"2009","journal-title":"Curr Med Res Op."},{"key":"10.1016\/j.jpba.2020.113311_bib0035","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.radphyschem.2003.12.052","article-title":"Radiation Effect Studies on Anti-cancer Drugs, Cyclophosphamide and Doxorubicin for Radiation Sterilization","volume":"71","author":"Varshney","year":"2004","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0040","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0731-7085(96)01947-4","article-title":"The Effect of Gamma Radiation on the Degradation of Salbutamol","volume":"15","author":"Basly","year":"1997","journal-title":"J Pharm Biomed Anal."},{"key":"10.1016\/j.jpba.2020.113311_bib0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ppap.200700096","article-title":"Creation and Recombination of Free Radicals in Fluorocarbon Plasma Polymers: An Electron Spin Resonance Study","volume":"5","author":"Haupt","year":"2008","journal-title":"Plasma Process Polym."},{"key":"10.1016\/j.jpba.2020.113311_bib0050","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/jps.2600831122","article-title":"Estimation of Irradiation Dose of Radiosterilized Antibiotics by ESR: Ampicillin","volume":"83","author":"Miyazaki","year":"1994","journal-title":"J Pharm Sci."},{"key":"10.1016\/j.jpba.2020.113311_bib0055","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0969-8043(96)00210-2","article-title":"ESR Identification of Irradiated Antibiotics: Cephalosporins","volume":"47","author":"Onori","year":"1996","journal-title":"Appl Radiat Isot."},{"key":"10.1016\/j.jpba.2020.113311_bib0060","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/03639049609108354","article-title":"Influence of Radiation Treatment on Pharmaceuticals- A Review: Alkaloids, Morphine Derivatives, and Antibiotics","volume":"22","author":"Boess","year":"1996","journal-title":"Drug Dev Ind Pharm."},{"key":"10.1016\/j.jpba.2020.113311_bib0065","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0969-806X(99)00431-4","article-title":"X-ray Treatment at 5 MeV and Above","volume":"57","author":"Meissner","year":"2000","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0070","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.radphyschem.2007.04.016","article-title":"A high-Performance X-ray System for Medical Device Irradiation","volume":"76","author":"Stichelbaut","year":"2007","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijpharm.2007.07.024","article-title":"J.L. Habib Jiwan, B. Tilquin, Radiosterilization of Drugs in Aqueous Solution may be Achieved by use of Radioprotective Excipients","volume":"349","author":"Maquille","year":"2008","journal-title":"Int J Pharm."},{"key":"10.1016\/j.jpba.2020.113311_bib0080","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.radphyschem.2004.02.006","article-title":"Radiostability of Pharmaceuticals under Different Irradiation Conditions","volume":"72","author":"Crucq","year":"2005","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0085","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.radphyschem.2005.12.020","article-title":"Final Product Analysis in the E-beam and Gamma Radiolysis of Aqueous Solutions of Metoprolol Tartarate","volume":"75","author":"Slegers","year":"2006","journal-title":"Rad Phys Chem."},{"issue":"1079","key":"10.1016\/j.jpba.2020.113311_bib0090","first-page":"1087","article-title":"Study on Gamma and Electron Beam Sterilization of Third Generation Cephalosporins Cefdinir and Cefixime in Solid State","volume":"79","author":"Singh","year":"2010","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0095","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2174\/157341112801264941","article-title":"Comparison of Influence of Gamma Rays and E-beam on Some Chloramphenicol Derivatives","volume":"8","author":"Marciniec","year":"2012","journal-title":"Curr Anal Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0100","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/175720a0","article-title":"Chemical Effects of X-rays Upon Aqueous Solutions of Cortisone and Deoxycorticosterone","volume":"175","author":"Allinson","year":"1955","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2020.113311_bib0105","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0969-806X(01)00565-5","article-title":"Evaluation of Some Selected Vaccines and Other Biological Products Irradiated by Gamma Rays, Electron Beams and X-rays","volume":"63","author":"May","year":"2002","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-806X(02)00410-3","article-title":"Radiological Safety of Food Irradiation with High Energy X-rays: Theoretical Expectations and Experimental Evidence","volume":"67","author":"Gregoire","year":"2003","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0115","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/fstl.1997.0352","article-title":"Comparison of the Effect of X-ray and Electron Beam Irradiation on Some Selected Spices","volume":"31","author":"Van Calenberg","year":"1998","journal-title":"Lebensm Wiss Technol."},{"key":"10.1016\/j.jpba.2020.113311_bib0120","first-page":"846","article-title":"Effect of X-ray, Gamma-Ray, and Electron Beam Irradiation on the Hygienic and Physicochemical Qualities of Red Pepper Powder","volume":"63","author":"Jung","year":"2015","journal-title":"Food Sci Techn."},{"key":"10.1016\/j.jpba.2020.113311_bib0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0969-806X(02)00409-7","article-title":"Radiological Safety of Medical Devices Sterilized with X-rays at 7,5 MeV","volume":"67","author":"Gregoire","year":"2003","journal-title":"Rad Phys Chem."},{"key":"10.1016\/j.jpba.2020.113311_bib0130","doi-asserted-by":"crossref","first-page":"E586","DOI":"10.1208\/pt060473","article-title":"Comparison Between Gamma and Beta Irradiation Effects on Hydroxypropylmethylcellulose and Gelatin Hard Capsules","volume":"6","author":"Cilurzo","year":"2005","journal-title":"AAPS PharmSciTech."},{"key":"10.1016\/j.jpba.2020.113311_bib0135","first-page":"139","article-title":"Effect of Chemical Structure of Vinyl Polymers on Crosslinking and Degradation by Ionizing Radiation","volume":"55","author":"Miller","year":"1954","journal-title":"J Polym Sci."},{"key":"10.1016\/j.jpba.2020.113311_bib0140","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jps.10271","article-title":"Chemical and Physical Stability of Hydroxypropylmethylcellulose Matrices Containing Diltiazem Hydrochlotire after Gamma Irradiation","volume":"92","author":"Maggi","year":"2002","journal-title":"J Pharm Sci."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519331036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708519331036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:03:54Z","timestamp":1760000634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708519331036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":28,"alternative-id":["S0731708519331036"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113311","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113311"}}