{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:40:39Z","timestamp":1760002839984,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jpba.2020.113335","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T12:17:26Z","timestamp":1588162646000},"page":"113335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["A novel LC\u2013MS\/MS analytical method for detection of articaine and mepivacaine in blood and its application to a preliminary pharmacokinetic study"],"prefix":"10.1016","volume":"187","author":[{"given":"Elisabetta","family":"Bertol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Argo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Capretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Ciolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Umani Ronchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Zerbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Mari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Vaiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2020.113335_bib0005","series-title":"Pharmacol. Physiol. Anesth.","first-page":"390","article-title":"Local anesthetics","author":"Suzuki","year":"2019"},{"key":"10.1016\/j.jpba.2020.113335_bib0010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2165\/00003088-197904040-00001","article-title":"Clinical pharmacokinetics of local anaesthetics","volume":"4","author":"Tucker","year":"1979","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jpba.2020.113335_bib0015","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/00000539-200211000-00055","article-title":"The effect of the addition of epinephrine on early systemic absorption of epidural ropivacaine in humans","volume":"95","author":"Lee","year":"2002","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.jpba.2020.113335_bib0020","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2146\/ajhp130336","article-title":"Additives to local anesthetics for peripheral nerve blocks: evidence, limitations, and recommendations","volume":"71","author":"Bailard","year":"2014","journal-title":"Am. J. Health. Syst. Pharm."},{"year":"2017","series-title":"Local Anesthetics","author":"Haas","key":"10.1016\/j.jpba.2020.113335_bib0025"},{"key":"10.1016\/j.jpba.2020.113335_bib0030","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/jat\/11.3.122","article-title":"Comparison of lidocaine by fluorescence polarization immunoassay, enzyme immunoassay, and high resolution gas chromatography","volume":"11","author":"Bertol","year":"1987","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jpba.2020.113335_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003006.pub3","article-title":"Transient neurologic symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics","author":"Zaric","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jpba.2020.113335_bib0040","first-page":"59","article-title":"Review of local anaesthetic agents","volume":"71","author":"Mclure","year":"2005","journal-title":"Minerva Anestesiol."},{"key":"10.1016\/j.jpba.2020.113335_bib0045","first-page":"23","article-title":"Articaine: a review of its use for localand regional anesthesia","volume":"5","author":"Snoeck","year":"2013","journal-title":"Local Reg. Anesth."},{"key":"10.1016\/j.jpba.2020.113335_bib0050","first-page":"191","article-title":"Comparison of carticaine and lidocaine in spinal anaesthesia","volume":"10","author":"Kaukinen","year":"1978","journal-title":"Ann. Clin. Res."},{"key":"10.1016\/j.jpba.2020.113335_bib0055","first-page":"114","article-title":"Articaine and lidocaine for maxillary infiltration anesthesia","volume":"40","author":"V\u00e4h\u00e4talo","year":"1993","journal-title":"Anesth. Prog."},{"key":"10.1016\/j.jpba.2020.113335_bib0060","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jpba.2009.01.028","article-title":"Determination of articaine in human plasma by liquid chromatography-mass spectrometry and its application in a preliminary pharmacokinetic study","volume":"49","author":"Hoizey","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2020.113335_bib0065","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1080\/21691401.2016.1267013","article-title":"A novel LC-MS\/MS method for mepivacaine determination and pharmacokinetic study in a single-dose two-period crossover in healthy subjects","volume":"45","author":"Duan","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.jpba.2020.113335_bib0070","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4103\/0970-9185.142887","article-title":"An atypical case of two instances of mepivacaine toxicity","volume":"30","author":"Manassero","year":"2014","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"10.1016\/j.jpba.2020.113335_bib0075","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/jat\/bkt054","article-title":"Scientific working group for forensic toxicology (SWGTOX) standard practices for method validation in forensic toxicology","volume":"37","author":"SWGTOX","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jpba.2020.113335_bib0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-4347(98)00563-5","article-title":"Solid-phase extraction and high-performance liquid chromatographic determination of articaine and its metabolite articainic acid in human serum","volume":"724","author":"Richter","year":"1999","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520309651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520309651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:02:08Z","timestamp":1760000528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708520309651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":16,"alternative-id":["S0731708520309651"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113335","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel LC\u2013MS\/MS analytical method for detection of articaine and mepivacaine in blood and its application to a preliminary pharmacokinetic study","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113335"}}