{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:15:18Z","timestamp":1789064118699,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jpba.2020.113525","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T18:05:54Z","timestamp":1596391554000},"page":"113525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Application of untargeted lipidomics based on UHPLC-high resolution tandem MS analysis to profile the lipid metabolic disturbances in the heart of diabetic cardiomyopathy mice"],"prefix":"10.1016","volume":"190","author":[{"given":"Xuejun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-2044","authenticated-orcid":false,"given":"Jianping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2020.113525_bib0005","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.ahj.2013.02.024","article-title":"Gender differences in clinical outcomes among diabetic patients hospitalized for cardiovascular disease","volume":"165","author":"Flink","year":"2013","journal-title":"Am. Heart J."},{"key":"10.1016\/j.jpba.2020.113525_bib0010","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.118.314665","article-title":"Diabetic Cardiomyopathy","volume":"124","author":"Dillmann","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.jpba.2020.113525_bib0015","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3389\/fphys.2019.00639","article-title":"Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture","volume":"10","author":"Sowton","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jpba.2020.113525_bib0020","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbalip.2009.09.023","article-title":"Lipotoxicity in the heart","volume":"1801","author":"Wende","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jpba.2020.113525_bib0025","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/0002-9343(54)90365-4","article-title":"Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism","volume":"16","author":"Bing","year":"1954","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jpba.2020.113525_bib0030","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1007\/s00018-011-0690-x","article-title":"Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes","volume":"68","author":"Steinbusch","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jpba.2020.113525_bib0035","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.lfs.2012.10.011","article-title":"Diabetic cardiomyopathy and metabolic remodeling of the heart","volume":"92","author":"Battiprolu","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.jpba.2020.113525_bib0040","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1111\/jcmm.14493","article-title":"4-O-methylhonokiol protects against diabetic cardiomyopathy in type 2 diabetic mice by activation of AMPK-mediated cardiac lipid metabolism improvement","volume":"23","author":"Zheng","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jpba.2020.113525_bib0045","first-page":"75","article-title":"Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation","volume":"15","author":"Chen","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jpba.2020.113525_bib0050","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.tibs.2016.08.010","article-title":"Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences","volume":"41","author":"Yang","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jpba.2020.113525_bib0055","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jpba.2018.09.037","article-title":"Lipid profile perturbations in the plasma and lungs of mice with LPS-induced acute lung injury revealed by UHPLC-ESI-Q Exactive HF MS analysis","volume":"162","author":"Shan","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2020.113525_bib0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nprot.2012.135","article-title":"Global metabolic profiling of animal and human tissues via UPLC-MS","volume":"8","author":"Want","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jpba.2020.113525_bib0065","doi-asserted-by":"crossref","first-page":"E714","DOI":"10.1152\/ajpendo.90413.2008","article-title":"Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus","volume":"295","author":"Hammer","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jpba.2020.113525_bib0070","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1161\/CIRCULATIONAHA.110.955542","article-title":"Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus","volume":"122","author":"Ng","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jpba.2020.113525_bib0075","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/S0140-6736(10)60408-4","article-title":"Lipid-induced insulin resistance: unravelling the mechanism","volume":"375","author":"Samuel","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2020.113525_bib0080","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/jcp.27070","article-title":"Inhibition of JNK and p38 MAPK-mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin-induced diabetic cardiomyopathy","volume":"234","author":"Zuo","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.jpba.2020.113525_bib0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jgg.2017.02.004","article-title":"Metabolomics through the lens of precision cardiovascular medicine","volume":"44","author":"Lam","year":"2017","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.jpba.2020.113525_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008548","article-title":"Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms","volume":"15","author":"Yang","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jpba.2020.113525_bib0095","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2337\/diabetes.53.5.1215","article-title":"Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle","volume":"53","author":"Straczkowski","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.jpba.2020.113525_bib0100","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1210\/er.2007-0025","article-title":"Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism","volume":"29","author":"Holland","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jpba.2020.113525_bib0105","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.tibs.2016.08.010","article-title":"Lipidomics: techniques, applications, and outcomes related to biomedical sciences","volume":"41","author":"Yang","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jpba.2020.113525_bib0110","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13098-017-0249-6","article-title":"Changes of myocardial lipidomics profiling in a rat model of diabetic cardiomyopathy using UPLC\/Q-TOF\/MS analysis","volume":"9","author":"Dong","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.jpba.2020.113525_bib0115","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3389\/fphys.2018.01042","article-title":"Berberine could ameliorate cardiac dysfunction via interfering myocardial lipidomic profiles in the rat model of diabetic cardiomyopathy","volume":"9","author":"Dong","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jpba.2020.113525_bib0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2020.113525_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114969","article-title":"Betaine and Trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study","volume":"9","author":"Lever","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2020.113525_bib0130","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.cell.2015.11.055","article-title":"Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis","volume":"163","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jpba.2020.113525_bib0135","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jpba.2020.113525_bib0140","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/sj.ijo.0801498","article-title":"Lipotoxic diseases of nonadipose tissues in obesity","volume":"24","author":"Unger","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.jpba.2020.113525_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.032086","article-title":"Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity","volume":"11","author":"Mar\u00edn-Royo","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.jpba.2020.113525_bib0150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.freeradbiomed.2018.10.445","article-title":"GCN2 Deficiency Ameliorates Cardiac Dysfunction in Diabetic Mice by Reducing Lipotoxicity and Oxidative Stress","volume":"130","author":"Feng","year":"2019","journal-title":"Free Radic. Biol. Med."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520314114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520314114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:07:48Z","timestamp":1760000868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708520314114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":30,"alternative-id":["S0731708520314114"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113525","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of untargeted lipidomics based on UHPLC-high resolution tandem MS analysis to profile the lipid metabolic disturbances in the heart of diabetic cardiomyopathy mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113525","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113525"}}