{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:07:33Z","timestamp":1781680053009,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jpba.2020.113638","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T12:48:42Z","timestamp":1600346922000},"page":"113638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Simultaneous determination of twelve quinones from Rubiae radix et Rhizoma before and after carbonization processing by UPLC-MS\/MS and their antithrombotic effect on zebrafish"],"prefix":"10.1016","volume":"191","author":[{"given":"Authors: Kan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-qiu","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-wei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.jpba.2020.113638_bib0005","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1016\/j.jacc.2017.04.041","article-title":"Traditional Chinese Medicine for Cardiovascular Disease: Evidence and Potential Mechanisms","volume":"69","author":"Hao","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.jpba.2020.113638_bib0010","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/13880209.2019.1645700","article-title":"A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect","volume":"57","author":"Chen","year":"2019","journal-title":"Pharm Biol"},{"issue":"5","key":"10.1016\/j.jpba.2020.113638_bib0015","first-page":"663","article-title":"Induction of apoptosis underlies the Radix Rubiae-mediated anti-proliferative action on human epidermal keratinocytes: implications for psoriasis treatment","volume":"20","author":"Tse","year":"2007","journal-title":"Int. J. Mol. Med."},{"issue":"12","key":"10.1016\/j.jpba.2020.113638_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21121747","article-title":"A review of the botany, phytochemistry, pharmacology and toxicology of rubiae Radix et rhizoma","volume":"21","author":"Shan","year":"2016","journal-title":"Molecules"},{"issue":"03","key":"10.1016\/j.jpba.2020.113638_bib0025","first-page":"493","article-title":"Comparative study on effects of Rubiae Radix et Rhizoma and carbonized Rubiae Radix et Rhizoma on acute blood stasis rat model","author":"Shan","year":"2014","journal-title":"China J. Chinese Matera Med."},{"issue":"1","key":"10.1016\/j.jpba.2020.113638_bib0030","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/molecules14010566","article-title":"Rubiacordone A: a new anthraquinone glycoside from the roots of Rubia cordifolia","volume":"14","author":"Li","year":"2009","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.jpba.2020.113638_bib0035","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2298\/JSC0507937S","article-title":"Isolation and synthesis of anthraquinones and related compounds of Rubia cordifolia","volume":"70","author":"Singh","year":"2005","journal-title":"J Serb Chem Soc"},{"issue":"3","key":"10.1016\/j.jpba.2020.113638_bib0040","first-page":"216","article-title":"Two new anthraquinones from the roots of Rubia cordifolia Linn","volume":"58","author":"Abdullah","year":"2003","journal-title":"Pharmazie"},{"issue":"10","key":"10.1016\/j.jpba.2020.113638_bib0045","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/ptr.1752","article-title":"Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents","volume":"19","author":"Basu","year":"2005","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.jpba.2020.113638_bib0050","first-page":"330","article-title":"Inhibition of hepatitis B surface antigen secretion on human hepatoma cells","volume":"59","author":"Ho","year":"1996","journal-title":"Components from Rubia cordifolia, J Nat Prod"},{"issue":"26","key":"10.1016\/j.jpba.2020.113638_bib0055","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1021\/jf0489116","article-title":"Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships","volume":"52","author":"Cai","year":"2004","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.jpba.2020.113638_bib0060","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1089\/jmf.2010.1385","article-title":"Anti-adipogenic activity of 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone from Rubia cordifolia L","volume":"14","author":"Jun","year":"2011","journal-title":"J. Med. Food"},{"issue":"04","key":"10.1016\/j.jpba.2020.113638_bib0065","article-title":"Determination of three active ingredients in Radix rubiae by quantitative analysis of multi-components with single-marker","volume":"32","author":"Wang","year":"2016","journal-title":"J. Harbin Univ. Commerce (Natural Sciences Edition)"},{"issue":"03","key":"10.1016\/j.jpba.2020.113638_bib0070","first-page":"195","article-title":"Simultaneous determination of alizarin, purpurin and mollugin in Rubia cordifolia L. By HPLC","volume":"51","author":"Yu","year":"2017","journal-title":"J. Harbin Medical Univ."},{"issue":"12","key":"10.1016\/j.jpba.2020.113638_bib0075","first-page":"9","article-title":"Determination of 1,3,6-trihydroxy-2-methylanthraquinone in Rubiae Radix et Rhizoma before and after prepared by UPLC","volume":"14","author":"Shan","year":"2012","journal-title":"Modern Chin. Med."},{"issue":"23","key":"10.1016\/j.jpba.2020.113638_bib0080","first-page":"4604","article-title":"Protective effect of different polar fractions of Carbonized Rubiae Radix et Rhizoma (cRRR) against oxidative injury","volume":"42","author":"Xiao","year":"2017","journal-title":"China J. Chin. Matera Med."},{"key":"10.1016\/j.jpba.2020.113638_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122040","article-title":"A rapid method for simultaneous quantification of berberine, berbamine, magnoflorine and berberrubine in mouse serum using UPLC-MS\/MS","volume":"1142","author":"Liang","year":"2020","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2020.113638_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.112938","article-title":"Pharmacokinetic and metabolic profiling studies of sennoside B by UPLC-MS\/MS and UPLC-Q-TOF-MS","volume":"179","author":"Wu","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.jpba.2020.113638_bib0095","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/14740338.2017.1315101","article-title":"The risk of bleeding with the use of antiplatelet agents for the treatment of cardiovascular disease","volume":"16","author":"Nathan","year":"2017","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.jpba.2020.113638_bib0100","first-page":"1803","article-title":"Study on hemostatic components of Rubiae radix et rhizome carbonisatum","volume":"12","author":"Zhang","year":"2007","journal-title":"Chin. Traditional Patent Med."},{"issue":"9","key":"10.1016\/j.jpba.2020.113638_bib0105","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/CIRCRESAHA.115.306823","article-title":"Animal models of thrombosis from zebrafish to nonhuman Primates: use in the elucidation of new pathologic pathways and the development of antithrombotic drugs","volume":"118","author":"Jagadeeswaran","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.jpba.2020.113638_bib0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1538-7836.2004.00999.x","article-title":"Zebrafish: a genetic model for hemostasis and thrombosis","volume":"3","author":"Jagadeeswaran","year":"2005","journal-title":"J. Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.jpba.2020.113638_bib0115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1089\/zeb.2016.1263","article-title":"A zebrafish thrombosis model for assessing antithrombotic drugs","volume":"13","author":"Zhu","year":"2016","journal-title":"Zebrafish"},{"issue":"4","key":"10.1016\/j.jpba.2020.113638_bib0120","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1039\/C7TX00005G","article-title":"A developmental toxicity assay of Carpesii Fructus on zebrafish embryos\/larvae","volume":"6","author":"Xia","year":"2017","journal-title":"Toxicol. Res. (Camb)"},{"key":"10.1016\/j.jpba.2020.113638_bib0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2018.04.037","article-title":"Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA\/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish","volume":"350","author":"Zhou","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jpba.2020.113638_bib0130","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jpba.2018.03.035","article-title":"Simultaneous quantification of twelve compounds in ethyl acetate extracts of Euphorbia kansui before and after fry-baked with vinegar by UPLC-MS\/MS and its toxic effect on zebrafish","volume":"155","author":"Zhang","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2020.113638_bib0135","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jep.2017.11.005","article-title":"Anti-thrombotic and pro-angiogenic effects of Rubia cordifolia extract in zebrafish","volume":"219","author":"Chen","year":"2018","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520315247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520315247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:11:30Z","timestamp":1760001090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708520315247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":27,"alternative-id":["S0731708520315247"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113638","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous determination of twelve quinones from Rubiae radix et Rhizoma before and after carbonization processing by UPLC-MS\/MS and their antithrombotic effect on zebrafish","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113638"}}