{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:43:43Z","timestamp":1792881823436,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000149","name":"Canadian Association of Gastroenterology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000149","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McMaster Children\u2019s Hospital Centre for Child & Youth Digestive Diseases Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jpba.2020.113658","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T10:58:00Z","timestamp":1601722680000},"page":"113658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Lyophilized fecal short-chain fatty acid and electrolyte determination by capillary electrophoresis with indirect UV detection for assessment of pediatric inflammatory bowel disease"],"prefix":"10.1016","volume":"192","author":[{"given":"Julie-Anne","family":"Lemay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Kroezen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Shanmuganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchie","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Britz-McKibbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"68","key":"10.1016\/j.jpba.2020.113658_bib0005","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1136\/gutjnl-2019-318484","article-title":"British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults","volume":"68","author":"Lamb","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jpba.2020.113658_bib0010","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/jamapediatrics.2015.1982","article-title":"Inflammatory bowel disease in children and adolescents","volume":"169","author":"Rosen","year":"2015","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.jpba.2020.113658_bib0015","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/gut.2009.188383","article-title":"Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data","volume":"58","author":"Benchimol","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.jpba.2020.113658_bib0020","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2020.113658_bib0025","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/ibd.21493","article-title":"Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification","volume":"17","author":"Levine","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jpba.2020.113658_bib0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clnu.2018.01.020","article-title":"Exclusive enteral nutrition in Crohn\u2019s disease: evidence and practicalities","volume":"38","author":"Ashton","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.jpba.2020.113658_bib0035","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12519-018-0204-0","article-title":"Exclusive enteral nutrition versus corticosteroids for treatment of pediatric Crohn\u2019s disease: a meta-analysis","volume":"15","author":"Yu","year":"2019","journal-title":"World J. Pediatr."},{"key":"10.1016\/j.jpba.2020.113658_bib0040","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3390\/nu12061691","article-title":"Effect of exclusive enteral nutrition and corticosteroid induction therapy on the gut microbiota of pediatric patients with inflammatory bowel disease","volume":"12","author":"Hart","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2020.113658_bib0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"11","author":"Parada Venegas","year":"2019","journal-title":"Frontiers Immunol."},{"key":"10.1016\/j.jpba.2020.113658_bib0050","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/ibd\/izz188","article-title":"Systematic review and meta-analysis: short-chain fatty acid characterization in patients with inflammatory bowel disease","volume":"25","author":"Zhuang","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jpba.2020.113658_bib0055","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1021\/acs.analchem.5b04159","article-title":"Optimized sample handling strategy for metabolomic profiling of human feces","volume":"88","author":"Gratton","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2020.113658_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ab.2017.03.007","article-title":"Analysis of short-chain fatty acids in human feces: a scoping review","volume":"526","author":"Primec","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jpba.2020.113658_bib0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ab.2017.12.001","article-title":"Rapid profiling method for mammalian feces short chain fatty acids by GC-MS","volume":"543","author":"Furuhashi","year":"2018","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jpba.2020.113658_bib0070","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/acs.jproteome.8b00536","article-title":"Evaluation and optimization of sample handling methods for quantification of short-chain fatty acids in human fecal samples by GC\u2013MS","volume":"18","author":"Hsu","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2020.113658_bib0075","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.aca.2014.11.015","article-title":"An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography-tandem mass spectrometry","volume":"854","author":"Han","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2020.113658_bib0080","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/biom9040121","article-title":"Quantification of fecal short chain fatty acids by liquid chromatography tandem mass spectrometry\u2014investigation of pre-analytic stability","volume":"9","author":"Liebisch","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jpba.2020.113658_bib0085","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jpba.2017.04.006","article-title":"Validation and application of an ultrahigh-performance liquid chromatographic-Orbitrap mass spectrometric method for the simultaneous detection and quantification of volatile and non-volatile organic acids in human faecal samples","volume":"141","author":"Gardana","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2020.113658_bib0090","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1039\/C9AY01202H","article-title":"Determination of short-chain fatty acids in feces by capillary electrophoresis with indirect UV-VIS detection","volume":"11","author":"Hodek","year":"2019","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jpba.2020.113658_bib0095","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jpba.2007.10.026","article-title":"Capillary electrophoresis for short chain organic acids in faeces Reference values in a Mediterranean elderly population","volume":"46","author":"Garcia","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2020.113658_bib0100","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1021\/acs.analchem.9b00149","article-title":"Characterization of the human skeletal muscle metabolome for elucidating the mechanisms of bicarbonate ingestion on strenuous interval exercise","volume":"9","author":"Saoi","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2020.113658_bib0105","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1097\/MIB.0000000000000504","article-title":"Mechanisms underlying dysregulation of electrolyte absorption in IBD associated diarrhea","volume":"21","author":"Priyamvada","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"10.1016\/j.jpba.2020.113658_bib0110","doi-asserted-by":"crossref","first-page":"16585","DOI":"10.1021\/acsomega.8b01761","article-title":"Impact of sample storage on the NMR fecal water metabolome","volume":"3","author":"O\u2019Sullivan","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.jpba.2020.113658_bib0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1099\/00222615-13-1-45","article-title":"The microbial contribution to human faecal mass","volume":"13","author":"Stephen","year":"1980","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jpba.2020.113658_bib0120","doi-asserted-by":"crossref","first-page":"11112","DOI":"10.1021\/ac402975q","article-title":"Strong anion determination in biological fluids by capillary electrophoresis for clinical diagnostics","volume":"85","author":"Nori de Macedo","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2020.113658_bib0125","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.3748\/wjg.v25.i36.5543","article-title":"Evaluation and comparison of short chain fatty acids composition in gut diseases","volume":"25","author":"Niccolai","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jpba.2020.113658_bib0130","first-page":"159","article-title":"Fecal short-chain fatty acids in children with inflammatory bowel disease","volume":"18","author":"Treem","year":"1994","journal-title":"Gastroenterol. Nutr."},{"key":"10.1016\/j.jpba.2020.113658_bib0135","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/1874091X01004010053","article-title":"The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects","volume":"4","author":"Huda-Faujan","year":"2010","journal-title":"Open Biochem. J."},{"key":"10.1016\/j.jpba.2020.113658_bib0140","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/gut.46.6.819","article-title":"Absorption of calcium and magnesium in patients with intestinal resections treated with medium chain fatty acids","volume":"46","author":"Haderslev","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.jpba.2020.113658_bib0145","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1172\/JCI200318326","article-title":"Intestinal ion transport and the pathophysiology of diarrhea","volume":"111","author":"Field","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jpba.2020.113658_bib0150","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4239\/wjd.v5.i4.527","article-title":"Domino effect of hypomagnesemia on the innate immunity of Crohn\u2019s disease patients","volume":"5","author":"Naser","year":"2014","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.jpba.2020.113658_bib0155","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1462-2920.2009.02066.x","article-title":"Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene","volume":"12","author":"Louis","year":"2010","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.jpba.2020.113658_bib0160","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","article-title":"A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis","volume":"63","author":"Machiels","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jpba.2020.113658_bib0165","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1097\/MIB.0000000000000836","article-title":"Emerging biomarkers for the diagnosis and monitoring of inflammatory bowel diseases","volume":"22","author":"Soubi\u00e8res","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jpba.2020.113658_bib0170","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.clnu.2016.12.027","article-title":"ESPEN guideline: clinical nutrition in inflammatory bowel disease","volume":"36","author":"Forbes","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.jpba.2020.113658_bib0175","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016698","article-title":"Protocol for a randomised, placebo-controlled pilot study for assessing feasibility and efficacy of faecal microbiota transplantation in a paediatric ulcerative colitis population: PediFETCh trial","volume":"7","author":"Pai","year":"2017","journal-title":"BMJ Open"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520315442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520315442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:07:32Z","timestamp":1760000852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708520315442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":35,"alternative-id":["S0731708520315442"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113658","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lyophilized fecal short-chain fatty acid and electrolyte determination by capillary electrophoresis with indirect UV detection for assessment of pediatric inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113658","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113658"}}